PMID- 34023594 OWN - NLM STAT- MEDLINE DCOM- 20220228 LR - 20220228 IS - 1532-2238 (Electronic) IS - 1096-6374 (Linking) VI - 59 DP - 2021 Aug TI - Lacrimal gland enlargement and tear film changes in acromegaly patients: A controlled study. PG - 101397 LID - S1096-6374(21)00020-4 [pii] LID - 10.1016/j.ghir.2021.101397 [doi] AB - PURPOSE: Evaluation of the lacrimal gland volume (LGV) and its correlation with tear film functions, serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in acromegaly patients compared to a control group was aimed. METHODS: This prospective case-control study included the eyes of 38 patients with uncontrolled (UA) and 48 patients with controlled acromegaly (CA) and 44 patients with nonfunctioning pituitary adenoma. LGV of the patients was evaluated at the baseline, 3rd, and 6th-month visits with magnetic resonance imaging. Schirmer's test, tear breakup time (TBUT), and ocular surface disease index (OSDI) scores were evaluated at the same visits. Their correlation with serum IGF-1 and GH was investigated. Main outcome measure was the difference in mean LGV. RESULTS: The mean LGV of the acromegaly patients at the baseline visit (116.0 +/- 33.2 mm(3)) and the 3rd-month visit (119.5 +/- 36.4 mm(3)) was higher than the control group (65.2 +/- 22.3 mm(3) and 63.2 +/- 22.3 mm(3), respectively; p < 0.001) without any significant difference between the UA and CA patients in the LGV in three consecutive visits (p > 0.05). Among all patients, IGF-1 and GH levels showed a positive correlation with the LGV (p < 0.001; r = 0.52; r = 0.6, respectively). However, Schirmer, TBUT, and OSDI scores did not show any difference among the three groups at each visit (p > 0.05). CONCLUSION: Acromegaly patients may have larger lacrimal glands compared to the controls and this increase correlated with the increased IGF-1 and GH levels. Lacrimal gland volume may have no effect on its tear film related functions. CI - Copyright (c) 2021 Elsevier Ltd. All rights reserved. FAU - Mergen, Burak AU - Mergen B AD - University of Health Sciences, Basaksehir Cam ve Sakura City Hospital, Department of Ophthalmology, Istanbul, Turkey. Electronic address: burakmergen@gmail.com. FAU - Arici, Ceyhun AU - Arici C AD - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey. FAU - Kizilkilic, Osman AU - Kizilkilic O AD - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Radiology, Istanbul, Turkey. FAU - Tanriover, Necmettin AU - Tanriover N AD - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul, Turkey. FAU - Kadioglu, Pinar AU - Kadioglu P AD - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Endocrinology, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20210511 PL - Scotland TA - Growth Horm IGF Res JT - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JID - 9814320 RN - 0 (Biomarkers) RN - 0 (IGF1 protein, human) RN - 12629-01-5 (Human Growth Hormone) RN - 67763-96-6 (Insulin-Like Growth Factor I) SB - IM MH - Acromegaly/*physiopathology MH - Biomarkers/*blood MH - Case-Control Studies MH - Female MH - Follow-Up Studies MH - Human Growth Hormone/*blood MH - Humans MH - Insulin-Like Growth Factor I/*analysis MH - Lacrimal Apparatus/*pathology MH - Male MH - Middle Aged MH - Prognosis MH - Prospective Studies MH - Tears/*chemistry OTO - NOTNLM OT - Acromegaly OT - Growth hormone OT - IGF-1 OT - Lacrimal gland volume OT - Tear film EDAT- 2021/05/24 06:00 MHDA- 2022/03/01 06:00 CRDT- 2021/05/23 20:46 PHST- 2021/01/30 00:00 [received] PHST- 2021/05/01 00:00 [revised] PHST- 2021/05/02 00:00 [accepted] PHST- 2021/05/24 06:00 [pubmed] PHST- 2022/03/01 06:00 [medline] PHST- 2021/05/23 20:46 [entrez] AID - S1096-6374(21)00020-4 [pii] AID - 10.1016/j.ghir.2021.101397 [doi] PST - ppublish SO - Growth Horm IGF Res. 2021 Aug;59:101397. doi: 10.1016/j.ghir.2021.101397. Epub 2021 May 11.