PMID- 34015764
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20240226
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 10
DP  - 2021 May 18
TI  - Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) 
      progression by modulating the miR-588/CXCR4 axis.
PG  - 14078-14087
LID - 10.18632/aging.203025 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is a common head and neck cancer with a 
      high metastasis and poor prognosis. Circular RNAs (circRNAs) are a type of 
      non-coding RNAs (ncRNAs) with regulatory function and broadly participate in 
      cancer development. However, the correlation of circular RNA ABCB10 (circABCB10) 
      with LSCC remains unclear. Here, we were interested in the role of circABCB10 in 
      the modulation of LSCC progression. Our data demonstrated that the depletion of 
      circABCB10 significantly inhibited the proliferation and induced the apoptosis of 
      LSCC cells. Meanwhile, circABCB10 knockdown was able to remarkably reduce the 
      invasion and migration of LSCC cells. Mechanically, circABCB10 served as a sponge 
      for microRNAs-588 (miR-588) and miR-588 could target and down-regulated chemokine 
      receptor 4 (CXCR4) expression in LSCC cells. The overexpression of CXCR4 or 
      miR-588 inhibitor could reverse circABCB10 depletion-attenuated malignant 
      phenotypes of LSCC cells. Functionally, the depletion of circABCB10 alleviated 
      the tumor growth of LSCC cells in the tumorigenicity analysis of nude mice. The 
      CXCR4 expression was decreased while the miR-588 expression was enhanced by 
      circABCB10 depletion in vivo. Thus, we concluded that circABCB10 was involved in 
      the malignant progression of LSCC by regulating miR-588/CXCR4 axis. Our finding 
      provides new insights into the mechanism of circRHOT1 contributing to the 
      development of LSCC. CircABCB10 and miR-588 may be used as potential targets for 
      the treatment of LSCC.
FAU - Zhao, Jin
AU  - Zhao J
AD  - Department of Oncology, Cangzhou Central Hospital, Cangzhou, Hebei, China.
FAU - Li, Xing-De
AU  - Li XD
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou, Hebei, 
      China.
FAU - Wang, Ming
AU  - Wang M
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou, Hebei, 
      China.
FAU - Song, Li-Na
AU  - Song LN
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou, Hebei, 
      China.
FAU - Zhao, Mei-Jiao
AU  - Zhao MJ
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou, Hebei, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210518
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (CXCR4 protein, human)
RN  - 0 (MIRN588 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics
MH  - Base Sequence
MH  - Carcinoma, Squamous Cell/*genetics/*pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - *Disease Progression
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/*pathology
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - MicroRNAs/genetics/*metabolism
MH  - Neoplasm Invasiveness
MH  - Receptors, CXCR4/genetics/*metabolism
MH  - Mice
PMC - PMC8202875
OTO - NOTNLM
OT  - CXCR4
OT  - circABCB10
OT  - laryngeal squamous cell carcinoma
OT  - miR-588
OT  - progression
COIS- CONFLICTS OF INTEREST: The authors declare no conflicts of interest related to 
      this study.
EDAT- 2021/05/21 06:00
MHDA- 2021/07/21 06:00
PMCR- 2021/05/31
CRDT- 2021/05/20 20:29
PHST- 2021/02/01 00:00 [received]
PHST- 2021/04/22 00:00 [accepted]
PHST- 2021/05/21 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
PHST- 2021/05/20 20:29 [entrez]
PHST- 2021/05/31 00:00 [pmc-release]
AID - 203025 [pii]
AID - 10.18632/aging.203025 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 May 18;13(10):14078-14087. doi: 10.18632/aging.203025. 
      Epub 2021 May 18.