PMID- 34003701
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20210520
IS  - 2169-5202 (Electronic)
IS  - 1550-0594 (Linking)
VI  - 52
IP  - 4
DP  - 2021 Jul
TI  - Short-Term Impact of Sleep Apnea/Hypopnea on the Interaction Between Various 
      Cortical Areas.
PG  - 296-306
LID - 10.1177/1550059420965441 [doi]
AB  - INTRODUCTION: Sleep apnea/hypopnea syndrome (SAHS) can change brain structure and 
      function. These alterations are related to respiratory event-induced abnormal 
      sleep, however, how brain activity changes during these events is less well 
      understood. METHODS: To study information content and interaction among various 
      cortical regions, we analyzed the variations of permutation entropy (PeEn) and 
      symbolic transfer entropy (STE) of electroencephalography (EEG) activity during 
      respiratory events. In this study, 57 patients with moderate SAHS were enrolled, 
      including 2804 respiratory events. The events terminated with cortical arousal 
      were independently researched. RESULTS: PeEn and STE were lower during 
      apnea/hypopnea, and most of the brain interaction was higher after apnea/hypopnea 
      termination than that before apnea in N2 stage. As indicated by STE, the 
      respiratory events also affected the stability of information transmission mode. 
      In N1, N2, and rapid eye movement (REM) stages, the information flow direction 
      was posterior-to-anterior, but the anterior-to-posterior increased relatively 
      during apnea/hypopnea. The above EEG activity trends maintained in events with 
      cortical arousal. CONCLUSIONS: These results may be related to the intermittent 
      hypoxia during apnea and the cortical response. Furthermore, increased frontal 
      information outflow, which was related to the compensatory activation of frontal 
      neurons, may associate with cognitive function.
FAU - Zhou, Guo-Lin
AU  - Zhou GL
AD  - School of Biomedical Engineering, 26469Sun Yat-Sen University, Guangzhou, China.
FAU - Pan, Yu
AU  - Pan Y
AD  - School of Biomedical Engineering, 26469Sun Yat-Sen University, Guangzhou, China.
FAU - Liao, Yuan-Yuan
AU  - Liao YY
AD  - School of Biomedical Engineering, 26469Sun Yat-Sen University, Guangzhou, China.
FAU - Liang, Jiu-Xing
AU  - Liang JX
AD  - Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of 
      Mental Health and Cognitive Science, Center for Studies of Psychological 
      Application, 12451South China Normal University, Guangzhou, China.
FAU - Zhang, Xiang-Min
AU  - Zhang XM
AD  - 373651Sleep-Disordered Breathing Center of the 6th Affiliated Hospital of Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Luo, Yu-Xi
AU  - Luo YX
AUID- ORCID: 0000-0003-3133-0064
AD  - School of Biomedical Engineering, 26469Sun Yat-Sen University, Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical 
      Instrument, Sun Yat-Sen University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20201014
PL  - United States
TA  - Clin EEG Neurosci
JT  - Clinical EEG and neuroscience
JID - 101213033
SB  - IM
MH  - Electroencephalography
MH  - Humans
MH  - Polysomnography
MH  - Sleep
MH  - *Sleep Apnea Syndromes
MH  - *Sleep Stages
OTO - NOTNLM
OT  - EEG
OT  - cortical activity
OT  - permutation entropy
OT  - sleep apnea hypopnea syndrome
OT  - symbolic transfer entropy
EDAT- 2021/05/19 06:00
MHDA- 2021/05/21 06:00
CRDT- 2021/05/18 17:11
PHST- 2021/05/18 17:11 [entrez]
PHST- 2021/05/19 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
AID - 10.1177/1550059420965441 [doi]
PST - ppublish
SO  - Clin EEG Neurosci. 2021 Jul;52(4):296-306. doi: 10.1177/1550059420965441. Epub 
      2020 Oct 14.