PMID- 34002561
OWN - NLM
STAT- MEDLINE
DCOM- 20210519
LR  - 20210519
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 41
IP  - 5
DP  - 2021 May 12
TI  - [Effect of fire needling on mild to moderate knee osteoarthritis and related 
      serum inflammatory cytokines].
PG  - 493-7
LID - 10.13703/j.0255-2930.20200708-k0003 [doi]
AB  - OBJECTIVE: To compare the clinical effect of fire needling and filiform needling 
      for mild to moderate knee osteoarthritis (KOA) and observe the influence on 
      related serum inflammatory sytokines. METHODS: A total of 60 patients with mild 
      to moderate KOA were randomly divided into an observation group (30 cases, 4 
      cases dropped off) and a control group (30 cases, 4 cases dropped off). Both 
      groups were given basic health management, and the acupoints of the two groups 
      were Liangqiu (ST 34), Xuehai (SP 10), Neixiyan (EX-LE 4), Dubi (ST 35), 
      Yanglingquan (GB 34) and ashi point. The observation group was treated with fire 
      needling, while the control group was treated with filiform needling. Both groups 
      were treated once every other day, 3 times a week for 2 weeks. The Western 
      Ontario and McMaster University osteoarthritis index (WOAMC) scores of the two 
      groups were compared before treatment, in 1, 2 weeks of treatment and 2, 6 weeks 
      of follow-up. ELISA method was used to detect the levels of serum interleukin 1alpha 
      (IL-1alpha), tumor necrosis factor alpha (TNF-alpha) and matrix metalloproteinase 3 (MMP-3) 
      before treatment and in 2 weeks of treatment. The clinical effect of the two 
      groups was evaluated in 1, 2 weeks of treatment and 2, 6 weeks of follow-up. 
      RESULTS: At each time point of treatment and follow-up, the pain, stiffness, 
      difficulty of daily activities scores and WOMAC total scores of the two groups 
      were lower than those before treatment (P<0.05); the stiffness score of the 
      observation group was lower than that of the control group in 1 week of treatment 
      (P<0.05); the various scores and total scores of the WOMAC scale of the 
      observation group were lower than those of the control group in 1, 2 weeks of 
      treatment and 2, 6 weeks of follow-up (P<0.05). In 2 weeks of treatment, the 
      levels of serum MMP-3 and IL-1alpha in the observation group and IL-1alpha in the control 
      group were higher than those before treatment (P<0.05). In 1 week of treatment 
      and 2, 6 weeks of follow-up, the total effective rates of the observation group 
      were higher than those in the control group (P<0.05). CONCLUSION: Fire needling 
      can improve the pain, stiffness and joint dysfunction of patients with mild to 
      moderate KOA, and increase serum MMP-3 and IL-1alpha levels. Its short and long term 
      clinical effects are better than filiform needling.
FAU - Fu, Yuan-Bo
AU  - Fu YB
AD  - Department of Acupuncture and Moxibustion, Capital Medical University, Beijing 
      100010, China; Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 
      Hospital of TCM, Capital Medical University, Beijing 100010, China; Beijing 
      Huairou District Hospital of TCM, Beijing 101400.
FAU - Chen, Jun-Wei
AU  - Chen JW
AD  - Department of Acupuncture and Moxibustion, Capital Medical University, Beijing 
      100010, China; Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 
      Hospital of TCM, Capital Medical University, Beijing 100010, China; Beijing 
      University of CM.
FAU - Li, Bin
AU  - Li B
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of TCM, Capital 
      Medical University, Beijing 100010, China; Beijing Key Laboratory of Acupuncture 
      Neuromodulation, Beijing Hospital of TCM, Capital Medical University, Beijing 
      100010, China.
FAU - Yuan, Fang
AU  - Yuan F
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of TCM, Capital 
      Medical University, Beijing 100010, China; Beijing Key Laboratory of Acupuncture 
      Neuromodulation, Beijing Hospital of TCM, Capital Medical University, Beijing 
      100010, China.
FAU - Sun, Jing-Qing
AU  - Sun JQ
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of TCM, Capital 
      Medical University, Beijing 100010, China;Beijing Key Laboratory of Acupuncture 
      Neuromodulation, Beijing Hospital of TCM, Capital Medical University, Beijing 
      100010, China.
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - 0 (Cytokines)
SB  - IM
MH  - Acupuncture Points
MH  - *Acupuncture Therapy
MH  - Cytokines
MH  - Humans
MH  - *Osteoarthritis, Knee/therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Western Ontario and McMaster Universities osteoarthritis index (WOMAC) score
OT  - fire needling
OT  - inflammatory cytokine
OT  - knee osteoarthritis
EDAT- 2021/05/19 06:00
MHDA- 2021/05/20 06:00
CRDT- 2021/05/18 07:30
PHST- 2021/05/18 07:30 [entrez]
PHST- 2021/05/19 06:00 [pubmed]
PHST- 2021/05/20 06:00 [medline]
AID - 10.13703/j.0255-2930.20200708-k0003 [doi]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2021 May 12;41(5):493-7. doi: 
      10.13703/j.0255-2930.20200708-k0003.