PMID- 34023574
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20211004
IS  - 1873-5967 (Electronic)
IS  - 1386-6532 (Linking)
VI  - 140
DP  - 2021 Jul
TI  - Subclinical CMV viremia is associated with increased nosocomial infections and 
      prolonged hospitalization in patients with systemic autoimmune diseases.
PG  - 104849
LID - S1386-6532(21)00116-5 [pii]
LID - 10.1016/j.jcv.2021.104849 [doi]
AB  - OBJECTIVE: Subclinical cytomegalovirus (CMV) viremia has been associated with 
      other infections, prolonged hospitalization, and mortality in select 
      immunosuppressed populations. We examined the incidence and outcomes of 
      subclinical CMV viremia in hospitalized patients with systemic autoimmune 
      diseases (AD) [systemic lupus erythematosus (SLE) or anti-neutrophil cytoplasmic 
      antibody-associated vasculitis (AAV)] using a highly sensitive CMV assay. 
      METHODS: Prospectively collected samples were obtained from AD hospitalized 
      patients at study entry with a second sample collected 1 week later or at 
      hospital discharge. Controls included age- and gender- matched inpatients without 
      AD and outpatients with AD. All samples were tested in batch using the Abbott 
      RealTime CMV for investigational use assay (RT assay), with a LLOD (LLOQ) at 21 
      IU/mL (32 IU/mL). RESULTS: Twenty-three inpatients (10 SLE, 8 AAV, 5 controls), 
      and 31 outpatient controls were recruited. Subclinical CMV viremia was found in 
      61% (11/18) of inpatient AD subjects, 3% (1/31) of outpatient AD subjects, and in 
      none of the five inpatient controls (p < 0.001). CMV viremia was associated with 
      increased median length of ICU stay (13 vs. 4 days, p = 0.033), hospital stay (17 
      vs. 9 days, p = 0.014) and increased nosocomial infections (7 vs. 1, p = 0.007). 
      CMV viremia was not associated with overall severity of illness nor with 
      disease-specific activity or damage. CONCLUSION: Over one-half of hospitalized AD 
      patients in our cohort had detectable CMV viremia, which was associated with 
      increased length of hospital stay and nosocomial infections. These data suggest 
      that further study of the immunomodulatory effects of subclinical CMV viremia in 
      AD is warranted.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Maksimowicz-McKinnon, Kathleen
AU  - Maksimowicz-McKinnon K
AD  - Medicine, Wayne State University, Henry Ford Hospital, 3031 W. Grand Blvd. Suite 
      800, Detroit, MI, USA. Electronic address: kmckinn2@hfhs.org.
FAU - Zhou, Junying
AU  - Zhou J
AD  - Henry Ford Hospital, 2799 W. Grand Blvd, Detroit, MI, USA. Electronic address: 
      jzhou1@hfhs.org.
FAU - Hudy, Jenna
AU  - Hudy J
AD  - Henry Ford Hospital, 3031 W. Grand Blvd. Suite 800, Detroit, MI, USA. Electronic 
      address: jhudy1@hfhs.org.
FAU - Hegab, Sara
AU  - Hegab S
AD  - Henry Ford Hospital, 2799 W. Grand Blvd, Detroit, MI, USA. Electronic address: 
      shegab1@hfhs.org.
FAU - McKinnon, John E
AU  - McKinnon JE
AD  - Medicine, Wayne State University, Henry Ford Hospital, 2799 W. Grand Blvd, 
      Detroit, MI, USA. Electronic address: jmckinn3@hfhs.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210505
PL  - Netherlands
TA  - J Clin Virol
JT  - Journal of clinical virology : the official publication of the Pan American 
      Society for Clinical Virology
JID - 9815671
SB  - IM
MH  - *Cross Infection/epidemiology
MH  - *Cytomegalovirus Infections/complications/epidemiology
MH  - Humans
MH  - Length of Stay
MH  - *Lupus Erythematosus, Systemic
MH  - Viremia/epidemiology
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - Cytomegalovirus
OT  - Infection
OT  - Subclinical CMV viremia
OT  - Systemic lupus erythematosus
EDAT- 2021/05/24 06:00
MHDA- 2021/10/05 06:00
CRDT- 2021/05/23 20:44
PHST- 2020/11/18 00:00 [received]
PHST- 2021/04/26 00:00 [revised]
PHST- 2021/04/28 00:00 [accepted]
PHST- 2021/05/24 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2021/05/23 20:44 [entrez]
AID - S1386-6532(21)00116-5 [pii]
AID - 10.1016/j.jcv.2021.104849 [doi]
PST - ppublish
SO  - J Clin Virol. 2021 Jul;140:104849. doi: 10.1016/j.jcv.2021.104849. Epub 2021 May 
      5.