PMID- 34003911
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Feb 5
TI  - Prevalence of Focal Inner, Middle, and Combined Retinal Thinning in Diabetic 
      Patients and Its Relationship With Systemic and Ocular Parameters.
PG  - 26
LID - 10.1167/tvst.10.2.26 [doi]
LID - 26
AB  - PURPOSE: To determine the prevalence of focal inner, middle, and combined 
      inner/middle retinal thinning (FIRT, FMRT, and FCRT, respectively) in different 
      stages of diabetic retinopathy (DR) without diabetic macular edema and to assess 
      the relationship between such findings with ocular and systemic parameters. 
      METHODS: This was a cross-sectional, comparative study comprising healthy 
      participants and diabetic patients with different stages of DR. Forty-nine 
      horizontal macular B-scans from the selected eye were obtained using 
      spectral-domain optical coherence tomography (SD-OCT) and analyzed for the 
      presence of FIRT, FMRT, or FCRT and any relationship with systemic and ocular 
      parameters. Focal retinal thinning (FRT) was subjectively defined as any evidence 
      of inner and/or middle retinal thinning. RESULTS: A total of 190 participants (52 
      healthy participants and 138 diabetic patients) were included. A higher 
      prevalence of FRT was observed in eyes with advanced DR versus healthy eyes and 
      versus diabetic eyes with no DR or mild DR. FIRT and FCRT were significantly 
      greater in eyes with proliferative DR treated with pan-retinal photocoagulation, 
      and FMRT was significantly more common in eyes with severe nonproliferative DR. 
      FRT was significantly more common in patients with coronary artery disease and 
      was positively correlated with diabetes duration, serum creatinine, and 
      glycosylated hemoglobin and negatively correlated with age, estimated glomerular 
      filtration rate, and visual acuity. CONCLUSIONS: FRT occurs in all stages of DR 
      and is increasingly prevalent with increasing severity of DR. TRANSLATIONAL 
      RELEVANCE: OCT identification of FRT may provide a surrogate biomarker of retinal 
      and systemic disease in diabetic patients.
FAU - Preti, Rony Carlos
AU  - Preti RC
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Iovino, Claudio
AU  - Iovino C
AD  - Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental 
      Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy.
FAU - Abalem, Maria Fernanda
AU  - Abalem MF
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
AD  - Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.
FAU - Garcia, Rafael
AU  - Garcia R
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Veloso Dos Santos, Helen Nazareth
AU  - Veloso Dos Santos HN
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Sakuno, Gustavo
AU  - Sakuno G
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Au, Adrian
AU  - Au A
AD  - Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      USA.
FAU - Cunha, Leonardo Provetti
AU  - Cunha LP
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
AD  - Department of Ophthalmology, School of Medicine, Federal University of Juiz de 
      Fora, Juiz de Fora, Brazil.
FAU - Zacharias, Leandro Cabral
AU  - Zacharias LC
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Monteiro, Mario Luiz Ribeiro
AU  - Monteiro MLR
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Sadda, Srinivas Reddy
AU  - Sadda SR
AD  - Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      USA.
AD  - Doheny Eye Institute, Los Angeles, CA, USA.
FAU - Sarraf, David
AU  - Sarraf D
AD  - Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      USA.
AD  - Greater Los Angeles Veterans Affairs Healthcare Center, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus
MH  - *Diabetic Retinopathy/diagnosis
MH  - Humans
MH  - *Macular Edema
MH  - Prevalence
MH  - Tomography, Optical Coherence
PMC - PMC7900871
COIS- Disclosure: R.C. Preti, None; C. Iovino, None; M.F. Abalem, None; R. Garcia, 
      None; H.N. Veloso dos Santos, None; G. Sakuno, None; A. Au, None; L.P. Cunha, 
      None; L.C. Zacharias, None; M.L.R. Monteiro, None; S.R. Sadda, None; D. Sarraf, 
      None
EDAT- 2021/05/19 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/02/17
CRDT- 2021/05/18 17:22
PHST- 2021/05/18 17:22 [entrez]
PHST- 2021/05/19 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/02/17 00:00 [pmc-release]
AID - 2772294 [pii]
AID - TVST-20-2947 [pii]
AID - 10.1167/tvst.10.2.26 [doi]
PST - ppublish
SO  - Transl Vis Sci Technol. 2021 Feb 5;10(2):26. doi: 10.1167/tvst.10.2.26.