PMID- 34001394
OWN - NLM
STAT- MEDLINE
DCOM- 20220104
LR  - 20220104
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 48
IP  - 6
DP  - 2021 Dec
TI  - Clinicopathological significance of SOX4 and epithelial-mesenchymal transition 
      markers in patients with laryngeal squamous cell carcinoma.
PG  - 1167-1175
LID - S0385-8146(21)00136-X [pii]
LID - 10.1016/j.anl.2021.04.013 [doi]
AB  - OBJECTIVE: Sex-determining region-Y-related high-mobility-group box 4 (SOX4) is 
      associated with the metastasis and prognosis of many cancer types. However, 
      studies on the role of SOX4 in laryngeal squamous cell carcinoma (LSCC) are few, 
      and hence the mechanism is unclear. Epithelial-mesenchymal transition (EMT) 
      allows neoplastic cells to gain the plasticity and motility required for tumor 
      progression and metastasis. This study aimed to analyze the relationship between 
      SOX4 and EMT, and their relationship with clinicopathological factors and related 
      prognosis. METHODS: Immunohistochemical staining was used to detect the positive 
      expression of SOX4 protein, EMT-related transcription factor protein, and related 
      marker protein in 127 LSCC tissue samples. At the same time, data on various 
      parameters of clinical pathology and postoperative survival were collected. 
      RESULTS: The positive expression rate of SOX4 and Slug in LSCC was related to 
      pathological differentiation, Lymph node metastasis (LNM), and pathological TNM 
      of a tumor. The expression rates of ZEB1, E-cadherin, N-cadherin, and beta-catenin 
      in LSCC correlated with LNM and pTNM. The expression of SOX4, combined expression 
      of SOX4 and ZEB1, and LNM were independent prognostic factors for the total 
      survival time of patients with LSCC. CONCLUSIONS: In summary, SOX4 was vital in 
      the LSCC EMT process, which might be mediated by transcription factor ZEB1. SOX4 
      and ZEB1 might serve as potential biomarkers of metastasis and prognosis, as well 
      as promising therapeutic targets of LSCC.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Zhang, Mingjie
AU  - Zhang M
AD  - Department of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, 
      Guangdong 510632, China; Department of Otolaryngology Head and Neck Surgery, The 
      First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui 233000, China.
FAU - Han, Yuefeng
AU  - Han Y
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui 233000, China.
FAU - Wang, Mengjun
AU  - Wang M
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui 233000, China.
FAU - Zhang, Junjie
AU  - Zhang J
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui 233000, China.
FAU - Ma, Shiyin
AU  - Ma S
AD  - Department of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, 
      Guangdong 510632, China; Department of Otolaryngology Head and Neck Surgery, The 
      First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China. 
      Electronic address: msy@bbmc.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210514
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cadherins)
RN  - 0 (SNAI1 protein, human)
RN  - 0 (SOX4 protein, human)
RN  - 0 (SOXC Transcription Factors)
RN  - 0 (Snail Family Transcription Factors)
RN  - 0 (ZEB1 protein, human)
RN  - 0 (Zinc Finger E-box-Binding Homeobox 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Biomarkers, Tumor/*metabolism
MH  - Cadherins/metabolism
MH  - Epithelial-Mesenchymal Transition/*physiology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - SOXC Transcription Factors/*metabolism
MH  - Snail Family Transcription Factors/metabolism
MH  - Squamous Cell Carcinoma of Head and Neck/*metabolism/mortality/pathology
MH  - Zinc Finger E-box-Binding Homeobox 1/*metabolism
OTO - NOTNLM
OT  - EMT
OT  - Laryngeal squamous cell carcinoma
OT  - SOX4
OT  - ZEB1
COIS- Declaration of Competing Interest The authors have no conflict of interest 
      relevant to the content of this article.
EDAT- 2021/05/19 06:00
MHDA- 2022/01/05 06:00
CRDT- 2021/05/18 06:23
PHST- 2021/02/24 00:00 [received]
PHST- 2021/04/18 00:00 [revised]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2021/05/19 06:00 [pubmed]
PHST- 2022/01/05 06:00 [medline]
PHST- 2021/05/18 06:23 [entrez]
AID - S0385-8146(21)00136-X [pii]
AID - 10.1016/j.anl.2021.04.013 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2021 Dec;48(6):1167-1175. doi: 10.1016/j.anl.2021.04.013. 
      Epub 2021 May 14.