PMID- 34016038
OWN - NLM
STAT- MEDLINE
DCOM- 20211221
LR  - 20220323
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 21
IP  - 1
DP  - 2021 May 20
TI  - Association of arterial stiffness with incident atrial fibrillation: a cohort 
      study.
PG  - 247
LID - 10.1186/s12872-021-02057-8 [doi]
LID - 247
AB  - BACKGROUND: Stiff arteries increase left ventricular (LV) end-systolic workload, 
      leading over time to left atrial and ventricular remodeling, and providing the 
      substrate for atrial fibrillation (AF) development. We investigated if carotid 
      femoral pulse wave velocity (cfPWV), a measure of central arterial stiffness, is 
      associated with incident AF. METHODS: In 2011-2013, cfPWV was measured in 3882 
      participants of the Atherosclerosis Risk in Communities Cohort Study (ARIC) 
      without prevalent AF. Participants were followed through 2017 for the incidence 
      of AF. Individuals were categorized in cfPWV quartiles based on visit 
      measurements. Multivariable Cox regression models were used to evaluate the 
      association of cfPWV with incident AF. RESULTS: Mean age was 75 years (SD 5), 60% 
      were female and 20% were African American. Over a median follow-up of 5.5 years 
      we identified 331 incident cases of AF. cfPWV demonstrated U-shaped associations 
      with AF risk. In models adjusted for age, race, center, sex, education levels, 
      and hemodynamic and clinical factors, hazard ratios (HR) of AF for participants 
      in the first, third and fourth quartiles were 1.49 (95% CI 1.06, 2.10), 1.59 
      (1.14, 2.10), and 1.56(1.10, 2.19), respectively, compared to those in the second 
      quartile. CONCLUSION: Among community-dwelling older adults, low and high central 
      arterial stiffness is associated with AF risk.
FAU - Almuwaqqat, Zakaria
AU  - Almuwaqqat Z
AD  - Department of Epidemiology, Rollins School of Public Health, Emory University, 
      Atlanta, GA, USA. zalmuwa@emory.edu.
AD  - Department of Medicine, Division of Cardiology, Emory School of Medicine, 1364 
      Clifton Rd NE, Atlanta, GA, 30322, USA. zalmuwa@emory.edu.
FAU - Claxton, J 'Neka S
AU  - Claxton J'S
AD  - Department of Epidemiology, Rollins School of Public Health, Emory University, 
      Atlanta, GA, USA.
FAU - Norby, Faye L
AU  - Norby FL
AD  - Division of Epidemiology & Community Health, School of Public Health, University 
      of Minnesota, Minneapolis, MN, USA.
FAU - Lutsey, Pamela L
AU  - Lutsey PL
AD  - Division of Epidemiology & Community Health, School of Public Health, University 
      of Minnesota, Minneapolis, MN, USA.
FAU - Wei, Jingkai
AU  - Wei J
AD  - Department of Epidemiology and Biostatistics, George Washington University, 
      Washington, D.C, USA.
FAU - Soliman, Elsayed Z
AU  - Soliman EZ
AD  - Epidemiological Cardiology Research Center, Department of Epidemiology and 
      Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
FAU - Chen, Lin Y
AU  - Chen LY
AD  - Division of Epidemiology & Community Health, School of Public Health, University 
      of Minnesota, Minneapolis, MN, USA.
AD  - Cardiovascular Division, Department of Medicine, University of Minnesota Medical 
      School, Minneapolis, MN, USA.
FAU - Matsushita, Kunihiro
AU  - Matsushita K
AD  - Department of Epidemiology and the Welch Center for Prevention, Epidemiology and 
      Clinical Research, Johns Hopkins Bloomberg School of Public Health and the 
      Division of General Internal Medicine, Department of Medicine, Johns Hopkins 
      University, Baltimore, MD, USA.
FAU - Heiss, Gerardo
AU  - Heiss G
AD  - Department of Epidemiology, Gilling's School Public Health, University of North 
      Carolina, Chapel Hill, NC, USA.
FAU - Alonso, Alvaro
AU  - Alonso A
AD  - Department of Epidemiology, Rollins School of Public Health, Emory University, 
      Atlanta, GA, USA.
LA  - eng
GR  - 16EIA26410001/AHA/American Heart Association-American Stroke Association/United 
      States
GR  - K24 HL148521/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210520
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/diagnosis/*epidemiology/physiopathology
MH  - Atrial Function, Left
MH  - Atrial Remodeling
MH  - Carotid-Femoral Pulse Wave Velocity
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - United States/epidemiology
MH  - *Vascular Stiffness
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
PMC - PMC8139144
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Atrial fibrillation
OT  - Hypertension
COIS- None.
EDAT- 2021/05/22 06:00
MHDA- 2021/12/22 06:00
PMCR- 2021/05/20
CRDT- 2021/05/21 05:34
PHST- 2021/01/30 00:00 [received]
PHST- 2021/05/10 00:00 [accepted]
PHST- 2021/05/21 05:34 [entrez]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/12/22 06:00 [medline]
PHST- 2021/05/20 00:00 [pmc-release]
AID - 10.1186/s12872-021-02057-8 [pii]
AID - 2057 [pii]
AID - 10.1186/s12872-021-02057-8 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2021 May 20;21(1):247. doi: 10.1186/s12872-021-02057-8.