PMID- 34017921
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2391-5412 (Electronic)
IS  - 2391-5412 (Linking)
VI  - 16
IP  - 1
DP  - 2021
TI  - Vitamin D deficiency and cardiovascular risk in type 2 diabetes population.
PG  - 464-474
LID - 10.1515/biol-2021-0050 [doi]
AB  - This study aims to assess vitamin D deficiency-induced dyslipidemia and 
      cardiovascular disease (CVD) risk in poor glycemic control among type 2 diabetes 
      mellitus (T2DM) patients. This study was carried out among 455 T2DM patients 
      involving poor glycemic control (n = 247) and good glycemic control (n = 208). 
      Fasting plasma glucose (FPG) and HbA(1)c were measured to assess glycemic 
      control. Cardiac risk ratio, atherogenic index plasma, and atherogenic 
      coefficient were calculated to assess and compare the CVD risk in different 
      groups. Patients with poor control had a significantly higher level of total 
      cholesterol (TC), triglyceride (TG), and non-high-density lipoprotein lipase 
      cholesterol (non-HDL-C), atherogenic variables, and lower level of high-density 
      lipoprotein lipase cholesterol (HDL-C) as compared to patients with good glycemic 
      control. We also observed significant negative correlation of vitamin D with 
      lipid markers and atherogenic variables in poor glycemic control diabetic 
      population. The serum vitamin D levels were inversely associated with HbA(1)c, 
      FPG, TG, TC, and non-HDL-C. Furthermore, hypercholesterolemia, 
      hypertriglyceridemia, and elevated non-HDL-C were the independent risks in 
      hypovitaminosis D population. Vitamin D deficiency in poor glycemic control is 
      likely to develop dyslipidemia as compared to vitamin D insufficient and 
      sufficient groups. Thus, vitamin D supplementation and an increase in exposure to 
      sunlight may reduce the risk of cardiovascular complications in diabetes.
CI  - (c) 2021 Sushant Pokhrel et al., published by De Gruyter.
FAU - Pokhrel, Sushant
AU  - Pokhrel S
AD  - Department of Laboratory Medicine, Manmohan Memorial Institute of Health 
      Sciences, P. O. Box No. 15201, Kathmandu, Nepal.
AD  - Department of Genetics, National academy of Medical Sciences, Bir Hospital, 
      Kathmandu, Nepal.
FAU - Giri, Nisha
AU  - Giri N
AD  - Department of Laboratory Medicine, Manmohan Memorial Institute of Health 
      Sciences, P. O. Box No. 15201, Kathmandu, Nepal.
FAU - Pokhrel, Rakesh
AU  - Pokhrel R
AD  - Department of Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, 
      Kathmandu, Nepal.
FAU - Pardhe, Bashu Dev
AU  - Pardhe BD
AD  - Department of Life Science and Biochemical Engineering, Sun Moon University, 
      Asan-Si, Chumgnam, South Korea.
FAU - Lamichhane, Anit
AU  - Lamichhane A
AD  - Department of Laboratory Medicine, Manmohan Memorial Institute of Health 
      Sciences, P. O. Box No. 15201, Kathmandu, Nepal.
FAU - Chaudhary, Abhisek
AU  - Chaudhary A
AD  - Department of Clinical Pathology, Modern Diagnostic Laboratory and Research 
      Center, Kathmandu, Nepal.
FAU - Bhatt, Mahendra Prasad
AU  - Bhatt MP
AD  - Department of Laboratory Medicine, Manmohan Memorial Institute of Health 
      Sciences, P. O. Box No. 15201, Kathmandu, Nepal.
LA  - eng
PT  - Journal Article
DEP - 20210510
PL  - Poland
TA  - Open Life Sci
JT  - Open life sciences
JID - 101669614
PMC - PMC8114957
OTO - NOTNLM
OT  - dyslipidemia
OT  - glycemic control
OT  - type 2 diabetes mellitus
OT  - vitamin D
COIS- Conflict of interest: The authors state no conflict of interest.
EDAT- 2021/05/22 06:00
MHDA- 2021/05/22 06:01
PMCR- 2021/05/10
CRDT- 2021/05/21 06:35
PHST- 2021/02/12 00:00 [received]
PHST- 2021/04/09 00:00 [revised]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/05/21 06:35 [entrez]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/05/22 06:01 [medline]
PHST- 2021/05/10 00:00 [pmc-release]
AID - biol-2021-0050 [pii]
AID - 10.1515/biol-2021-0050 [doi]
PST - epublish
SO  - Open Life Sci. 2021 May 10;16(1):464-474. doi: 10.1515/biol-2021-0050. 
      eCollection 2021.