PMID- 34011394
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20240402
IS  - 2046-4053 (Electronic)
IS  - 2046-4053 (Linking)
VI  - 10
IP  - 1
DP  - 2021 May 20
TI  - Effectiveness of matching human leukocyte antigens (HLA) in corneal 
      transplantation: a systematic review protocol.
PG  - 150
LID - 10.1186/s13643-021-01704-7 [doi]
LID - 150
AB  - BACKGROUND: Corneal transplantation is the most frequently performed 
      transplantation in the UK. Despite this, the therapeutic value of matching human 
      leukocyte antigen (HLA) subtypes for transplanted corneas remains controversial. 
      Ocular immune privilege was originally deemed to render matching unnecessary; 
      however, more recently, matching has demonstrated improved outcomes including 
      graft success, amongst others. This systematic review aims to evaluate the 
      effectiveness of major and minor antigen matching on graft outcomes in corneal 
      transplantation. METHODS: Standard systematic review methodology will be used to 
      identify, select and extract data from observational studies and clinical trials 
      assessing the effects of HLA matching on corneal graft outcomes. Bibliographic 
      databases (Cochrane Library, EMBASE, MEDLINE, Web of Science, Scopus), clinical 
      trial registers, abstract and conference proceedings, in addition to 
      dissertation, thesis and grey literature will be searched. Neither date of 
      publication nor language will be restricted, and non-English articles will be 
      translated where necessary. The primary outcome will be to assess corneal graft 
      success for different degrees of HLA matching/mismatching. The precise end 
      outcome measure varies amongst studies and includes graft rejection, 
      immunoreaction, failure and survival. Therefore, data will be extracted across 
      all relevant outcome parameters and grouped for subsequent statistical tests. 
      Risk of bias assessment will be completed, appropriate to each study design. 
      Study selection, data extraction and risk of bias assessment will be 
      independently completed by two reviewers. Data will be tabulated, and a narrative 
      synthesis presented. Meta-analysis will be performed where there is sufficient 
      homogeneity between studies to warrant its effective completion. Subgroup and 
      sensitivity analysis will be undertaken if appropriate. DISCUSSION: Many studies 
      have investigated the effectiveness of HLA matching for corneal transplantation. 
      A systematic review is needed to collate and analyse this evidence. Findings of 
      this systematic review may form the basis of evidence-based recommendations on 
      pre-operative HLA typing and matching of corneal grafts for transplantation. 
      SYSTEMATIC REVIEW REGISTRATION: PROSPERO reference CRD42020198882.
FAU - Sachdeva, Gagandeep Singh
AU  - Sachdeva GS
AD  - Institute of Clinical Sciences, College of Medical and Dental Sciences, 
      University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
FAU - Cabada, Joshua Piollo
AU  - Cabada JP
AD  - Institute of Clinical Sciences, College of Medical and Dental Sciences, 
      University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
FAU - Karim, Syed Saad
AU  - Karim SS
AD  - Institute of Clinical Sciences, College of Medical and Dental Sciences, 
      University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
FAU - Kahandawa, Dmitry Lakvin
AU  - Kahandawa DL
AD  - Institute of Clinical Sciences, College of Medical and Dental Sciences, 
      University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
FAU - Thomas, Kevin Anil
AU  - Thomas KA
AD  - Institute of Clinical Sciences, College of Medical and Dental Sciences, 
      University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
FAU - Kumar, Anusha
AU  - Kumar A
AD  - Institute of Clinical Sciences, College of Medical and Dental Sciences, 
      University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
FAU - Barry, Robert J
AU  - Barry RJ
AUID- ORCID: 0000-0002-6435-0048
AD  - Institute of Clinical Sciences, College of Medical and Dental Sciences, 
      University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. 
      R.J.Barry@bham.ac.uk.
AD  - Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, University 
      of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. R.J.Barry@bham.ac.uk.
FAU - Butt, Gibran Farook
AU  - Butt GF
AD  - Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, University 
      of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. G.F.Butt@bham.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20210520
PL  - England
TA  - Syst Rev
JT  - Systematic reviews
JID - 101580575
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Corneal Transplantation
MH  - Graft Rejection/prevention & control
MH  - *HLA Antigens
MH  - Histocompatibility Antigens Class II
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Systematic Reviews as Topic
PMC - PMC8136040
OTO - NOTNLM
OT  - Antigen matching
OT  - Corneal transplantation, Keratoplasty
OT  - Failure
OT  - HLA matching
OT  - Meta-analysis
OT  - Reaction
OT  - Rejection
OT  - Survival
OT  - Systematic review
COIS- The authors declare that they have no competing interests.
EDAT- 2021/05/21 06:00
MHDA- 2021/07/06 06:00
PMCR- 2021/05/20
CRDT- 2021/05/20 05:41
PHST- 2020/10/23 00:00 [received]
PHST- 2021/05/13 00:00 [accepted]
PHST- 2021/05/20 05:41 [entrez]
PHST- 2021/05/21 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2021/05/20 00:00 [pmc-release]
AID - 10.1186/s13643-021-01704-7 [pii]
AID - 1704 [pii]
AID - 10.1186/s13643-021-01704-7 [doi]
PST - epublish
SO  - Syst Rev. 2021 May 20;10(1):150. doi: 10.1186/s13643-021-01704-7.