PMID- 34004427
OWN - NLM
STAT- MEDLINE
DCOM- 20210602
LR  - 20210602
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 140
DP  - 2021 Jul
TI  - Dual-energy CT in predicting Ki-67 expression in laryngeal squamous cell 
      carcinoma.
PG  - 109774
LID - S0720-048X(21)00255-2 [pii]
LID - 10.1016/j.ejrad.2021.109774 [doi]
AB  - PURPOSE: To investigate whether multiple dual-energy computed tomography (DECT) 
      parameters can noninvasively predict the Ki-67 expression (associated with 
      survival and prognosis) in laryngeal squamous cell carcinoma (LSCC). METHODS: 
      Eighty-eight patients with histologically proven LSCC were retrospectively 
      reviewed. Multiple DECT-derived parameters were measured and correlated with 
      Ki-67 expression by Spearman correlation analysis. Comparisons of the 
      DECT-derived parameters between tumors with low- and high-level expression of 
      Ki-67 were made with the t-tests. RESULTS: The iodine concentration (IC), 
      normalized IC (NIC), effective atomic number (Z(eff)), 40-80 keV, and slope (k) 
      values were positively correlated with Ki-67 expression (all p < 0.05, 
      rho=0.367-0.548). Among all DECT-derived parameters, NIC value had the highest r 
      value in correlation with Ki-67 expression. The IC, NIC, Z(eff), 40-80 keV, and 
      slope (k) values were significantly higher in LSCC with high Ki-67 expression 
      than in those with low Ki-67 expression (all p < 0.05). CONCLUSIONS: Multiple 
      DECT-derived parameters (IC, NIC, Z(eff), 40-80 keV, and slope (k)) can be used 
      as predictors of survival and prognosis in LSCC, among which the NIC value is the 
      strongest.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan 
      University, Shanghai, 200031, PR China; Department of Radiology, The Affiliated 
      Renmin Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212002, PR China.
FAU - Tang, Zuohua
AU  - Tang Z
AD  - Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan 
      University, Shanghai, 200031, PR China. Electronic address: tzh518sunny@163.com.
FAU - Xiao, Zebin
AU  - Xiao Z
AD  - Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan 
      University, Shanghai, 200031, PR China; Department of Biomedical Sciences, 
      University of Pennsylvania, Philadelphia, 19104, USA.
FAU - Wu, Lingjie
AU  - Wu L
AD  - Department of Otolaryngology, Eye & ENT Hospital of Shanghai Medical School, 
      Fudan University, Shanghai, PR China.
FAU - Hong, Rujian
AU  - Hong R
AD  - Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan 
      University, Shanghai, 200031, PR China.
FAU - Duan, Fei
AU  - Duan F
AD  - Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan 
      University, Shanghai, 200031, PR China.
FAU - Wang, Yuzhe
AU  - Wang Y
AD  - Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan 
      University, Shanghai, 200031, PR China.
FAU - Zhan, Yang
AU  - Zhan Y
AD  - The Shanghai Institution of Medical Imaging, Zhongshan Hospital, Fudan 
      University, Shanghai, 200032, PR China.
LA  - eng
PT  - Journal Article
DEP - 20210512
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Ki-67 Antigen)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Iodine
MH  - Ki-67 Antigen
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Dual-energy computed tomography
OT  - Effective atomic number
OT  - Iodine concentration
OT  - Ki-67 expression
OT  - Laryngeal squamous cell carcinoma
OT  - Prognosis
OT  - Spectral attenuation curve
EDAT- 2021/05/19 06:00
MHDA- 2021/06/03 06:00
CRDT- 2021/05/18 20:30
PHST- 2021/02/22 00:00 [received]
PHST- 2021/04/15 00:00 [revised]
PHST- 2021/05/07 00:00 [accepted]
PHST- 2021/05/19 06:00 [pubmed]
PHST- 2021/06/03 06:00 [medline]
PHST- 2021/05/18 20:30 [entrez]
AID - S0720-048X(21)00255-2 [pii]
AID - 10.1016/j.ejrad.2021.109774 [doi]
PST - ppublish
SO  - Eur J Radiol. 2021 Jul;140:109774. doi: 10.1016/j.ejrad.2021.109774. Epub 2021 
      May 12.