PMID- 34023700
OWN - NLM
STAT- MEDLINE
DCOM- 20210701
LR  - 20210701
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 600
DP  - 2021 Oct 15
TI  - Non-stoichiometric cobalt sulfide nanodots enhance photothermal and chemodynamic 
      therapies against solid tumor.
PG  - 390-402
LID - S0021-9797(21)00730-X [pii]
LID - 10.1016/j.jcis.2021.05.058 [doi]
AB  - Photodynamic therapy (PDT) mainly relies on reactive oxygen species generated by 
      light- activated photosensitizers and oxygen to kill tumor cells. However, a 
      critical limitation of the current PDT is that it is less effective in solid 
      tumors where the microenvironment is hypoxic, and, therefore, repeated treatment 
      is required. Here, non-stoichiometric Co(2.19)S(4) nanodots (NDs), which can be 
      rapidly degraded to cobalt (Co(2+)) and sulfur (S(2-)) ions, were developed to 
      enhance tumor photothermal therapy (PTT) and chemodynamic therapy (CDT) via the 
      capture of copper (Cu(2+)) ions (starvation therapy) in the hypoxic tumor 
      microenvironment under near-infrared irradiation. Co(2.19)S(4) NDs with excellent 
      photothermal conversion efficiency (n = 52%) can be used for PTT, and the Co(2+) 
      ions produced by their degradation can catalyze the endogenous hydrogen peroxide 
      of tumor cells to produce highly toxic hydroxyl radicals to achieve tumor CDT. 
      The mechanism of starvation therapy was explored using western blotting, and the 
      results indicated that blocking the uptake of Cu(2+) ions could restrain the 
      growth and proliferation of tumors by inhibiting the BRAF/mitogen-activated 
      extracellular signal regulated kinase (MEK)/extracellular regulated protein 
      kinases (ERK) signaling pathway. Our work highlights the great potential of 
      Co(2.19)S(4) NDs as a theranostic agent for implementing 
      photoacoustic/photothermal imaging and starvation therapy-enhanced PTT/CDT.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Zhao, Le
AU  - Zhao L
AD  - Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, 
      College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 
      Heilongjiang 150025, China.
FAU - Yang, Qingzhu
AU  - Yang Q
AD  - College of Life Science and Agriculture Forestry, Qiqihar University, Qiqihar, 
      Heilongjiang 161006, China.
FAU - Guo, Wei
AU  - Guo W
AD  - Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, 
      College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 
      Heilongjiang 150025, China; Key Laboratory for Photonic and Electronic Bandgap 
      Materials, Ministry of Education, College of Chemistry and Chemical Engineering, 
      Harbin Normal University, Harbin, Heilongjiang 150025, China. Electronic address: 
      guowei@hrbnu.edu.cn.
FAU - Zhang, Feng
AU  - Zhang F
AD  - Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, 
      College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 
      Heilongjiang 150025, China.
FAU - Yu, Kai
AU  - Yu K
AD  - Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, 
      College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 
      Heilongjiang 150025, China.
FAU - Yang, Chunyu
AU  - Yang C
AD  - Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, 
      College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 
      Heilongjiang 150025, China. Electronic address: ycy104b@163.com.
FAU - Qu, Fengyu
AU  - Qu F
AD  - Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, 
      College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 
      Heilongjiang 150025, China. Electronic address: qufengyu@hrbnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210513
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (Photosensitizing Agents)
RN  - 3G0H8C9362 (Cobalt)
RN  - INZ5E36Y1V (cobaltous sulfide)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cobalt
MH  - Humans
MH  - *Nanoparticles
MH  - *Neoplasms/drug therapy
MH  - *Photochemotherapy
MH  - Photosensitizing Agents/therapeutic use
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Chemodynamic therapy
OT  - Hypoxic solid tumor
OT  - Photothermal therapy
OT  - Starvation therapy
OT  - Tumor microenvironment
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/05/24 06:00
MHDA- 2021/07/02 06:00
CRDT- 2021/05/23 20:51
PHST- 2021/02/22 00:00 [received]
PHST- 2021/04/18 00:00 [revised]
PHST- 2021/05/10 00:00 [accepted]
PHST- 2021/05/24 06:00 [pubmed]
PHST- 2021/07/02 06:00 [medline]
PHST- 2021/05/23 20:51 [entrez]
AID - S0021-9797(21)00730-X [pii]
AID - 10.1016/j.jcis.2021.05.058 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2021 Oct 15;600:390-402. doi: 
      10.1016/j.jcis.2021.05.058. Epub 2021 May 13.