PMID- 34025119
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 15
DP  - 2021
TI  - OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis.
PG  - 2025-2036
LID - 10.2147/OPTH.S309703 [doi]
AB  - OBJECTIVE: To evaluate the agreement between the peripapillary retinal nerve 
      fiber layer (pRNFL) and foveal thickness (FT) measurements among three different 
      spectral domain-optical coherence tomography (SD-OCT) instruments in a sample of 
      multiple sclerosis (MS) patients and a healthy age-matched control group. 
      METHODS: An observational cross-sectional study with three groups: healthy 
      subjects and MS patients w/w a previous clinical diagnosis of optic neuritis (ON) 
      was conducted. The pRNFL and FT were measured using three different SD-OCT 
      instruments (OCT PRIMUS 200 and OCT CIRRUS 500 SD-OCT [Carl Zeiss Meditec] and 
      OCT 3D 2000 [Topcon]). RESULTS: Twenty eyes from 10 healthy subjects matched in 
      age with MS patients without a previous history of eye disease and 62 MS eyes 
      from 31 MS patients (29 eyes without history of ON and 33 eyes with history of 
      ON) were enrolled. Healthy subjects and MS patients without ON did not show 
      differences between the pRNFL and FT thickness (P>0.99) with any of the 
      instruments. However, MS eyes with a previous episode of ON showed thinner pRNFL 
      and FT (P<0.01). PRIMUS and CIRRUS OCT showed better agreement of the pRNLF and 
      FT in both healthy and MS eyes. However, 3D OCT showed less agreement in the 
      pRNFL measurement with CIRRUS in both healthy and MS eyes. INTERPRETATION: 
      Although OCT is a valuable technology to improve MS patient assessment, 
      differences between devices must be taken into account. It is necessary to create 
      an international group that standardizes the measurement conditions and above all 
      that provides reference bases for normal subjects.
CI  - (c) 2021 Para-Prieto et al.
FAU - Para-Prieto, Marta
AU  - Para-Prieto M
AD  - Universidad de Valladolid, Instituto Universitario de Oftalmobiologia Aplicada 
      (IOBA Eye Institute), Valladolid, 47011, Spain.
AD  - Hospital Clinico Universitario, Department of Ophthalmology, Valladolid, 47005, 
      Spain.
FAU - Martin, Raul
AU  - Martin R
AUID- ORCID: 0000-0001-7156-619X
AD  - Universidad de Valladolid, Instituto Universitario de Oftalmobiologia Aplicada 
      (IOBA Eye Institute), Valladolid, 47011, Spain.
AD  - Universidad de Valladolid, Departamento de Fisica Teorica, Atomica y Optica, 
      Valladolid, 47011, Spain.
AD  - Plymouth University, Faculty of Health and Human Sciences, Plymouth, UK.
FAU - Crespo, Sara
AU  - Crespo S
AUID- ORCID: 0000-0003-2066-3621
AD  - Hospital Clinico Universitario, Department of Ophthalmology, Valladolid, 47005, 
      Spain.
FAU - Mena-Garcia, Laura
AU  - Mena-Garcia L
AD  - Universidad de Valladolid, Instituto Universitario de Oftalmobiologia Aplicada 
      (IOBA Eye Institute), Valladolid, 47011, Spain.
FAU - Valisena, Andres
AU  - Valisena A
AD  - Hospital Clinico Universitario, Department of Ophthalmology, Valladolid, 47005, 
      Spain.
FAU - Cordero, Lisandro
AU  - Cordero L
AD  - Universidad de Valladolid, Instituto Universitario de Oftalmobiologia Aplicada 
      (IOBA Eye Institute), Valladolid, 47011, Spain.
FAU - Gonzalez Fernandez, Gloria
AU  - Gonzalez Fernandez G
AD  - Hospital Clinico Universitario, Department of Ophthalmology, Valladolid, 47005, 
      Spain.
FAU - Arenillas, Juan F
AU  - Arenillas JF
AD  - Hospital Clinico Universitario, Department of Neurology, Valladolid, 47005, 
      Spain.
FAU - Tellez, Nieves
AU  - Tellez N
AD  - Hospital Clinico Universitario, Department of Neurology, Valladolid, 47005, 
      Spain.
FAU - Pastor, Jose Carlos
AU  - Pastor JC
AUID- ORCID: 0000-0001-5934-7306
AD  - Universidad de Valladolid, Instituto Universitario de Oftalmobiologia Aplicada 
      (IOBA Eye Institute), Valladolid, 47011, Spain.
AD  - Hospital Clinico Universitario, Department of Ophthalmology, Valladolid, 47005, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20210514
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC8132465
OTO - NOTNLM
OT  - foveal thickness; FT
OT  - multiple sclerosis; MS
OT  - retinal nerve fiber layer; RNFL
OT  - spectral-domain optical coherence tomography; SD-OCT
OT  - variability
COIS- Dr Juan F. Arenillas reports personal fees from Boehringer Ingelheim, personal 
      fees from Bayer, personal fees from Medtronic, personal fees from Daiichi Sankyo, 
      personal fees from BMS-Pfizer, personal fees from Amgen, personal fees from Astra 
      Zeneca, grants from Spanish Ministry Economy, grants from European Commission, 
      grants from Castilla y Leon Department of Education, outside the submitted work. 
      None of the authors has any other financial or proprietary interest in neither 
      material nor method mentioned.
EDAT- 2021/05/25 06:00
MHDA- 2021/05/25 06:01
PMCR- 2021/05/14
CRDT- 2021/05/24 08:00
PHST- 2021/03/05 00:00 [received]
PHST- 2021/04/08 00:00 [accepted]
PHST- 2021/05/24 08:00 [entrez]
PHST- 2021/05/25 06:00 [pubmed]
PHST- 2021/05/25 06:01 [medline]
PHST- 2021/05/14 00:00 [pmc-release]
AID - 309703 [pii]
AID - 10.2147/OPTH.S309703 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2021 May 14;15:2025-2036. doi: 10.2147/OPTH.S309703. eCollection 
      2021.