PMID- 3402302
OWN - NLM
STAT- MEDLINE
DCOM- 19880912
LR  - 20221207
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 11
IP  - 6
DP  - 1988 Jun
TI  - Early detection of neurological involvement in IDDM and NIDDM. Multimodal evoked 
      potentials versus metabolic control.
PG  - 473-80
AB  - Clarification of the extent and mechanisms of damage to the central nervous 
      system in diabetes is a frontier of current neurological research. Our aim was to 
      obtain ample electrophysiological documentation of possible neurological 
      abnormalities in both insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) 
      diabetic patients with a short duration of disease and without overt 
      complications, taking into account metabolic control. Group 1 comprised 11 IDDM 
      patients, and group 2 included 14 NIDDM patients treated with diet alone; the 
      duration of disease was less than 4 yr, and no concomitant clinical complications 
      were present. Age- and sex-matched normal subjects formed groups 3 and 4. Pattern 
      visual evoked potentials (VEP), brain stem auditory evoked potentials (BAEP), and 
      somatosensory evoked potentials (SEP; after the stimulation of both median and 
      tibial nerves) were recorded in all subjects, and metabolic control was evaluated 
      in terms of glycemia and glycosylated hemoglobin. In group 1, significant 
      abnormalities were found in the latency values of VEP, median SEP, and tibial SEP 
      compared with control subjects. Similar latency abnormalities were shown in group 
      2 for VEP, median SEP, and tibial SEP values and for wave I latency of BAEP. 
      Glycosylated hemoglobin values were correlated with BAEP and SEP abnormalities in 
      many patients in both groups. Furthermore, in group 2, glycemic values correlated 
      with SEP abnormalities. We therefore conclude that neurophysiological 
      abnormalities are present at different levels in IDDM and NIDDM patients only a 
      few years after clinical diagnosis and before the appearance of overt 
      complications, and these abnormalities seem to be correlated with metabolic 
      control status.
FAU - Pozzessere, G
AU  - Pozzessere G
AD  - Istituto di Clinica delle Malattie Nervose e Mentali, University La Sapienza, 
      Rome, Italy.
FAU - Rizzo, P A
AU  - Rizzo PA
FAU - Valle, E
AU  - Valle E
FAU - Mollica, M A
AU  - Mollica MA
FAU - Meccia, A
AU  - Meccia A
FAU - Morano, S
AU  - Morano S
FAU - Di Mario, U
AU  - Di Mario U
FAU - Andreani, D
AU  - Andreani D
FAU - Morocutti, C
AU  - Morocutti C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Brain Stem/physiopathology
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diabetic Neuropathies/*diagnosis/physiopathology/prevention & control
MH  - *Evoked Potentials, Auditory
MH  - *Evoked Potentials, Somatosensory
MH  - *Evoked Potentials, Visual
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
EDAT- 1988/06/01 00:00
MHDA- 1988/06/01 00:01
CRDT- 1988/06/01 00:00
PHST- 1988/06/01 00:00 [pubmed]
PHST- 1988/06/01 00:01 [medline]
PHST- 1988/06/01 00:00 [entrez]
AID - 10.2337/diacare.11.6.473 [doi]
PST - ppublish
SO  - Diabetes Care. 1988 Jun;11(6):473-80. doi: 10.2337/diacare.11.6.473.