PMID- 34004003
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 10
IP  - 4
DP  - 2021 Apr 1
TI  - High-Pass Visual Acuity Loss and Macular Structure-Function Relationship in 
      Patients With Primary Open-Angle Glaucoma.
PG  - 26
LID - 10.1167/tvst.10.4.26 [doi]
LID - 26
AB  - PURPOSE: The Logarithm of the Minimum Angle of Resolution (logMAR) chart is the 
      most common clinical test for assessing central visual function in glaucoma. 
      However, based on the use of these charts, visual acuity (VA) often remains 
      normal even when severe macular damage exists. Here, we aim to investigate the 
      potential advantages of high-pass VA in detecting glaucoma compared with 
      conventional VA. METHODS: Monocular best-corrected VA measurements were compared 
      for a novel high-pass electronic VA chart (e-chart) and a conventional e-chart in 
      113 primary open-angle glaucoma (POAG) patients with normal logMAR VA and 65 
      age-similar healthy controls. One hundred thirty-nine POAG patients underwent 
      spectral-domain optical coherence tomography (SD-OCT) for measurement of macular 
      ganglion cell layer plus inner plexiform layer (GCL+IPL) thickness. 
      Structure-function relationships between OCT measurements and the two VAs were 
      compared. The enrolled eyes were divided into two groups for further analyses 
      according to macular visual field (MVF) defects, specifically two or more 
      adjacent abnormal points within the 12 central sites of 30-2 VF. RESULTS: The 
      mean deviation (MD) of 30-2 VF test was -12.77 +/- 7.47 dB for glaucoma group and 
      -1.70 +/- 1.12 dB for control group. The mean difference of the two VAs was 
      slightly larger in glaucoma group (0.29 logMAR) than in control group (0.22 
      logMAR). The area under the receiver operating characteristic curve of the 
      high-pass e-chart was larger than that of conventional e-chart (0.917 vs. 0.757, 
      P < 0.001). Significant correlations between high-pass VA and GCL+IPL thickness 
      were found only in the MVF-damaged group. Compared with conventional VA, 
      high-pass VA demonstrates stronger correlations with nasal-side macular GCL+IPL 
      thickness (Fisher's Z-test, two-tailed, P2mmin diameter = 0.033 and P3mmin 
      diameter = 0.005). CONCLUSIONS: Compared with conventional VA, high-pass VA 
      displays slightly higher sensitivity to visual loss in glaucoma and has a 
      stronger correlation with the nasal-side macular GCL+IPL thickness. TRANSLATIONAL 
      RELEVANCE: The high-pass acuity test has the potential to be used as an ancillary 
      tool to monitor glaucoma over time.
FAU - Wen, Yun
AU  - Wen Y
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Chen, Zidong
AU  - Chen Z
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Zuo, Chengguo
AU  - Zuo C
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Yang, Yangfan
AU  - Yang Y
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Xu, Jiangang
AU  - Xu J
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Kong, Yang
AU  - Kong Y
AD  - School of Electronics and Communication Engineering, Sun Yat-sen University, 
      Shenzhen, China.
FAU - Cheng, Hui
AU  - Cheng H
AD  - School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, 
      China.
FAU - Yu, Minbin
AU  - Yu M
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Glaucoma, Open-Angle/diagnosis
MH  - Humans
MH  - Nerve Fibers
MH  - Retinal Ganglion Cells
MH  - Structure-Activity Relationship
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
PMC - PMC8083119
COIS- Disclosure: Y. Wen, None; Z. Chen, None; C. Zuo, None; Y. Yang, None; J. Xu, 
      None; Y. Kong, None; H. Cheng, None; M. Yu, None
EDAT- 2021/05/19 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/04/23
CRDT- 2021/05/18 17:23
PHST- 2021/05/18 17:23 [entrez]
PHST- 2021/05/19 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/04/23 00:00 [pmc-release]
AID - 2772506 [pii]
AID - TVST-21-3358 [pii]
AID - 10.1167/tvst.10.4.26 [doi]
PST - ppublish
SO  - Transl Vis Sci Technol. 2021 Apr 1;10(4):26. doi: 10.1167/tvst.10.4.26.