PMID- 34001436
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220310
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Linking)
VI  - 121
DP  - 2022 Jan
TI  - Stem Leydig cells: Current research and future prospects of regenerative medicine 
      of male reproductive health.
PG  - 63-70
LID - S1084-9521(21)00116-6 [pii]
LID - 10.1016/j.semcdb.2021.05.007 [doi]
AB  - Stem cells are specialized cells that can renew themselves through cell division 
      and can differentiate into multi-lineage cells. Mesenchymal stem cells are adult 
      stem cells that exist in animal and human tissues. Mesenchymal stem cells have 
      the ability to differentiate into mesodermal lineages, such as Leydig cells, 
      adipocytes, osteocytes, and chondrocytes. Mesenchymal stem cells express cell 
      surface markers, such as cluster of differentiation (CD) 29, CD44, CD73, CD90, 
      CD105, and lack the expression of CD14, CD34, CD45 and HLA (human leukocyte 
      antigen)-DR. Stem Leydig cells are one kind of mesenchymal stem cells, which are 
      present in the interstitial compartment of testis. Stem Leydig cells are 
      multipotent and can differentiate into Leydig cells, adipocytes, osteocytes, and 
      chondrocytes. Stem Leydig cells have been isolated from rodent and human testes. 
      Stem Leydig cells may have potential therapeutic values in several clinical 
      applications, such as the treatment of male hypogonadism and infertility. In this 
      review, we focus on the latest research on stem Leydig cells of both rodents and 
      human, the expression of cell surface markers, culture, differentiation 
      potential, and their applications.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Li, Xiaoheng
AU  - Li X
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital and 
      Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, 
      Wenzhou, Zhejiang 325027, China.
FAU - Tian, Erpo
AU  - Tian E
AD  - Xi'nan Gynecological Hospital, Chengdu, Sichuan, China.
FAU - Wang, Yiyan
AU  - Wang Y
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital and 
      Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, 
      Wenzhou, Zhejiang 325027, China.
FAU - Wen, Zina
AU  - Wen Z
AD  - Xi'nan Gynecological Hospital, Chengdu, Sichuan, China.
FAU - Lei, Zhen
AU  - Lei Z
AD  - Xi'nan Gynecological Hospital, Chengdu, Sichuan, China.
FAU - Zhong, Ying
AU  - Zhong Y
AD  - Xi'nan Gynecological Hospital, Chengdu, Sichuan, China. Electronic address: 
      yzhong8@yahoo.com.
FAU - Ge, Ren-Shan
AU  - Ge RS
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital and 
      Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, 
      Wenzhou, Zhejiang 325027, China; Xi'nan Gynecological Hospital, Chengdu, Sichuan, 
      China. Electronic address: renshan_ge@wmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210515
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
SB  - IM
MH  - Animals
MH  - Humans
MH  - Leydig Cells/*metabolism
MH  - Male
MH  - Mice
MH  - Rats
MH  - Regenerative Medicine/*methods
MH  - Reproductive Health/*standards
OTO - NOTNLM
OT  - Hypogonadism
OT  - Male infertility
OT  - Mesenchymal stem cells
OT  - Regenerative medicine
OT  - Stem Leydig cells
EDAT- 2021/05/19 06:00
MHDA- 2022/03/11 06:00
CRDT- 2021/05/18 06:24
PHST- 2021/02/15 00:00 [received]
PHST- 2021/05/03 00:00 [revised]
PHST- 2021/05/05 00:00 [accepted]
PHST- 2021/05/19 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2021/05/18 06:24 [entrez]
AID - S1084-9521(21)00116-6 [pii]
AID - 10.1016/j.semcdb.2021.05.007 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2022 Jan;121:63-70. doi: 10.1016/j.semcdb.2021.05.007. Epub 
      2021 May 15.