PMID- 34014973
OWN - NLM
STAT- MEDLINE
DCOM- 20211027
LR  - 20211027
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 5
DP  - 2021
TI  - Testis structure, duration of spermatogenesis and daily sperm production in four 
      wild cricetid rodent species (A. cursor, A. montensis, N. lasiurus, and O. 
      nigripes).
PG  - e0251256
LID - 10.1371/journal.pone.0251256 [doi]
LID - e0251256
AB  - Although rodents represent approximately 40% of all living mammalian species, our 
      knowledge regarding their reproductive biology is still scarce. Due to their high 
      vulnerability to environmental changes, wild rodents have become beneficial 
      models for ecological studies. Thus, we aimed to comparatively investigate key 
      functional testis parameters in four sexually mature wild rodent species (A. 
      cursor, A. montensis, N. lasiurus, and O. nigripes). These species belong to the 
      Cricetidae family, which is the most diverse family of rodents in South America, 
      with a total of ~120 species in Brazil. The results found for the gonadosomatic 
      index and the sickled sperm head shape observed strongly suggest that the species 
      here evaluated are promiscuous, prolific, and short-lived. The duration of 
      spermatogenesis was relatively short and varied from ~35-40 days. Both the 
      percentage of seminiferous tubules (ST) in the testis parenchyma (~95-97%) and 
      the number of Sertoli cells (SC) (~48-70 million) per testis gram were very high, 
      whereas a fairly good SC efficiency (~8-13 round spermatids per SC) was observed. 
      In comparison to other mammalian species studied, particularly the rodents of the 
      suborder Myomorpha (i.e. hamsters, rats and mice), the rodents herein 
      investigated exhibited very high (~62-80 million) daily sperm production per 
      testis gram. This impressive spermatogenic efficiency resulted mainly from the 
      short duration of spermatogenesis and quite high values found for the ST 
      percentage in the testis and the SC number per testis gram. We expect that the 
      knowledge here obtained will help conservation programs and the proper management 
      of wildlife.
FAU - Cordeiro, Dirceu A Jr
AU  - Cordeiro DA Jr
AUID- ORCID: 0000-0002-3691-5582
AD  - Laboratory of Cellular Biology, Department of Morphology, Institute of Biological 
      Sciences, Federal University of Minas Gerais-UFMG, Belo Horizonte, MG, Brazil.
AD  - UNINCOR, Tres Coracoes, MG, Brazil.
FAU - Costa, Guilherme M J
AU  - Costa GMJ
AD  - Laboratory of Cellular Biology, Department of Morphology, Institute of Biological 
      Sciences, Federal University of Minas Gerais-UFMG, Belo Horizonte, MG, Brazil.
FAU - Franca, Luiz R
AU  - Franca LR
AUID- ORCID: 0000-0003-4244-9984
AD  - Laboratory of Cellular Biology, Department of Morphology, Institute of Biological 
      Sciences, Federal University of Minas Gerais-UFMG, Belo Horizonte, MG, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210520
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Arvicolinae/*metabolism/physiology
MH  - Brazil
MH  - Leydig Cells/metabolism
MH  - Male
MH  - Seminiferous Epithelium/metabolism
MH  - Seminiferous Tubules/metabolism
MH  - Sertoli Cells/metabolism
MH  - Spermatids/metabolism
MH  - Spermatogenesis/*physiology
MH  - Spermatozoa/metabolism
MH  - Testis/*cytology
PMC - PMC8136699
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/05/21 06:00
MHDA- 2021/10/28 06:00
PMCR- 2021/05/20
CRDT- 2021/05/20 18:11
PHST- 2020/09/24 00:00 [received]
PHST- 2021/04/23 00:00 [accepted]
PHST- 2021/05/20 18:11 [entrez]
PHST- 2021/05/21 06:00 [pubmed]
PHST- 2021/10/28 06:00 [medline]
PHST- 2021/05/20 00:00 [pmc-release]
AID - PONE-D-20-29251 [pii]
AID - 10.1371/journal.pone.0251256 [doi]
PST - epublish
SO  - PLoS One. 2021 May 20;16(5):e0251256. doi: 10.1371/journal.pone.0251256. 
      eCollection 2021.