PMID- 33998938 OWN - NLM STAT- MEDLINE DCOM- 20220308 LR - 20220308 IS - 1473-7760 (Electronic) IS - 1052-0295 (Linking) VI - 97 IP - 3 DP - 2022 Apr TI - Partial protective effects of melatonin on cadmium-induced changes in hematological characteristics in rats. PG - 192-198 LID - 10.1080/10520295.2021.1925965 [doi] AB - We investigated the effects of melatonin (Mlt) on hematological characteristics to determine the percentage of alpha-naphthyl acetate esterase (ANAE) positive lymphocytes in rats chronically exposed to cadmium (Cd). We used four groups of male rats: control (C), melatonin (Mlt), cadmium (Cd) and Cd + Mlt (CdMlt). Blood samples were obtained to assess the erythrocytes (RBC), leukocytes (WBC), platelets (PLT), hemoglobin (HGB), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV) as well as alpha-naphthyl acetate esterase (ANAE) positive lymphocytes. We found that the number of WBC increased in the Cd group compared to the other three experimental groups. Low MCV and MCHC values caused by Cd were ameliorated by Mlt treatment in the CdMlt group. We found no significant change in the RBC, HGB, MCH, PLT and HCT values among the experimental groups. Mlt treatment also increased the percentage of ANAE positive lymphocytes. Mlt partially protects some hematological characteristics in cases of chronic Cd toxicity. FAU - Kisadere, Ihsan AU - Kisadere I AUID- ORCID: 0000-0003-0732-0464 AD - Department of Physiology, Faculty of Veterinary, University of Balikesir, Balikesir, Turkey. FAU - Aydin, Mehmet Faruk AU - Aydin MF AD - Department of Histology and Embryology, Faculty of Veterinary, University of Balikesir, Balikesir, Turkey. FAU - Undag, Ilknur AU - Undag I AUID- ORCID: 0000-0001-8495-3930 AD - Department of Histology and Embryology, Faculty of Veterinary, University of Selcuk, Konya, Turkey. LA - eng PT - Journal Article DEP - 20210517 PL - England TA - Biotech Histochem JT - Biotechnic & histochemistry : official publication of the Biological Stain Commission JID - 9107378 RN - 00BH33GNGH (Cadmium) RN - JL5DK93RCL (Melatonin) SB - IM MH - Animals MH - *Cadmium/toxicity MH - Erythrocyte Indices MH - Erythrocytes MH - Hematocrit MH - Male MH - *Melatonin/pharmacology MH - Rats OTO - NOTNLM OT - Alpha-naphthyl acetate esterase OT - cadmium OT - hematology OT - melatonin OT - rats OT - toxicity EDAT- 2021/05/18 06:00 MHDA- 2022/03/09 06:00 CRDT- 2021/05/17 12:20 PHST- 2021/05/18 06:00 [pubmed] PHST- 2022/03/09 06:00 [medline] PHST- 2021/05/17 12:20 [entrez] AID - 10.1080/10520295.2021.1925965 [doi] PST - ppublish SO - Biotech Histochem. 2022 Apr;97(3):192-198. doi: 10.1080/10520295.2021.1925965. Epub 2021 May 17.