PMID- 3402315 OWN - NLM STAT- MEDLINE DCOM- 19880915 LR - 20190903 IS - 0012-4486 (Print) IS - 0012-4486 (Linking) VI - 68 IP - 3-4 DP - 1988 Mar-Apr TI - Electrophysiological discrimination between retinal and optic nerve disorders. PG - 247-55 AB - In this study we show how the Pattern ERG (PERG) can be used to distinguish between optic nerve and retinal disease. Records from eyes with RBN and delayed visual evoked responses are compared with those recorded from the normal fellow eyes. In optic nerve disease there is a selective reduction of the later negative component of the PERG. PERGs were also recorded from patients with mild diabetic retinopathy. These were divided into three groups on the basis of the delay in their Visual Evoked Potential (VEP). The amplitude of both positive and negative components of the PERG fall with increasing severity of the disease thus showing that the abnormally long delay in VEP found in some cases is due to retinal disease rather than optic nerve disease. FAU - Ryan, S AU - Ryan S AD - Department of Clinical Ophthalmology, Moorfields Eye Hospital, London, UK. FAU - Arden, G B AU - Arden GB LA - eng GR - 1 RO1 EY05 98401A1/EY/NEI NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - Netherlands TA - Doc Ophthalmol JT - Documenta ophthalmologica. Advances in ophthalmology JID - 0370667 SB - IM MH - Adolescent MH - Adult MH - Diabetic Retinopathy/diagnosis MH - Diagnosis, Differential MH - *Evoked Potentials, Visual MH - Humans MH - Middle Aged MH - Neuritis/diagnosis MH - Optic Nerve Diseases/*diagnosis MH - Retinal Diseases/*diagnosis MH - Time Factors EDAT- 1988/03/01 00:00 MHDA- 1988/03/01 00:01 CRDT- 1988/03/01 00:00 PHST- 1988/03/01 00:00 [pubmed] PHST- 1988/03/01 00:01 [medline] PHST- 1988/03/01 00:00 [entrez] AID - 10.1007/BF00156431 [doi] PST - ppublish SO - Doc Ophthalmol. 1988 Mar-Apr;68(3-4):247-55. doi: 10.1007/BF00156431.