PMID- 34012420
OWN - NLM
STAT- MEDLINE
DCOM- 20220121
LR  - 20220121
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Altered White Matter Microstructures in Type 2 Diabetes Mellitus: A 
      Coordinate-Based Meta-Analysis of Diffusion Tensor Imaging Studies.
PG  - 658198
LID - 10.3389/fendo.2021.658198 [doi]
LID - 658198
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) is often accompanied by cognitive 
      decline and depressive symptoms. Numerous diffusion tensor imaging (DTI) studies 
      revealed microstructural white matter (WM) abnormalities in T2DM but the findings 
      were inconsistent. The present study aimed to conduct a coordinate-based 
      meta-analysis (CBMA) to identify statistical consensus of DTI studies in T2DM. 
      METHODS: We performed a systematic search on relevant studies that reported 
      fractional anisotropy (FA) differences between T2DM patients and healthy controls 
      (HC). The anisotropic effect size seed-based d mapping (AES-SDM) approach was 
      used to explore WM alterations in T2DM. A meta-regression was then used to 
      analyze potential influences of sample characteristics on regional FA changes. 
      RESULTS: A total of eight studies that comprised 245 patients and 200 HC, along 
      with 52 coordinates were extracted. The meta-analysis identified FA reductions in 
      three clusters including the left inferior network, the corpus callosum (CC), and 
      the left olfactory cortex. Besides, FA in the CC was negatively correlated with 
      body mass index (BMI) in the patients group. CONCLUSIONS: T2DM could lead to 
      subtle WM microstructural alterations, which might be associated with cognitive 
      deficits or emotional distress symptoms. This provides a better understanding of 
      the pathophysiology of neurodegeneration and complications in T2DM. SYSTEMATIC 
      REVIEW REGISTRATION: Registered at PROSPERO (http://www.crd.york.ac.uk/PROSPERO), 
      registration number: CRD42020218737.
CI  - Copyright (c) 2021 Zhou, Li, Dong, Ping, Lin, Wang, Wang, Gao, Yu, Cheng and Xu.
FAU - Zhou, Cong
AU  - Zhou C
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Psychiatry, Jining Psychiatric Hospital, Jining, China.
FAU - Dong, Man
AU  - Dong M
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Ping, Liangliang
AU  - Ping L
AD  - Department of Psychiatry, Xiamen Xianyue Hospital, Xiamen, China.
FAU - Lin, Hao
AU  - Lin H
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Wang, Yuxin
AU  - Wang Y
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Wang, Shuting
AU  - Wang S
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Gao, Shuo
AU  - Gao S
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Yu, Ge
AU  - Yu G
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Cheng, Yuqi
AU  - Cheng Y
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Xu, Xiufeng
AU  - Xu X
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
LA  - eng
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20210503
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anisotropy
MH  - Body Mass Index
MH  - Cognition
MH  - Corpus Callosum/diagnostic imaging
MH  - Diabetes Mellitus, Type 2/*diagnostic imaging/physiopathology/psychology
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - White Matter/anatomy & histology/*diagnostic imaging/physiopathology
MH  - Young Adult
PMC - PMC8127836
OTO - NOTNLM
OT  - diffusion tensor imaging
OT  - fractional anisotropy
OT  - meta-analysis
OT  - type 2 diabetes mellitus
OT  - white matter
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/05/21 06:00
MHDA- 2022/01/22 06:00
PMCR- 2021/01/01
CRDT- 2021/05/20 06:40
PHST- 2021/01/25 00:00 [received]
PHST- 2021/04/07 00:00 [accepted]
PHST- 2021/05/20 06:40 [entrez]
PHST- 2021/05/21 06:00 [pubmed]
PHST- 2022/01/22 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.658198 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2021 May 3;12:658198. doi: 
      10.3389/fendo.2021.658198. eCollection 2021.