PMID- 34005719
OWN - NLM
STAT- Publisher
LR  - 20240222
IS  - 1477-9145 (Electronic)
IS  - 0022-0949 (Linking)
DP  - 2020 Jan 1
TI  - High temperature induces transcriptomic changes in Crassostrea gigas that hinders 
      progress of Ostreid herpesvirus (OsHV-1) and promotes survival.
LID - jeb.226233 [pii]
LID - 10.1242/jeb.226233 [doi]
AB  - Among all the environmental factors, seawater temperature plays a decisive role 
      in triggering marine diseases. Like fever in vertebrates, high seawater 
      temperature could modulate the host response to the pathogens in ectothermic 
      animals. In France, massive mortality of Pacific oysters Crassostrea gigas caused 
      by the ostreid herpesvirus 1 (OsHV-1) is markedly reduced when temperatures 
      exceed 24 degrees C in the field. In the present study we assess how high temperature 
      influences the host response to the pathogen by comparing transcriptomes 
      (RNA-sequencing) during the course of experimental infection at 21 degrees C (reference) 
      and 29 degrees C. We show that high temperature induced host physiological processes that 
      are unfavorable to the viral infection. Temperature influenced the expression of 
      transcripts related to the immune process and increased the transcription of 
      genes related to apoptotic process, synaptic signaling, and protein processes at 
      29 degrees C. Concomitantly, the expression of genes associated to catabolism, 
      metabolites transport, macromolecules synthesis and cell growth remained low 
      since the first stage of infection at 29 degrees C. Moreover, viral entry into the host 
      might have been limited at 29 degrees C by changes in extracellular matrix composition 
      and protein abundance. Overall, these results provide new insights into how 
      environmental factors modulate the host-pathogen interactions.
CI  - (c) 2020. Published by The Company of Biologists Ltd.
FAU - Delisle, Lizenn
AU  - Delisle L
AD  - Ifremer, Univ Brest, CNRS, IRD, LEMAR, F-29280 Plouzane, France.
AD  - Cawthron institute, 98 Halifax street East, Private bag 2, Nelson 7042, New 
      Zealand.
FAU - Pauletto, Marianna
AU  - Pauletto M
AD  - Department of Comparative Biomedicine and Food Science. University of Padova, 
      Viale dell'Universita 16, 35020 Legnaro, Padova, Italy.
FAU - Vidal-Dupiol, Jeremie
AU  - Vidal-Dupiol J
AD  - IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, F-34095 
      Montpellier, France.
FAU - Petton, Bruno
AU  - Petton B
AD  - Ifremer, Univ Brest, CNRS, IRD, LEMAR, F-29280 Plouzane, France.
FAU - Bargelloni, Luca
AU  - Bargelloni L
AD  - Department of Comparative Biomedicine and Food Science. University of Padova, 
      Viale dell'Universita 16, 35020 Legnaro, Padova, Italy.
FAU - Montagnani, Caroline
AU  - Montagnani C
AD  - IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, F-34095 
      Montpellier, France.
FAU - Pernet, Fabrice
AU  - Pernet F
AD  - Ifremer, Univ Brest, CNRS, IRD, LEMAR, F-29280 Plouzane, France.
FAU - Corporeau, Charlotte
AU  - Corporeau C
AD  - Ifremer, Univ Brest, CNRS, IRD, LEMAR, F-29280 Plouzane, France.
FAU - Fleury, Elodie
AU  - Fleury E
AUID- ORCID: 0000-0002-8546-6680
AD  - Ifremer, Univ Brest, CNRS, IRD, LEMAR, F-29280 Plouzane, France.
LA  - eng
PT  - Journal Article
DEP - 20200101
PL  - England
TA  - J Exp Biol
JT  - The Journal of experimental biology
JID - 0243705
SB  - IM
OTO - NOTNLM
OT  - Antiviral molecular pathway
OT  - Host-pathogen interaction
OT  - Marine disease
OT  - OsHV-1
OT  - Resistance
OT  - Temperature
EDAT- 2020/01/01 00:00
MHDA- 2020/01/01 00:00
CRDT- 2021/05/18 21:25
PHST- 2020/04/06 00:00 [received]
PHST- 2020/08/07 00:00 [accepted]
PHST- 2021/05/18 21:25 [entrez]
PHST- 2020/01/01 00:00 [pubmed]
PHST- 2020/01/01 00:00 [medline]
AID - 267727 [pii]
AID - 10.1242/jeb.226233 [doi]
PST - aheadofprint
SO  - J Exp Biol. 2020 Jan 1:jeb.226233. doi: 10.1242/jeb.226233.