PMID- 34023404
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 757
DP  - 2021 Jul 13
TI  - Cerebrospinal fluid levels of oxidative stress measured using diacron-reactive 
      oxygen metabolites and biological antioxidant potential in patients with 
      Parkinson's disease and progressive supranuclear palsy.
PG  - 135975
LID - S0304-3940(21)00353-0 [pii]
LID - 10.1016/j.neulet.2021.135975 [doi]
AB  - Parkinson's disease (PD) is a progressive neurodegenerative disorder 
      characterized by motor and non-motor symptoms. Because no curative therapy is 
      available for PD, elucidation of its pathophysiology is important to establish 
      more effective treatments. Oxidative stress (OS) has gained attention and been 
      investigated as one of the candidates involved in the pathogenesis of PD. This 
      study aimed to evaluate OS in the cerebrospinal fluid (CSF) of patients with PD 
      and progressive supranuclear palsy (PSP) using diacron-reactive oxygen 
      metabolites (d-ROMs) and biological antioxidant potential (BAP) tests, which can 
      easily assess OS in liquid samples. Results were compared to the clinical 
      background of patients and with those of the normal control (NC) group. CSF 
      samples were obtained from 69 patients with PD, 14 patients with PSP, and 22 
      individuals in the NC group. OS levels and antioxidant capacity were measured 
      using d-ROMs and BAP tests, respectively. CSF d-ROM levels were extremely low 
      (<10 U.CARR) in all 3 groups than the plasma d-ROM levels. Antioxidant capacity 
      was significantly higher in patients with PSP (1074 +/- 79 muM) than in patients 
      with PD (918 +/- 350 muM) (p = 0.019). In the PD group, antioxidant capacity was 
      significantly lower in patients with tremor (858 +/- 269 muM) than in those without 
      tremor (1132 +/- 505 muM) (p = 0.004). Our study suggests that the CSF level of OS 
      is under homeostatic control of antioxidative mechanisms in healthy individuals 
      as well as those with neurodegenerative diseases, and increased antioxidant 
      capacity can indicate the CSF level of OS. The lower CSF level of OS in the 
      tremor dominant subtype of PD may be the reason for the benign clinical course.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Takahashi, Kenta
AU  - Takahashi K
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, 2-1-1 Idai-dori, Yahaba-cho, Shiwa-gun, Iwate 
      028-3694, Japan. Electronic address: kentat@iwate-med.ac.jp.
FAU - Iwaoka, Kazuhiro
AU  - Iwaoka K
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, 2-1-1 Idai-dori, Yahaba-cho, Shiwa-gun, Iwate 
      028-3694, Japan. Electronic address: kiwaoka@iwate-med.ac.jp.
FAU - Takahashi, Kai
AU  - Takahashi K
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, 2-1-1 Idai-dori, Yahaba-cho, Shiwa-gun, Iwate 
      028-3694, Japan. Electronic address: sea.t.0926@gmail.com.
FAU - Suzuki, Yoshio
AU  - Suzuki Y
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, 2-1-1 Idai-dori, Yahaba-cho, Shiwa-gun, Iwate 
      028-3694, Japan. Electronic address: 345def@gmail.com.
FAU - Taguchi, Keita
AU  - Taguchi K
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, 2-1-1 Idai-dori, Yahaba-cho, Shiwa-gun, Iwate 
      028-3694, Japan. Electronic address: k.t.dwkisr415@gmail.com.
FAU - Yamahara, Kanako
AU  - Yamahara K
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, 2-1-1 Idai-dori, Yahaba-cho, Shiwa-gun, Iwate 
      028-3694, Japan. Electronic address: kkonno@iwate-med.ac.jp.
FAU - Maeda, Tetsuya
AU  - Maeda T
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, 2-1-1 Idai-dori, Yahaba-cho, Shiwa-gun, Iwate 
      028-3694, Japan. Electronic address: maeda@iwate-med.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210521
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/cerebrospinal fluid/chemistry/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Oxygen/chemistry/metabolism
MH  - Parkinson Disease/cerebrospinal fluid/*diagnosis
MH  - Reactive Oxygen Species/chemistry/metabolism
MH  - Supranuclear Palsy, Progressive/cerebrospinal fluid/*diagnosis
OTO - NOTNLM
OT  - Antioxidant
OT  - BAP
OT  - Oxidative stress
OT  - Parkinson's disease
OT  - d-ROM
EDAT- 2021/05/24 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/05/23 20:39
PHST- 2021/02/08 00:00 [received]
PHST- 2021/05/17 00:00 [revised]
PHST- 2021/05/17 00:00 [accepted]
PHST- 2021/05/24 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/23 20:39 [entrez]
AID - S0304-3940(21)00353-0 [pii]
AID - 10.1016/j.neulet.2021.135975 [doi]
PST - ppublish
SO  - Neurosci Lett. 2021 Jul 13;757:135975. doi: 10.1016/j.neulet.2021.135975. Epub 
      2021 May 21.