PMID- 34018995
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20240119
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 134
IP  - 10
DP  - 2021 Apr 14
TI  - Association between follistatin-related protein 1 and the functional status of 
      patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
PG  - 1168-1174
LID - 10.1097/CM9.0000000000001454 [doi]
AB  - BACKGROUND: Follistatin-like 1 (FSTL1) plays both pro-inflammatory and 
      anti-inflammatory roles in the inflammatory processes. We investigated whether 
      serum FSTL1 could predict the current anti-neutrophil cytoplasmic 
      antibody-associated vasculitis (AAV)-specific indices. METHODS: We randomly 
      selected 74 patients with AAV from a prospective and observational cohort of 
      Korean patients with AAV. Clinical and laboratory data and AAV-specific indices 
      were recorded. FSTL1 concentration was determined using the stored sera. The 
      lowest tertile of the short-form 36-item health survey (SF-36) was defined as the 
      current low SF-36. The cutoffs of serum FSTL1 for the current low SF-36 physical 
      component summary (PCS) and SF-36 mental component summary (MCS) were 
      extrapolated by the receiver operator characteristic curve. RESULTS: The median 
      age was 62.5 years (55.4% were women). Serum FSTL1 was significantly correlated 
      with SF-36 PCS (r =  - 0.374), SF-36 MCS (r = -0.377), and C-reactive protein 
      (CRP) (r = 0.307), but not with Birmingham vasculitis activity score (BVAS). In 
      the multivariable linear regression analyses, BVAS, CRP, and serum FSTL1 were 
      independently associated with the current SF-36 PCS (beta = -0.255, beta = -0.430, and 
      beta = -0.266, respectively) and the current SF-36 MCS (beta = -0.234, beta =-0.229, and 
      beta = -0.296, respectively). Patients with serum FSTL1 >/=779.8 pg/mL and those with 
      serum FSTL1 >/=841.6 pg/mL exhibited a significantly higher risk of having the 
      current low SF-36 PCS and SF-36 MCS than those without (relative risk 7.583 and 
      6.200, respectively). CONCLUSION: Serum FSTL1 could predict the current 
      functional status in AAV patients.
CI  - Copyright (c) 2021 The Chinese Medical Association, produced by Wolters Kluwer, 
      Inc. under the CC-BY-NC-ND license.
FAU - Yoon, Taejun
AU  - Yoon T
AD  - Department of Medical Science, BK21 Plus Project, Yonsei University, College of 
      Medicine, Seoul, Republic of Korea.
FAU - Ahn, Sung Soo
AU  - Ahn SS
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Pyo, Jung Yoon
AU  - Pyo JY
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Song, Jason Jungsik
AU  - Song JJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Republic of Korea.
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Republic of Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20210414
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Follistatin)
RN  - 0 (Follistatin-Related Proteins)
RN  - 158709-61-6 (FSTL1 protein, human)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MH  - Female
MH  - Follistatin
MH  - *Follistatin-Related Proteins
MH  - Functional Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Severity of Illness Index
PMC - PMC8143737
COIS- None.
EDAT- 2021/05/22 06:00
MHDA- 2021/05/26 06:00
PMCR- 2021/05/20
CRDT- 2021/05/21 12:19
PHST- 2021/05/21 12:19 [entrez]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2021/05/20 00:00 [pmc-release]
AID - 00029330-202105200-00006 [pii]
AID - CMJ-2020-3362 [pii]
AID - 10.1097/CM9.0000000000001454 [doi]
PST - epublish
SO  - Chin Med J (Engl). 2021 Apr 14;134(10):1168-1174. doi: 
      10.1097/CM9.0000000000001454.