PMID- 34019264
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1304
DP  - 2021
TI  - Interstitial Lung Disease Associated with Connective Tissue Diseases.
PG  - 73-94
LID - 10.1007/978-3-030-68748-9_5 [doi]
AB  - Pulmonary manifestations of connective tissue diseases (CTD) carry high morbidity 
      and potential mortality, and the most serious pulmonary type is interstitial lung 
      disease (ILD). Identifying and promptly intervening CTD-ILD with immune 
      suppressor therapy will change the natural course of the disease resulting in 
      survival improvement. Compared to idiopathic pulmonary fibrosis, the most common 
      presentation of idiopathic interstitial pneumonia (IIP), CTD-ILD carries a better 
      prognosis due to the response to immune suppressor therapy. Nonspecific 
      interstitial pneumonia (NSIP) is the most common type of CTD-ILD that is 
      different from the fibrotic classical presentation of IPF, known as usual 
      interstitial pneumonia (UIP). An exception is rheumatoid arthritis that presents 
      more frequently with UIP type. Occasionally, IPF may not have typical 
      radiographic features of UIP, and a full assessment to differentiate IPF from 
      CTD-ILD is necessary, including the intervention of a multidisciplinary team and 
      the histopathology. Interstitial pneumonia with autoimmune features (IPAF) shows 
      promising advantages to identify patients with ILD who have some features of a 
      CTD without a defined autoimmune disease and who may benefit from immune 
      suppressors. A composition of clinical, serological, and morphologic features in 
      patients presenting with ILD will fulfill criteria for IPAF. In summary, the 
      early recognition and treatment of CTD-ILD, differentiation from IPF-UIP, and 
      identification of patients with IPAF fulfill the assessment by the clinician for 
      an optimal care.
FAU - Peredo, Ruben A
AU  - Peredo RA
AD  - Division of Rheumatology, Department of Medicine, Albany Medical College, Albany, 
      NY, USA. peredor@amc.edu.
FAU - Mehta, Vivek
AU  - Mehta V
AD  - Rheumatology, Alaska Native Medical Center, Anchorage, AK, USA.
FAU - Beegle, Scott
AU  - Beegle S
AD  - Division of Pulmonary & Critical Care Medicine, Albany Medical College, Albany, 
      NY, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - *Connective Tissue Diseases/complications/diagnosis
MH  - Humans
MH  - *Idiopathic Pulmonary Fibrosis/complications/diagnosis
MH  - Lung
MH  - *Lung Diseases, Interstitial/complications/diagnosis
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Connective tissue disease
OT  - Interstitial lung disease
OT  - Interstitial pneumonia with autoimmune features
EDAT- 2021/05/22 06:00
MHDA- 2021/05/26 06:00
CRDT- 2021/05/21 12:30
PHST- 2021/05/21 12:30 [entrez]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
AID - 10.1007/978-3-030-68748-9_5 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2021;1304:73-94. doi: 10.1007/978-3-030-68748-9_5.