PMID- 34020228
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 235
DP  - 2021 Jun
TI  - Association of persistent organic pollutants with sensorimotor neuropathy in 
      participants with and without diabetes or prediabetes: Results from the 
      population-based KORA FF4 study.
PG  - 113752
LID - S1438-4639(21)00067-5 [pii]
LID - 10.1016/j.ijheh.2021.113752 [doi]
AB  - BACKGROUND: Concentrations of persistent organic pollutants (POPs) have been 
      associated with an increased type 2 diabetes (T2D) risk. It remains unclear 
      whether POPs are also associated with the risk of diabetes complications 
      including neuropathy and evidence on this topic is scarce. We aimed to 
      investigate the hypothesis that low-dose background concentrations of POPs were 
      positively associated with distal sensorimotor polyneuropathy (DSPN). METHODS: 
      This cross-sectional study was based on data from the second follow-up (FF4, 
      2013-2014, N = 2279) of the population-based KORA S4 study (Augsburg, Germany). 
      The study sample consisted of 200 participants, including four groups of 50 
      persons each with known T2D, prediabetes, newly diagnosed diabetes, and normal 
      glucose tolerance (NGT) based on an oral glucose tolerance test. We analyzed the 
      association of six most abundant serum concentrations of POPs, including 
      polychlorinated biphenyls (PCBs) as well as organochlorine (OC) pesticides, with 
      DSPN by multivariable logistic regression adjusted for age, sex, glycaemic 
      status, body mass index, physical activity, smoking and alcohol consumption. We 
      assessed effect modification by age, sex, glycaemic status and obesity and 
      conducted two-pollutant models to check the robustness of the estimates. RESULTS: 
      For all pollutants, the main models indicated no significant association of 
      having DSPN but pointed to rather decreased odds for DSPN. Two-pollutant models 
      supported these findings, though only the association between the combination of 
      PCB-138 and beta-hexachlorocyclohexane (beta-HCH) (OR: 0.59; 95% CI: 0.35-0.99) with 
      DSPN became significant. No effect modification was found by age, sex, glycaemic 
      status and obesity. CONCLUSION: Low-dose concentrations of POPs were not 
      associated with increased odds of having DSPN in T2D, prediabetes and NGT.
CI  - Copyright (c) 2021 Elsevier GmbH. All rights reserved.
FAU - Schwarz, Maximilian
AU  - Schwarz M
AD  - Institute for Medical Information Processing, Biometry and Epidemiology - IBE, 
      LMU Munich, Munich, Germany; Pettenkofer School of Public Health, Munich, 
      Germany; Institute of Epidemiology, Helmholtz Zentrum Munchen GmbH - German 
      Research Center for Environmental Health, Neuherberg, Germany. Electronic 
      address: maximilian.schwarz@helmholtz-muenchen.de.
FAU - Wolf, Kathrin
AU  - Wolf K
AD  - Institute of Epidemiology, Helmholtz Zentrum Munchen GmbH - German Research 
      Center for Environmental Health, Neuherberg, Germany.
FAU - Schneider, Alexandra
AU  - Schneider A
AD  - Institute of Epidemiology, Helmholtz Zentrum Munchen GmbH - German Research 
      Center for Environmental Health, Neuherberg, Germany.
FAU - Schramm, Karl-Werner
AU  - Schramm KW
AD  - Molecular EXposomics, Helmholtz Zentrum Munchen GmbH - German Research Center for 
      Environmental Health, Neuherberg, Germany; Research Department Biosciences, 
      Campus Life Science Weihenstephan, Technical University Munich, Freising, 
      Germany.
FAU - Bongaerts, Brenda
AU  - Bongaerts B
AD  - Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center 
      for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; German 
      Center for Diabetes Research (DZD), Neuherberg, Germany.
FAU - Henkelmann, Bernhard
AU  - Henkelmann B
AD  - Molecular EXposomics, Helmholtz Zentrum Munchen GmbH - German Research Center for 
      Environmental Health, Neuherberg, Germany.
FAU - Herder, Christian
AU  - Herder C
AD  - Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; German 
      Center for Diabetes Research (DZD), Neuherberg, Germany; Division of 
      Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, 
      Dusseldorf, Germany.
FAU - Roden, Michael
AU  - Roden M
AD  - Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; German 
      Center for Diabetes Research (DZD), Neuherberg, Germany; Division of 
      Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, 
      Dusseldorf, Germany.
FAU - Peters, Annette
AU  - Peters A
AD  - Institute for Medical Information Processing, Biometry and Epidemiology - IBE, 
      LMU Munich, Munich, Germany; Institute of Epidemiology, Helmholtz Zentrum Munchen 
      GmbH - German Research Center for Environmental Health, Neuherberg, Germany.
FAU - Ziegler, Dan
AU  - Ziegler D
AD  - Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; German 
      Center for Diabetes Research (DZD), Neuherberg, Germany; Division of 
      Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, 
      Dusseldorf, Germany.
FAU - Rathmann, Wolfgang
AU  - Rathmann W
AD  - Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center 
      for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; German 
      Center for Diabetes Research (DZD), Neuherberg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210519
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Environmental Pollutants
MH  - Humans
MH  - *Hydrocarbons, Chlorinated
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls
MH  - *Prediabetic State/epidemiology
OTO - NOTNLM
OT  - Diabetes
OT  - KORA
OT  - Peripheral polyneuropathy
OT  - Persistent organic pollutant
OT  - Polyneuropathy
EDAT- 2021/05/22 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/05/21 20:24
PHST- 2020/11/13 00:00 [received]
PHST- 2021/04/01 00:00 [revised]
PHST- 2021/04/05 00:00 [accepted]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/05/21 20:24 [entrez]
AID - S1438-4639(21)00067-5 [pii]
AID - 10.1016/j.ijheh.2021.113752 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2021 Jun;235:113752. doi: 10.1016/j.ijheh.2021.113752. 
      Epub 2021 May 19.