PMID- 34017496
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210523
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 13
IP  - 4
DP  - 2021
TI  - Correlation between serum urea nitrogen, cystatin C, homocysteine, and chronic 
      heart failure.
PG  - 3254-3261
AB  - OBJECTIVE: To explore the correlation between uric acid (UA), cystatin C (Cys-C), 
      homocysteine (Hcy), and chronic heart failure (CHF). METHODS: 45 patients with 
      CHF were selected as the research group; 45 healthy people were selected as the 
      control group. The levels of serum UA, Cys-C and Hcy were detected. RESULTS: The 
      in The research group had much higher levels of serum UA, Cys-C and Hcy than the 
      control group (all P<0.05). The levels of above indexes also increased with an 
      increase in cardiac function classification. Patients with major adverse 
      cardiovascular events (MACE) had much higher levels of serum UA, Cys-C, and Hcy 
      than those without MACE in the research group (all P<0.05). In addition, the 
      levels of these above indexes in the research group were all positively 
      correlated with the left ventricular end diastolic diameter (LVEDD) (all P<0.05), 
      and all negatively correlated with the f left ventricular ejection fraction 
      (LVEF) (P<0.05). What is more, the levels of these above indexes in the research 
      group were all positively correlated with New York Heart Association (NYHA) grade 
      (all P<0.05). The diagnostic sensitivity of serum UA level, Cys-C level, and Hcy 
      level in joint diagnosis of CHF patients was higher than that of any single index 
      diagnosis (P<0.05), and the specificity of combined diagnosis was lower than that 
      of single index diagnosis (P<0.05). CONCLUSION: The levels of serum UA, Cys-C, 
      and Hcy in CHF patients may be used as reference indexes for clinical screening 
      of early CHF patients and could provide a certain reference for clinical 
      evaluation.
CI  - AJTR Copyright (c) 2021.
FAU - Yao, Zongqin
AU  - Yao Z
AD  - Department of Cardiology, Linyi Central Hospital Linyi, Shandong Province, China.
FAU - Li, Guangfeng
AU  - Li G
AD  - Department of Neurology, Linyi Central Hospital Linyi, Shandong Province, China.
FAU - Li, Guangcai
AU  - Li G
AD  - Department of Clinical Pharmacy, Linyi Central Hospital Linyi, Shandong Province, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210415
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC8129353
OTO - NOTNLM
OT  - Uric acid
OT  - cardiac function
OT  - chronic heart failure
OT  - correlation
OT  - cystatin C
OT  - homocysteine
COIS- None.
EDAT- 2021/05/22 06:00
MHDA- 2021/05/22 06:01
PMCR- 2021/04/15
CRDT- 2021/05/21 06:32
PHST- 2020/11/20 00:00 [received]
PHST- 2020/12/27 00:00 [accepted]
PHST- 2021/05/21 06:32 [entrez]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/05/22 06:01 [medline]
PHST- 2021/04/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2021 Apr 15;13(4):3254-3261. eCollection 2021.