PMID- 34025550
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210526
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 12
DP  - 2021
TI  - Brain Volume and Perception of Cognitive Impairment in People With Multiple 
      Sclerosis and Their Caregivers.
PG  - 636463
LID - 10.3389/fneur.2021.636463 [doi]
LID - 636463
AB  - Background: Cognitive impairment (CI) is common in people with multiple sclerosis 
      (pwMS). The assessment of CI is based on neuropsychological tests and accurate 
      anamnesis, involving the patients and caregivers (CG). This study aimed to assess 
      the complex interplay between self-perception of CI, objective CI and the brain 
      atrophy of MS patients, also exploring the possible differences with CI evaluated 
      by caregivers. Methods: Relapsing pwMS were enrolled in this study. Subjects 
      underwent neuropsychological examination using the Brief Cognitive Assessment for 
      Multiple Sclerosis (BICAMS) and evaluation of self-reported cognitive status 
      using the patient-version of the Multiple Sclerosis Neuropsychological 
      Questionnaire (p-MSNQ). Depression and anxiety were also evaluated using the Back 
      Depression Inventory-version II (BDI-II) and Zung Anxiety Scale. Brain MRI images 
      were acquired and brain volumes estimated. For each patient that was enrolled, we 
      spoke to a caregiver and collected their perception of the patient's CI using the 
      MSNQ- Caregiver version. Results: Ninety-five MS subjects with their caregivers 
      were enrolled. CI was detected in 51 (53.7%) patients. We found a significant 
      correlation (p < 0.001) between BICAMS T scores and lower whole brain (Rho = 
      0.51), gray matter (Rho = 0.54), cortical gray matter (Rho = 0.51) volumes and 
      lower p-MSNQ (Rho = 0.31), and cg-MSNQ (Rho = 0.41) scores. Multivariate logistic 
      regression showed that p-MSNQ is related to a patient's anxiety to evaluate by 
      Zung Score (p < 0.001) while cg-MSNQ to patient's brain volume (p = 0.01). 
      Conclusion: Our data confirm that neuropsychological evaluation results are 
      related to the perception of CI and brain volume measures and highlight the 
      importance of the caregiver's perception for cognitive assessment of pwMS.
CI  - Copyright (c) 2021 Fenu, Lorefice, Carta, Arru, Carta, Fronza, Coghe, Frau, Contu, 
      Barracciu and Cocco.
FAU - Fenu, Giuseppe
AU  - Fenu G
AD  - Multiple Sclerosis Center, Binaghi Hospital, Azienda Tutela della Salute (ATS) 
      Sardegna, Cagliari, Italy.
FAU - Lorefice, Lorena
AU  - Lorefice L
AD  - Multiple Sclerosis Center, Binaghi Hospital, Azienda Tutela della Salute (ATS) 
      Sardegna, Cagliari, Italy.
FAU - Carta, Elisa
AU  - Carta E
AD  - Multiple Sclerosis Center, Department of Medical Sciences and Public Health, 
      University of Cagliari, Cagliari, Italy.
FAU - Arru, Mauro
AU  - Arru M
AD  - Multiple Sclerosis Center, Department of Medical Sciences and Public Health, 
      University of Cagliari, Cagliari, Italy.
FAU - Carta, Alice
AU  - Carta A
AD  - Multiple Sclerosis Center, Department of Medical Sciences and Public Health, 
      University of Cagliari, Cagliari, Italy.
FAU - Fronza, Marzia
AU  - Fronza M
AD  - Multiple Sclerosis Center, Department of Medical Sciences and Public Health, 
      University of Cagliari, Cagliari, Italy.
FAU - Coghe, Giancarlo
AU  - Coghe G
AD  - Multiple Sclerosis Center, Binaghi Hospital, Azienda Tutela della Salute (ATS) 
      Sardegna, Cagliari, Italy.
FAU - Frau, Jessica
AU  - Frau J
AD  - Multiple Sclerosis Center, Binaghi Hospital, Azienda Tutela della Salute (ATS) 
      Sardegna, Cagliari, Italy.
FAU - Contu, Franco
AU  - Contu F
AD  - Radiology Unit, Binaghi Hospital, Azienda Tutela della Salute (ATS) Sardegna, 
      Cagliari, Italy.
FAU - Barracciu, Maria Antonietta
AU  - Barracciu MA
AD  - Radiology Unit, Binaghi Hospital, Azienda Tutela della Salute (ATS) Sardegna, 
      Cagliari, Italy.
FAU - Cocco, Eleonora
AU  - Cocco E
AD  - Multiple Sclerosis Center, Department of Medical Sciences and Public Health, 
      University of Cagliari, Cagliari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210506
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC8136416
OTO - NOTNLM
OT  - brain volume
OT  - caregiver
OT  - cognitive impairment
OT  - multiple sclerosis
OT  - patients
COIS- GF was an editorial board member of BMC Neurology and received a travel grant, 
      speaker fee, and consultancy from Biogen Idec, Sanofi, Teva, Admirall, Genzyme, 
      Merck Serono, and Novartis. LL, GC, JF, and ECo received travel grants, speaker 
      fees, and consultancy from Biogen Idec, Sanofi, Teva, Admirall, Genzyme, Merck 
      Serono, and Novartis. MB and FC received travel grants from Biogen Idec. The 
      remaining authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/05/25 06:00
MHDA- 2021/05/25 06:01
PMCR- 2021/05/06
CRDT- 2021/05/24 08:04
PHST- 2020/12/01 00:00 [received]
PHST- 2021/03/24 00:00 [accepted]
PHST- 2021/05/24 08:04 [entrez]
PHST- 2021/05/25 06:00 [pubmed]
PHST- 2021/05/25 06:01 [medline]
PHST- 2021/05/06 00:00 [pmc-release]
AID - 10.3389/fneur.2021.636463 [doi]
PST - epublish
SO  - Front Neurol. 2021 May 6;12:636463. doi: 10.3389/fneur.2021.636463. eCollection 
      2021.