PMID- 34020371
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210625
IS  - 1936-5233 (Print)
IS  - 1936-5233 (Electronic)
IS  - 1936-5233 (Linking)
VI  - 14
IP  - 8
DP  - 2021 Aug
TI  - Effect of low-dose total-body radiotherapy on immune microenvironment.
PG  - 101118
LID - S1936-5233(21)00110-8 [pii]
LID - 10.1016/j.tranon.2021.101118 [doi]
LID - 101118
AB  - The history of low-dose total-body irradiation (LTBI) as a means of radiotherapy 
      for treating malignant tumors can be traced back to the 1920s. Despite this very 
      low total dose, LTBI can induce long-term remissions. Tumor cells are known to 
      change and maintain their own survival and development conditions through 
      autocrine and paracrine signaling. LTBI can change the tumor microenvironment, 
      enhance the infiltration of activated T cells, and trigger inflammatory 
      processes. LTBI-mediated immune response can exert systemic long-term anti-tumor 
      effects, and can induce tumor regression at the primary site and metastatic 
      sites. With a continuous improvement in the anti-tumor immune microenvironment in 
      the field of tumor therapy, LTBI provides more choices to comprehensively treat 
      of tumors. The present study aimed to explore the experimental research mechanism 
      of LTBI and immune microenvironment, and discuss the difficulties and development 
      prospects of applying LTBI to tumor treatment.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Chen, Zhuo
AU  - Chen Z
AD  - Department of Oncology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan Province, China.
FAU - Wu, Zhouxue
AU  - Wu Z
AD  - Department of Oncology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan Province, China.
FAU - Muluh, Tobias Achu
AU  - Muluh TA
AD  - Department of Oncology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan Province, China.
FAU - Fu, Shaozhi
AU  - Fu S
AD  - Department of Oncology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan Province, China.
FAU - Wu, Jingbo
AU  - Wu J
AD  - Department of Oncology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan Province, China; Key Laboratory of Nuclear Medicine and Molecular 
      Imaging, Sichuan Province, China. Electronic address: wjb6147@swmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210518
PL  - United States
TA  - Transl Oncol
JT  - Translational oncology
JID - 101472619
PMC - PMC8142085
OTO - NOTNLM
OT  - Immune microenvironment
OT  - Low dose total-body irradiation
OT  - New tumor comprehensive treatment
OT  - Radiotherapy
OT  - Tumor
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/05/22 06:00
MHDA- 2021/05/22 06:01
PMCR- 2021/05/18
CRDT- 2021/05/21 20:30
PHST- 2021/02/20 00:00 [received]
PHST- 2021/04/23 00:00 [revised]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/05/22 06:00 [pubmed]
PHST- 2021/05/22 06:01 [medline]
PHST- 2021/05/21 20:30 [entrez]
PHST- 2021/05/18 00:00 [pmc-release]
AID - S1936-5233(21)00110-8 [pii]
AID - 101118 [pii]
AID - 10.1016/j.tranon.2021.101118 [doi]
PST - ppublish
SO  - Transl Oncol. 2021 Aug;14(8):101118. doi: 10.1016/j.tranon.2021.101118. Epub 2021 
      May 18.