PMID- 34007406
OWN - NLM
STAT- MEDLINE
DCOM- 20211112
LR  - 20220404
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2021
DP  - 2021
TI  - Salvia miltiorrhiza and the Volatile of Dalbergia odorifera Attenuate Chronic 
      Myocardial Ischemia Injury in a Pig Model: A Metabonomic Approach for the 
      Mechanism Study.
PG  - 8840896
LID - 10.1155/2021/8840896 [doi]
LID - 8840896
AB  - Salvia miltiorrhiza (SM) coupled with Dalbergia odorifera (DO) has been used to 
      relieve cardiovascular diseases in China for many years. Our previous studies 
      have integrated that SM-the volatile oil of DO (SM-DOO)-has a cardioprotective 
      effect on chronic myocardial ischemia based on a pharmacological method, but the 
      cardioprotective mechanism has not been elucidated completely in the metabonomic 
      method. In the present study, a metabonomic method based on high-performance 
      liquid chromatography time-of-flight mass spectrometry (HPLC-Q-TOF-MS) was 
      performed to evaluate the effects of SM-DOO on chronic myocardial ischemia 
      induced by an ameroid constrictor, which was placed on the left anterior 
      descending coronary artery (LAD) of pigs. Pigs were divided into three groups: 
      sham, model, and SM-DOO group. With multivariate analysis, a clear cluster among 
      the different groups was obtained and the potential biomarkers were recognized. 
      These biomarkers were mainly related to energy metabolism, glucose metabolism, 
      and fatty acid metabolism. Furthermore, the protein expressions of phosphorylated 
      AMP-activated protein kinase (p-AMPK) and glucose transporter-4 (GLUT4) were 
      significantly upregulated by SM-DOO. The result indicated that SM-DOO could 
      regulate the above biomarkers and metabolic pathways, especially energy 
      metabolism and glucose metabolism. By analyzing and verifying the biomarkers and 
      metabolic pathways, further understanding of the cardioprotective effect of 
      SM-DOO with its mechanism was evaluated. Metabonomic is a reliable system biology 
      approach for understanding the cardioprotective effects of SM-DOO on chronic 
      myocardial ischemia and elucidating the mechanism underlying this protective 
      effect.
CI  - Copyright (c) 2021 Rui Lin et al.
FAU - Lin, Rui
AU  - Lin R
AUID- ORCID: 0000-0001-7213-3986
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Mu, Fei
AU  - Mu F
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Li, Yao
AU  - Li Y
AD  - Northwest University, Faculty of Life Science & Medicine, Key Laboratory Resource 
      Biology & Biotechnology in Western China, Ministry of Education, Xi'an, Shaanxi 
      710069, China.
FAU - Duan, Jialin
AU  - Duan J
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Zhao, Meina
AU  - Zhao M
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Guan, Yue
AU  - Guan Y
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Liu, Kedi
AU  - Liu K
AD  - College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 
      712046, China.
FAU - Bai, Yang
AU  - Bai Y
AD  - National Drug Clinical Trial Institute, The Second Affiliated Hospital, Shaanxi 
      University of Chinese Medicine, Xianyang 712000, China.
FAU - Wen, Aidong
AU  - Wen A
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Wei, Peifeng
AU  - Wei P
AUID- ORCID: 0000-0002-7261-7304
AD  - National Drug Clinical Trial Institute, The Second Affiliated Hospital, Shaanxi 
      University of Chinese Medicine, Xianyang 712000, China.
FAU - Wang, Jingwen
AU  - Wang J
AUID- ORCID: 0000-0002-3450-9046
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Xi, Miaomiao
AU  - Xi M
AUID- ORCID: 0000-0002-4367-2056
AD  - National Drug Clinical Trial Institute, The Second Affiliated Hospital, Shaanxi 
      University of Chinese Medicine, Xianyang 712000, China.
AD  - TANK Medicinal Biology Institute of Xi'an, Xi'an, Shaanxi 710032, China.
LA  - eng
PT  - Journal Article
DEP - 20210428
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
SB  - IM
EIN - Oxid Med Cell Longev. 2022 Mar 23;2022:9763253. PMID: 35368877
MH  - Animals
MH  - Dalbergia/*chemistry
MH  - Disease Models, Animal
MH  - Male
MH  - Metabolomics/*methods
MH  - Myocardial Reperfusion Injury/*physiopathology
MH  - Salvia miltiorrhiza/*chemistry
MH  - Swine
PMC - PMC8099511
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2021/05/20 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/04/28
CRDT- 2021/05/19 06:48
PHST- 2020/09/08 00:00 [received]
PHST- 2021/03/31 00:00 [revised]
PHST- 2021/04/12 00:00 [accepted]
PHST- 2021/05/19 06:48 [entrez]
PHST- 2021/05/20 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/04/28 00:00 [pmc-release]
AID - 10.1155/2021/8840896 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2021 Apr 28;2021:8840896. doi: 10.1155/2021/8840896. 
      eCollection 2021.