PMID- 33998406
OWN - NLM
STAT- MEDLINE
DCOM- 20210518
LR  - 20220531
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 61
IP  - 4
DP  - 2021 May 4
TI  - Blood Adipokins in Young People with Early Ischemic Heart Disease on the 
      Background of Abdominal Obesity.
PG  - 32-38
LID - 10.18087/cardio.2021.4.n1369 [doi]
AB  - Aim      To study blood adipokines spectrum in people aged 25-44 years with early 
      ischemic heart disease (IHD), including that associated with abdominal obesity 
      (AO).Material and methods  A cross-sectional study was performed on a random 
      sample of the population aged 25-44 years in Novosibirsk. 1457 subjects (653 men, 
      804 women) were evaluated. This study included 123 people divided into four study 
      subgroups: subgroup 1, with IHD associated with AO (n=24); subgroup 2, with IHD 
      and without AO (n=25); subgroup 3, without IHD and with AO (n=44); and subgroup 
      4, without either IHD or AO (n=30). Concentrations of serum adipokines were 
      measured simultaneously by multiplex assay with a Luminex MAGPIX flow fluorometer 
      and by immune enzyme assay with a MULTISCAN analyzer.Results Subjects with early 
      IHD had lower blood concentrations of adipsin and visfatin than subjects without 
      IHD. Subjects with early IHD associated with AO had higher blood concentrations 
      of adipsin, plasminogen activator inhibitor-1, and leptin and lower 
      concentrations of monocyte chemoattractant protein-1 (MCP-1) and visfatin 
      compared to subjects with early IHD and without AO. The multivariate logistic 
      regression analysis showed that lower blood concentrations of MCP-1 were 
      associated with a likelihood of early IHD.Conclusion      In young people aged 
      25-44 years, lower blood concentrations of MCP-1 were associated with a 
      likelihood of early IHD, including that associated with AO.
FAU - Ragino, Yu I
AU  - Ragino YI
AD  - The Institute of Internal and Preventive Medicine - a branch of a federal 
      publicly funded scientific institution, the federal research center Institute of 
      Cytology and Genetics, Novosibirsk.
FAU - Shcherbakova, L V
AU  - Shcherbakova LV
AD  - The Institute of Internal and Preventive Medicine - a branch of a federal 
      publicly funded scientific institution, the federal research center Institute of 
      Cytology and Genetics, Novosibirsk.
FAU - Oblaukhova, V I
AU  - Oblaukhova VI
AD  - The Institute of Internal and Preventive Medicine - a branch of a federal 
      publicly funded scientific institution, the federal research center Institute of 
      Cytology and Genetics, Novosibirsk.
FAU - Polonskaya, Ya V
AU  - Polonskaya YV
AD  - The Institute of Internal and Preventive Medicine - a branch of a federal 
      publicly funded scientific institution, the federal research center Institute of 
      Cytology and Genetics, Novosibirsk.
FAU - Stakhneva, E M
AU  - Stakhneva EM
AD  - The Institute of Internal and Preventive Medicine - a branch of a federal 
      publicly funded scientific institution, the federal research center Institute of 
      Cytology and Genetics, Novosibirsk.
FAU - Kuzminykh, N A
AU  - Kuzminykh NA
AD  - The Institute of Internal and Preventive Medicine - a branch of a federal 
      publicly funded scientific institution, the federal research center Institute of 
      Cytology and Genetics, Novosibirsk.
FAU - Kashtanova, E V
AU  - Kashtanova EV
AD  - The Institute of Internal and Preventive Medicine - a branch of a federal 
      publicly funded scientific institution, the federal research center Institute of 
      Cytology and Genetics, Novosibirsk.
LA  - rus
LA  - eng
PT  - Journal Article
DEP - 20210504
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
RN  - 0 (Adipokines)
SB  - IM
MH  - Adipokines
MH  - Adolescent
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Myocardial Ischemia/complications/epidemiology
MH  - *Obesity, Abdominal/complications/epidemiology
MH  - Risk Factors
EDAT- 2021/05/18 06:00
MHDA- 2021/05/19 06:00
CRDT- 2021/05/17 08:48
PHST- 2020/09/18 00:00 [received]
PHST- 2020/11/24 00:00 [accepted]
PHST- 2020/11/06 00:00 [revised]
PHST- 2021/05/17 08:48 [entrez]
PHST- 2021/05/18 06:00 [pubmed]
PHST- 2021/05/19 06:00 [medline]
AID - 10.18087/cardio.2021.4.n1369 [doi]
PST - epublish
SO  - Kardiologiia. 2021 May 4;61(4):32-38. doi: 10.18087/cardio.2021.4.n1369.