PMID- 34013757
OWN - NLM
STAT- MEDLINE
DCOM- 20210521
LR  - 20210605
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 49
IP  - 5
DP  - 2021 May
TI  - Pooled platelet concentrates provide a small benefit over single-donor platelets 
      for patients with platelet refractoriness of any etiology.
PG  - 3000605211016748
LID - 10.1177/03000605211016748 [doi]
LID - 03000605211016748
AB  - BACKGROUND: At our institution, patients with platelet refractoriness (of any 
      etiology) are sometimes switched from apheresis platelets to pooled platelets 
      before human leukocyte antigen (HLA)-matched units become available. STUDY DESIGN 
      AND METHODS: Seven patients were analyzed. Platelet counts were available from 57 
      single-unit transfusions (26 pooled, 31 apheresis). A mixed linear effects model 
      was used and significance was determined using a likelihood ratio test. RESULTS: 
      When analyzed as the only fixed effect in the model, the use of pooled versus 
      single-donor units and time from transfusion to post-transfusion blood sampling 
      each showed a significant effect on platelet count increments. A mixed linear 
      effect model including both factors showed that transfusing a pooled unit 
      correlated with a 4500+/-2000/microL greater platelet count increment compared with a 
      single-donor unit, and an increase in time from transfusion to post-transfusion 
      blood sampling lowered the platelet count increment by 300+/-100/microL per hour. 
      CONCLUSION: A small but potentially clinically relevant benefit was observed in 
      transfusing pooled random-donor platelets compared with single-donor units for 
      patients with platelet refractoriness (of any etiology).
FAU - Chu, Ying-Hsia
AU  - Chu YH
AD  - Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, 
      WI, USA.
FAU - Rose, William Nicholas
AU  - Rose WN
AUID- ORCID: 0000-0002-5978-1927
AD  - Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, 
      WI, USA.
FAU - Nawrot, William
AU  - Nawrot W
AD  - Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, 
      WI, USA.
FAU - Raife, Thomas J
AU  - Raife TJ
AD  - Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, 
      WI, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Blood Platelets
MH  - HLA Antigens
MH  - Humans
MH  - Platelet Count
MH  - Platelet Transfusion
MH  - *Thrombocytopenia
PMC - PMC8142527
OTO - NOTNLM
OT  - Platelet refractoriness
OT  - alloantibody
OT  - apheresis
OT  - human leukocyte antigen
OT  - platelet transfusion
OT  - pooled
OT  - random donor
COIS- Declaration of conflicting interest: The authors declare that there is no 
      conflict of interest.
EDAT- 2021/05/21 06:00
MHDA- 2021/05/22 06:00
PMCR- 2021/05/20
CRDT- 2021/05/20 08:40
PHST- 2021/05/20 08:40 [entrez]
PHST- 2021/05/21 06:00 [pubmed]
PHST- 2021/05/22 06:00 [medline]
PHST- 2021/05/20 00:00 [pmc-release]
AID - 10.1177_03000605211016748 [pii]
AID - 10.1177/03000605211016748 [doi]
PST - ppublish
SO  - J Int Med Res. 2021 May;49(5):3000605211016748. doi: 10.1177/03000605211016748.