PMID- 34024089
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210708
IS  - 2211-9132 (Print)
IS  - 2211-9140 (Electronic)
IS  - 2211-9132 (Linking)
VI  - 40
IP  - 2
DP  - 2021 May
TI  - Impact of high body mass index on allograft outcomes in kidney transplant 
      recipients with presensitization to human leukocyte antigen.
PG  - 304-316
LID - 10.23876/j.krcp.20.216 [doi]
AB  - BACKGROUND: This study aimed to investigate whether high body mass index (BMI) 
      and presensitization to human leukocyte antigen (HLA) in kidney transplant 
      recipients (KTRs) affected allograft outcomes. METHODS: From January 2010 to 
      December 2018, 1,290 kidney transplantations (KTs) were performed at the Seoul St 
      Mary's Hospital. Of these, 682 cases of ABO-compatible living donor KT patients 
      were enrolled. They were divided into four groups (low BMI-non-sensitized, high 
      BMI-non-sensitized, low BMI-sensitized, and high BMI-sensitized) according to the 
      median BMI value (22.7 kg/m2) and HLA presensitization status (anti-HLA antibody 
      mean fluorescence intensity > 3,000). Short-term and long-term allograft outcomes 
      were compared between groups. RESULTS: In the high BMI-sensitized group, the 
      decline in allograft function was higher than that in the other three groups. 
      Death-censored graft loss (DCGL) rates were highest in the high BMI-sensitized 
      group (4 of 21 [19.0%], p = 0.04). In the multivariable Cox regression hazard 
      regression model analysis, the hazard ratio (HR) for DCGL was intensified when 
      high BMI and presensitization statuses were combined (HR, 3.75; p = 0.03); these 
      statuses significantly interacted with each other (p-value for interaction = 
      0.008). CONCLUSION: Our results suggest that presensitization to HLA and high BMI 
      might have an interactive adverse impact on allograft outcomes in KTRs.
FAU - Park, Yohan
AU  - Park Y
AD  - Transplantation Research Center, Seoul St. Mary's Hospital, College of Medicine, 
      The Catholic University of Korea, Seoul, Republic of Korea.
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Lee, Hanbi
AU  - Lee H
AD  - Transplantation Research Center, Seoul St. Mary's Hospital, College of Medicine, 
      The Catholic University of Korea, Seoul, Republic of Korea.
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Ko, Eun Jeong
AU  - Ko EJ
AD  - Transplantation Research Center, Seoul St. Mary's Hospital, College of Medicine, 
      The Catholic University of Korea, Seoul, Republic of Korea.
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Lee, Sua
AU  - Lee S
AD  - Division of Nephrology, Department of Internal Medicine, Seoul National 
      University Hospital, College of Medicine, Seoul National University, Seoul, 
      Republic of Korea.
FAU - Ban, Tae Hyun
AU  - Ban TH
AD  - Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Min, Ji-Won
AU  - Min JW
AD  - Division of Nephrology, Department of Internal Medicine, Bucheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Yoon, Hye-Eun
AU  - Yoon HE
AD  - Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Oh, Eun-Jee
AU  - Oh EJ
AD  - Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
FAU - Yang, Chul Woo
AU  - Yang CW
AD  - Transplantation Research Center, Seoul St. Mary's Hospital, College of Medicine, 
      The Catholic University of Korea, Seoul, Republic of Korea.
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Chung, Byung Ha
AU  - Chung BH
AD  - Transplantation Research Center, Seoul St. Mary's Hospital, College of Medicine, 
      The Catholic University of Korea, Seoul, Republic of Korea.
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
LA  - eng
GR  - HI20C0317/Ministry of Health and Welfare/
PT  - Journal Article
DEP - 20210430
PL  - Korea (South)
TA  - Kidney Res Clin Pract
JT  - Kidney research and clinical practice
JID - 101586778
PMC - PMC8237112
OTO - NOTNLM
OT  - Body mass index
OT  - Graft survival
OT  - Kidney transplantation
OT  - Presensitization
COIS- Conflict of interest All authors have no conflicts of interest to declare.
EDAT- 2021/05/25 06:00
MHDA- 2021/05/25 06:01
PMCR- 2021/06/01
CRDT- 2021/05/24 03:54
PHST- 2020/11/12 00:00 [received]
PHST- 2020/12/14 00:00 [accepted]
PHST- 2021/05/25 06:00 [pubmed]
PHST- 2021/05/25 06:01 [medline]
PHST- 2021/05/24 03:54 [entrez]
PHST- 2021/06/01 00:00 [pmc-release]
AID - j.krcp.20.216 [pii]
AID - j-krcp-20-216 [pii]
AID - 10.23876/j.krcp.20.216 [doi]
PST - ppublish
SO  - Kidney Res Clin Pract. 2021 May;40(2):304-316. doi: 10.23876/j.krcp.20.216. Epub 
      2021 Apr 30.