PMID- 34006867
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 May 18
TI  - Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis 
      patients.
PG  - 10549
LID - 10.1038/s41598-021-88821-4 [doi]
LID - 10549
AB  - Anemia is commonly present in hemodialysis (HD) patients and significantly 
      affects their survival and quality of life. NIR spectroscopy and machine learning 
      were used as a method to detect anemia in hemodialysis patients. The aim of this 
      investigation has been to evaluate the near-infrared spectroscopy (NIRS) as a 
      method for non-invasive on-line detection of anemia parameters from HD effluent 
      by assessing the correlation between the spectrum of spent dialysate in the 
      wavelength range of 700-1700 nm and the levels of hemoglobin (Hb), red blood 
      cells (RBC), hematocrit (Hct), iron (Fe), total iron binding capacity (TIBC), 
      ferritin (FER), mean corpuscular volume (MCV) and mean corpuscular hemoglobin 
      concentration (MCHC) in patient blood. The obtained correlation coefficient (R) 
      for RBC was 0.93, for Hb 0.92, for Fe 0.94, for TIBC 0.96, for FER 0.91, for Hct 
      0.94, for MCV 0.92, for MCHC 0.92 and for MCH 0.93. The observed high 
      correlations between the NIR spectrum of the dialysate fluid and the levels of 
      the studied variables support the use of NIRS as a promising method for on-line 
      monitoring of anemia and iron saturation parameters in HD patients.
FAU - Matovic, Valentina
AU  - Matovic V
AD  - Faculty of Mechanical Engineering, Belgrade University, Kraljice Marije 16, 
      11120, Belgrade, Serbia. vmatovic@mas.bg.ac.rs.
FAU - Jeftic, Branislava
AU  - Jeftic B
AD  - Faculty of Mechanical Engineering, Belgrade University, Kraljice Marije 16, 
      11120, Belgrade, Serbia.
FAU - Trbojevic-Stankovic, Jasna
AU  - Trbojevic-Stankovic J
AD  - Faculty of Medicine, Belgrade University, Dr Subotica 8, 11000, Belgrade, Serbia.
AD  - Clinic of Urology, University Hospital Center "Dr Dragisa Misovic-Dedinje", 
      Heroja Milana Tepica 1, 11000, Belgrade, Serbia.
FAU - Matija, Lidija
AU  - Matija L
AD  - Faculty of Mechanical Engineering, Belgrade University, Kraljice Marije 16, 
      11120, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20210518
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Anemia, Iron-Deficiency/blood/*therapy
MH  - Erythrocyte Indices
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Monitoring, Physiologic/methods
MH  - Quality of Life
MH  - *Renal Dialysis
MH  - Spectroscopy, Near-Infrared/*methods
PMC - PMC8131692
COIS- The authors declare no competing interests.
EDAT- 2021/05/20 06:00
MHDA- 2021/11/09 06:00
PMCR- 2021/05/18
CRDT- 2021/05/19 06:15
PHST- 2020/10/12 00:00 [received]
PHST- 2021/04/08 00:00 [accepted]
PHST- 2021/05/19 06:15 [entrez]
PHST- 2021/05/20 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2021/05/18 00:00 [pmc-release]
AID - 10.1038/s41598-021-88821-4 [pii]
AID - 88821 [pii]
AID - 10.1038/s41598-021-88821-4 [doi]
PST - epublish
SO  - Sci Rep. 2021 May 18;11(1):10549. doi: 10.1038/s41598-021-88821-4.