PMID- 34022473
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 139
DP  - 2021 Jul
TI  - Accelerated aging signatures in subjects with schizophrenia and their unaffected 
      siblings.
PG  - 30-37
LID - S0022-3956(21)00256-9 [pii]
LID - 10.1016/j.jpsychires.2021.04.029 [doi]
AB  - Schizophrenia (SZ) is a chronic debilitating disease. Subjects with SZ have 
      significant shorter life expectancy. Growing evidence suggests that a process of 
      pathological accelerated aging occurs in SZ, leading to early development of 
      severe clinical diseases and worse morbimortality. Furthermore, unaffected 
      relatives can share certain endophenotypes with subjects with SZ. We aim to 
      characterize accelerated aging as a possible endophenotype of schizophrenia by 
      using a machine learning (ML) model of peripheral biomarkers to accurately 
      differentiate subjects with SZ (n = 35), their unaffected siblings (SB, n = 36) 
      and healthy controls (HC, n = 47). We used a random forest algorithm that 
      included biomarkers related to aging: eotaxins CCL-11 and CCL-24; the oxidative 
      stress markers thiobarbituric acid-reactive substances (TBARS), protein carbonyl 
      content (PCC), glutathione peroxidase (GPx); and telomere length (TL). The ML 
      algorithm of biomarkers was able to distinguish individuals with SZ from HC with 
      prediction accuracy of 79.7%, SZ from SB with 62.5% accuracy and SB from HC with 
      75.5% accuracy. These results support the hypothesis that a pathological 
      accelerated aging might occur in SZ, and this pathological aging could be an 
      endophenotype of the disease, once this profile was also observed in SB, 
      suggesting that SB might suffer from an accelerated aging in some level.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Reboucas, Diego Barreto
AU  - Reboucas DB
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de 
      Pos-Graduacao em Psiquiatria e Ciencias do Comportamento, Universidade Federal do 
      Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Sartori, Juliana Mastella
AU  - Sartori JM
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de 
      Pos-Graduacao em Psiquiatria e Ciencias do Comportamento, Universidade Federal do 
      Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Librenza-Garcia, Diego
AU  - Librenza-Garcia D
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Department of 
      Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, 
      Canada.
FAU - Rabelo-da-Ponte, Francisco Diego
AU  - Rabelo-da-Ponte FD
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de 
      Pos-Graduacao em Psiquiatria e Ciencias do Comportamento, Universidade Federal do 
      Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Massuda, Raffael
AU  - Massuda R
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Departamento de 
      Psiquiatria, Universidade Federal do Parana, Curitiba, Brazil.
FAU - Czepielewski, Leticia Sanguinetti
AU  - Czepielewski LS
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pos- 
      Graduacao em Psicologia, Departamento de Psicologia do Desenvolvimento e da 
      Personalidade, Instituto de Psicologia, Universidade Federal do Rio Grande do 
      Sul, Porto Alegre, Brazil.
FAU - Passos, Ives Cavalcante
AU  - Passos IC
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de 
      Pos-Graduacao em Psiquiatria e Ciencias do Comportamento, Universidade Federal do 
      Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Gama, Clarissa Severino
AU  - Gama CS
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de 
      Pos-Graduacao em Psiquiatria e Ciencias do Comportamento, Universidade Federal do 
      Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: cgama@hcpa.edu.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210430
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Aging
MH  - Endophenotypes
MH  - Humans
MH  - Protein Carbonylation
MH  - *Schizophrenia/genetics
MH  - Siblings
OTO - NOTNLM
OT  - Accelerated aging
OT  - Biomarkers
OT  - Endophenotypes
OT  - Machine learning
OT  - Schizophrenia
OT  - Siblings
EDAT- 2021/05/23 06:00
MHDA- 2021/07/06 06:00
CRDT- 2021/05/22 20:14
PHST- 2020/11/23 00:00 [received]
PHST- 2021/04/10 00:00 [revised]
PHST- 2021/04/25 00:00 [accepted]
PHST- 2021/05/23 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2021/05/22 20:14 [entrez]
AID - S0022-3956(21)00256-9 [pii]
AID - 10.1016/j.jpsychires.2021.04.029 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2021 Jul;139:30-37. doi: 10.1016/j.jpsychires.2021.04.029. Epub 
      2021 Apr 30.