PMID- 34007321
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210520
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 22
IP  - 1
DP  - 2021 Jul
TI  - Tolerogenic dendritic cells suppress titanium particle-induced inflammation.
PG  - 712
LID - 10.3892/etm.2021.10144 [doi]
LID - 712
AB  - Aseptic loosening is a major complication of prosthetic joint surgery. The 
      leading cause of arthroplasty failure is particulate wear debris such as titanium 
      particles. Dendritic cells (DCs) are one type of immune cells that play an 
      important role in the initiation and progression of inflammatory processes. DCs 
      can develop into tolerogenic DCs (tolDCs), which present an alternative 
      therapeutic strategy for inflammatory disorders. Previously, antigen-specific 
      tolDCs were generated, which showed a promising effect in treating inflammatory 
      arthritis and immune thrombocytopenia. The present study reports that tolDCs 
      effectively inhibited titanium particle-induced inflammation in an air-pouch 
      mouse model by decreasing pro-inflammatory cytokines. In addition, a mechanistic 
      study demonstrated that tolDCs significantly protected against titanium 
      particle-induced inflammatory processes in vitro by releasing anti-inflammatory 
      cytokines, such as interleukin-10. Collectively, these findings not only 
      demonstrate that tolDCs play an important role in inhibiting titanium 
      particle-induced inflammation but also provide a potential alternative for the 
      prevention or treatment of titanium particle-induced inflammation.
CI  - Copyright: (c) Wang et al.
FAU - Wang, Wenzhao
AU  - Wang W
AD  - Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, P.R. China.
AD  - Department of Emergency Medicine, The Second Affiliated Hospital of Shandong 
      First Medical University, Taian, Shandong 271000, P.R. China.
FAU - Han, Bing
AU  - Han B
AD  - Department of Orthopedic, Jinan Central Hospital Affiliated to Shandong First 
      Medical University, Jinan Central Hospital Affiliated to Shandong University, 
      Jinan, Shandong 250013, P.R. China.
AD  - Department of Orthopedics, Zoucheng People's Hospital, Zoucheng, Shandong 273500, 
      P.R. China.
FAU - Chen, Jianan
AU  - Chen J
AD  - Department of Orthopedic, Jinan Central Hospital Affiliated to Shandong First 
      Medical University, Jinan Central Hospital Affiliated to Shandong University, 
      Jinan, Shandong 250013, P.R. China.
FAU - Tian, Huichao
AU  - Tian H
AD  - Department of Orthopedic, Qilu Hospital, Cheeloo College of Medicine, Shandong 
      University, Jinan, Shandong 250012, P.R. China.
FAU - Sun, Mingjie
AU  - Sun M
AD  - Department of Orthopedic, Jinan Central Hospital Affiliated to Shandong First 
      Medical University, Jinan Central Hospital Affiliated to Shandong University, 
      Jinan, Shandong 250013, P.R. China.
FAU - Jiang, Yunpeng
AU  - Jiang Y
AD  - Department of Orthopedic, Qilu Hospital, Cheeloo College of Medicine, Shandong 
      University, Jinan, Shandong 250012, P.R. China.
FAU - Xie, Wei
AU  - Xie W
AD  - Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, P.R. China.
AD  - Department of Emergency Medicine, The Second Affiliated Hospital of Shandong 
      First Medical University, Taian, Shandong 271000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20210503
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC8120651
OTO - NOTNLM
OT  - air-pouch model
OT  - inflammation
OT  - titanium particle
OT  - tolDCs
COIS- The authors declare that they have no competing interests.
EDAT- 2021/05/20 06:00
MHDA- 2021/05/20 06:01
PMCR- 2021/05/03
CRDT- 2021/05/19 06:47
PHST- 2020/06/07 00:00 [received]
PHST- 2021/03/10 00:00 [accepted]
PHST- 2021/05/19 06:47 [entrez]
PHST- 2021/05/20 06:00 [pubmed]
PHST- 2021/05/20 06:01 [medline]
PHST- 2021/05/03 00:00 [pmc-release]
AID - ETM-0-0-10144 [pii]
AID - 10.3892/etm.2021.10144 [doi]
PST - ppublish
SO  - Exp Ther Med. 2021 Jul;22(1):712. doi: 10.3892/etm.2021.10144. Epub 2021 May 3.