PMID- 34027826
OWN - NLM
STAT- MEDLINE
DCOM- 20220304
LR  - 20220304
IS  - 2154-4700 (Electronic)
IS  - 1933-8244 (Linking)
VI  - 77
IP  - 2
DP  - 2022
TI  - Effect of heavy metals on ventricular repolarization and depolarization in the 
      Metropolitan Manila Development Authority (MMDA) traffic enforcers' health study.
PG  - 87-95
LID - 10.1080/19338244.2020.1853017 [doi]
AB  - We examined the relationships between blood heavy metals [cadmium (B-Cd), mercury 
      (B-Hg), and lead (B-Pb)] and heart rate-corrected QT interval (QTc), JT interval 
      (JTc), and QRS complex duration (QRSc), electrocardiogram markers of ventricular 
      repolarization and depolarization among 60 traffic enforcers in the MMDA traffic 
      enforcers' health study. We fitted regression models to estimate the mean change 
      effect on QTc, JTc, and QRSc, of B-Cd, B-Hg, and B-Pb concentrations, adjusted 
      for potential confounding factors. We looked at effect modification by sex and 
      smoking status. An interquartile range increase in B-Cd (0.9 mug/L) was related to 
      a 6.6% increase in mean QRSc [95% confidence interval (CI): 2.5, 10.8], and a 
      1.7% increase in mean QTc (95% CI: 0.2, 3.3). We also found that the associations 
      between B-Cd and QRSc and QTc were higher among participants who were never 
      smokers than ever smokers. Moreover, the association between B-Cd and QRSc was 
      also higher among males than females.
FAU - Regencia, Zypher Jude G
AU  - Regencia ZJG
AD  - Exposure Assessment, Epidemiology, and Risk Lab, Institute of Clinical 
      Epidemiology, National Institutes of Health, University of the 
      Philippines-Manila, City of Manila, Philippines.
FAU - Dalmacion, Godofreda V
AU  - Dalmacion GV
AD  - Exposure Assessment, Epidemiology, and Risk Lab, Institute of Clinical 
      Epidemiology, National Institutes of Health, University of the 
      Philippines-Manila, City of Manila, Philippines.
AD  - Department of Clinical Epidemiology, College of Medicine, University of the 
      Philippines-Manila, City of Manila, Philippines.
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of the 
      Philippines-Manila, City of Manila, Philippines.
FAU - Baja, Emmanuel S
AU  - Baja ES
AD  - Exposure Assessment, Epidemiology, and Risk Lab, Institute of Clinical 
      Epidemiology, National Institutes of Health, University of the 
      Philippines-Manila, City of Manila, Philippines.
AD  - Department of Clinical Epidemiology, College of Medicine, University of the 
      Philippines-Manila, City of Manila, Philippines.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201202
PL  - United States
TA  - Arch Environ Occup Health
JT  - Archives of environmental & occupational health
JID - 101282564
RN  - 0 (Metals, Heavy)
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Adult
MH  - Cadmium/*blood
MH  - Electrocardiography
MH  - Female
MH  - *Heart Rate
MH  - Humans
MH  - Lead/*blood
MH  - Male
MH  - Mercury/*blood
MH  - Metals, Heavy/blood
MH  - Occupational Exposure/*adverse effects
MH  - Philippines/epidemiology
MH  - Traffic-Related Pollution/*adverse effects
MH  - *Ventricular Function
OTO - NOTNLM
OT  - Blood cadmium
OT  - MMDA ' Health Study
OT  - blood lead
OT  - blood mercury
OT  - sex
OT  - smoking
OT  - traffic enforcers
OT  - ventricular depolarization and repolarizationtraffic enforcers
EDAT- 2021/05/25 06:00
MHDA- 2022/03/05 06:00
CRDT- 2021/05/24 09:56
PHST- 2021/05/25 06:00 [pubmed]
PHST- 2022/03/05 06:00 [medline]
PHST- 2021/05/24 09:56 [entrez]
AID - 10.1080/19338244.2020.1853017 [doi]
PST - ppublish
SO  - Arch Environ Occup Health. 2022;77(2):87-95. doi: 10.1080/19338244.2020.1853017. 
      Epub 2020 Dec 2.