PMID- 34017933
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 5
IP  - 6
DP  - 2021 Jun 1
TI  - Clinical Course of Euthyroid Subjects With Positive TSH Receptor Antibody: How 
      Often Does Graves' Disease Develop?
PG  - bvab042
LID - 10.1210/jendso/bvab042 [doi]
LID - bvab042
AB  - BACKGROUND: Thyroid stimulating hormone receptor antibody (TRAb) is detected in 
      the serum of patients with Graves' disease (GD). This study aims to investigate 
      the prevalence of euthyroid individuals showing positive results for TRAb and to 
      clarify the clinical course of thyroid function and TRAb levels in these 
      subjects. OBJECTIVE: Subjects were female patients who newly visited our hospital 
      for a screening test prior to fertility treatment and showed normal thyroid 
      function and volume without nodules between 2014 and 2017. After excluding 
      subjects with a history of thyroid disease, 5,622 subjects were analyzed. 
      RESULTS: Forty-seven of the 5,622 subjects showed positive results for TRAb 
      (reference range, <2.0 IU/L) at the initial visit. Median initial TRAb was 2.9 
      IU/L (range, 2.0-14.7 IU/L) and median follow-up was 18.3 months (range, 0-66.5 
      months). Six of the 47 subjects (12.8%) developed GD and median duration until 
      development was 6.6 months (range, 1.2-13.2 months). Median TRAb values initially 
      and at diagnosis of GD for those 6 patients were 3.7 IU/L (range, 2.7-5.1 IU/L) 
      and 7.2 IU/L (range 3.6-21.4 IU/L), respectively. TRAb results turned negative 
      for 20 of the 47 subjects but remained positive despite normal thyroid function 
      in 13 of the 47 subjects. CONCLUSION: GD developed over time in 12.8% of 
      euthyroid young female patients showing positive TRAb within a median of 6.6 
      months. A positive result for TRAb itself did not mean development of GD, so 
      other factors must be essential for the pathogenesis of GD.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Endocrine Society.
FAU - Suzuki, Nami
AU  - Suzuki N
AUID- ORCID: 0000-0003-2877-6647
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Kawaguchi, Akiko
AU  - Kawaguchi A
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Yoshimura Noh, Jaeduk
AU  - Yoshimura Noh J
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Yoshimura, Ran
AU  - Yoshimura R
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Mikura, Kentaro
AU  - Mikura K
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Kinoshita, Aya
AU  - Kinoshita A
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Suzuki, Ai
AU  - Suzuki A
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Mitsumatsu, Takako
AU  - Mitsumatsu T
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Hoshiyama, Ayako
AU  - Hoshiyama A
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Fukushita, Miho
AU  - Fukushita M
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Matsumoto, Masako
AU  - Matsumoto M
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Yoshihara, Ai
AU  - Yoshihara A
AUID- ORCID: 0000-0003-1323-4722
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Watanabe, Natsuko
AU  - Watanabe N
AD  - Department of Internal medicine, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Sugino, Kiminori
AU  - Sugino K
AUID- ORCID: 0000-0002-9692-9871
AD  - Department of Surgery, Ito Hospital, Tokyo, 150-0001, Japan.
FAU - Ito, Koichi
AU  - Ito K
AD  - Department of Surgery, Ito Hospital, Tokyo, 150-0001, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210315
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
PMC - PMC8122366
OTO - NOTNLM
OT  - TSH receptor antibody
OT  - thyroid function
EDAT- 2021/05/22 06:00
MHDA- 2021/05/22 06:01
PMCR- 2021/03/15
CRDT- 2021/05/21 06:35
PHST- 2021/02/01 00:00 [received]
PHST- 2021/05/21 06:35 [entrez]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/05/22 06:01 [medline]
PHST- 2021/03/15 00:00 [pmc-release]
AID - bvab042 [pii]
AID - 10.1210/jendso/bvab042 [doi]
PST - epublish
SO  - J Endocr Soc. 2021 Mar 15;5(6):bvab042. doi: 10.1210/jendso/bvab042. eCollection 
      2021 Jun 1.