PMID- 34018633
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 48
IP  - 9
DP  - 2021 Sep
TI  - A pediatric case of Stevens-Johnson syndrome with acute liver failure, resulting 
      in liver transplantation.
PG  - 1423-1427
LID - 10.1111/1346-8138.15963 [doi]
AB  - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal 
      adverse skin reactions characterized by high fever, epidermal detachment, and 
      mucositis. It is well known that SJS/TEN occasionally affects various organs, 
      leading to permanent damage and death in some patients. Although acute liver 
      dysfunction is a relatively common complication of SJS/TEN, severe acute liver 
      dysfunction requiring liver transplantation is rare. We present the case of a 
      14-year-old girl with SJS complicated by severe and rapidly progressive liver 
      dysfunction, specifically, acute liver failure (ALF) requiring liver 
      transplantation. A lymphocyte transformation test showed positive results for 
      acetaminophen and cefdinir. Furthermore, human leukocyte antigen (HLA) genotyping 
      revealed the presence of the HLA-A*02:06 genotype, which is reported to be 
      strongly associated with acetaminophen-related SJS/TEN with severe ocular 
      complications. These results suggested that our patient may have presented with 
      acetaminophen-induced SJS complicated by ALF, but no ocular complications. This 
      is the first report of a pediatric patient with SJS who required liver 
      transplantation. In rare instances, severe liver dysfunction requiring liver 
      transplantation should be considered as a possible complication of SJS/TEN.
CI  - (c) 2021 Japanese Dermatological Association.
FAU - Totsuka, Michiru
AU  - Totsuka M
AUID- ORCID: 0000-0002-1478-2897
AD  - Department of Dermatology, Yokohama City University School of Medicine, Yokohama, 
      Japan.
FAU - Watanabe, Tomoya
AU  - Watanabe T
AUID- ORCID: 0000-0002-6654-6175
AD  - Department of Dermatology, Yokohama City University School of Medicine, Yokohama, 
      Japan.
FAU - Takamura, Naoko
AU  - Takamura N
AD  - Department of Dermatology, Yokohama City University School of Medicine, Yokohama, 
      Japan.
FAU - Watanabe, Yuko
AU  - Watanabe Y
AUID- ORCID: 0000-0002-0598-856X
AD  - Department of Dermatology, Yokohama City University School of Medicine, Yokohama, 
      Japan.
FAU - Kumamoto, Takafumi
AU  - Kumamoto T
AD  - Department of Gastroenterological Surgery, Yokohama City University School of 
      Medicine, Yokohama, Japan.
FAU - Honda, Yasushi
AU  - Honda Y
AD  - Department of Gastroenterology and Hepatology, Yokohama City University School of 
      Medicine, Yokohama, Japan.
FAU - Yoneda, Masato
AU  - Yoneda M
AD  - International Clinical Center for Liver Diseases, Yokohama City University, 
      Yokohama, Japan.
FAU - Saito, Satoru
AU  - Saito S
AD  - International Clinical Center for Liver Diseases, Yokohama City University, 
      Yokohama, Japan.
FAU - Yamanaka, Shoji
AU  - Yamanaka S
AD  - Department of Pathology, Yokohama City University School of Medicine, Yokohama, 
      Japan.
FAU - Aihara, Michiko
AU  - Aihara M
AD  - Department of Dermatology, Yokohama City University School of Medicine, Yokohama, 
      Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210521
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/adverse effects
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - *Liver Failure, Acute/etiology/surgery
MH  - *Liver Transplantation/adverse effects
MH  - Skin
MH  - *Stevens-Johnson Syndrome/complications/diagnosis
OTO - NOTNLM
OT  - Stevens-Johnson syndrome
OT  - acetaminophen
OT  - liver dysfunction
OT  - liver transplantation
OT  - toxic epidermal necrolysis
EDAT- 2021/05/22 06:00
MHDA- 2021/09/04 06:00
CRDT- 2021/05/21 08:53
PHST- 2021/04/22 00:00 [revised]
PHST- 2021/02/16 00:00 [received]
PHST- 2021/04/23 00:00 [accepted]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
PHST- 2021/05/21 08:53 [entrez]
AID - 10.1111/1346-8138.15963 [doi]
PST - ppublish
SO  - J Dermatol. 2021 Sep;48(9):1423-1427. doi: 10.1111/1346-8138.15963. Epub 2021 May 
      21.