PMID- 34027925
OWN - NLM
STAT- MEDLINE
DCOM- 20211126
LR  - 20230320
IS  - 1528-1159 (Electronic)
IS  - 0362-2436 (Linking)
VI  - 46
IP  - 24
DP  - 2021 Dec 15
TI  - Machine Learning Approach in Predicting Clinically Significant Improvements After 
      Surgery in Patients with Cervical Ossification of the Posterior Longitudinal 
      Ligament.
PG  - 1683-1689
LID - 10.1097/BRS.0000000000004125 [doi]
AB  - STUDY DESIGN: A retrospective analysis of prospectively collected data. 
      OBJECTIVE: This study aimed to create a prognostic model for surgical outcomes in 
      patients with cervical ossification of the posterior longitudinal ligament (OPLL) 
      using machine learning (ML). SUMMARY OF BACKGROUND DATA: Determining surgical 
      outcomes helps surgeons provide prognostic information to patients and manage 
      their expectations. ML is a mathematical model that finds patterns from a large 
      sample of data and makes predictions outperforming traditional statistical 
      methods. METHODS: Of 478 patients, 397 and 370 patients had complete follow-up 
      information at 1 and 2 years, respectively, and were included in the analysis. A 
      minimal clinically important difference (MCID) was defined as an acquired 
      Japanese Orthopedic Association (JOA) score of >/=2.5 points, after which a ML 
      model that predicts whether MCID can be achieved 1 and 2 years after surgery was 
      created. Patient background, clinical symptoms, and imaging findings were used as 
      variables for analysis. The ML model was created using LightGBM, XGBoost, random 
      forest, and logistic regression, after which the accuracy and area under the 
      receiver-operating characteristic curve (AUC) were calculated. RESULTS: The mean 
      JOA score was 10.3 preoperatively, 13.4 at 1 year after surgery, and 13.5 at 
      2 years after surgery. XGBoost showed the highest AUC (0.72) and high accuracy 
      (67.8) for predicting MCID at 1 year, whereas random forest had the highest AUC 
      (0.75) and accuracy (69.6) for predicting MCID at 2 years. Among the included 
      features, total preoperative JOA score, duration of symptoms, body weight, 
      sensory function of the lower extremity sub-score of the JOA, and age were 
      identified as having the most significance in most of ML models. CONCLUSION: 
      Constructing a prognostic ML model for surgical outcomes in patients with OPLL is 
      feasible, suggesting the potential application of ML for predictive models of 
      spinal surgery.Level of Evidence: 4.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Maki, Satoshi
AU  - Maki S
AD  - Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 
      Chiba, Chiba, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Furuya, Takeo
AU  - Furuya T
AD  - Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 
      Chiba, Chiba, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Yoshii, Toshitaka
AU  - Yoshii T
AD  - Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, 
      Tokyo, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Egawa, Satoru
AU  - Egawa S
AD  - Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, 
      Tokyo, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Sakai, Kenichiro
AU  - Sakai K
AD  - Department of Orthopedic Surgery, Saiseikai Kawaguchi General Hospital, 
      Kawaguchi, Saitama, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Kusano, Kazuo
AU  - Kusano K
AD  - Department of Orthopedic Surgery, Kudanzaka Hospital, Chiyoda-ku, Tokyo, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Nakagawa, Yukihiro
AU  - Nakagawa Y
AD  - Department of Orthopedic Surgery, Wakayama Medical University Kihoku Hospital, 
      Itogun, Wakayama, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Hirai, Takashi
AU  - Hirai T
AD  - Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, 
      Tokyo, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Wada, Kanichiro
AU  - Wada K
AD  - Department of Orthopedic Surgery, Hirosaki University Graduate School of 
      Medicine, Hirosaki, Aomori, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Katsumi, Keiichi
AU  - Katsumi K
AD  - Department of Orthopedic Surgery, Niigata University Medical and Dental General 
      Hospital, Niigata, Niigata, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Fujii, Kengo
AU  - Fujii K
AD  - Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, 
      Tsukuba, Ibaraki, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Kimura, Atsushi
AU  - Kimura A
AD  - Department of Orthopedics, Jichi Medical University, Shimotsuke, Tochigi, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Nagoshi, Narihito
AU  - Nagoshi N
AD  - Department of Orthopedic Surgery, School of Medicine, Keio University, 
      Shinjuku-ku, Tokyo japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Kanchiku, Tsukasa
AU  - Kanchiku T
AD  - Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Ube, 
      Yamaguchi, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Nagamoto, Yukitaka
AU  - Nagamoto Y
AD  - Department of Orthopedic Surgery, Osaka Rosai Hospital, Sakai, Osaka, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Oshima, Yasushi
AU  - Oshima Y
AD  - Department of Orthopedic Surgery, The University of Tokyo Hospital, Bunkyo-ku, 
      Tokyo, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Ando, Kei
AU  - Ando K
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Aichi, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Takahata, Masahiko
AU  - Takahata M
AD  - Orthopedic Surgery, Reconstructive Surgery and Rehabilitation Medicine, Division 
      of Advanced Medical Science, Hokkaido University, Graduate School of Medicine, 
      Sapporo, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Mori, Kanji
AU  - Mori K
AD  - Department of Orthopedic Surgery, Shiga University of Medical Science, Otsu, 
      Shiga, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Nakajima, Hideaki
AU  - Nakajima H
AD  - Department of Orthopedics and Rehabilitation Medicine, University of Fukui 
      Faculty of Medical Sciences, Matsuoka, Fukui, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Murata, Kazuma
AU  - Murata K
AD  - Department of Orthopedic Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, 
      Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Matsunaga, Shunji
AU  - Matsunaga S
AD  - Department Department of Orthopedic Surgery, Imakiire General Hospital, 
      Kagoshima, Kagoshima, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Kaito, Takashi
AU  - Kaito T
AD  - Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 
      Suita, Osaka, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Yamada, Kei
AU  - Yamada K
AD  - Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, 
      Fukuoka, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Kobayashi, Sho
AU  - Kobayashi S
AD  - Department of Orthopedic Surgery, Hamamatsu University School of Medicine, 
      Hamamatsu, Shizuoka, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Kato, Satoshi
AU  - Kato S
AD  - Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa 
      University, Kanazawa, Ishikawa, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Ohba, Tetsuro
AU  - Ohba T
AD  - Department of Orthopedic Surgery, University of Yamanashi, Chuo, Yamanashi, 
      Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Inami, Satoshi
AU  - Inami S
AD  - Department of Orthopedic Surgery, Dokkyo Medical University School of Medicine, 
      Shimotsuga-gun, Tochigi, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Fujibayashi, Shunsuke
AU  - Fujibayashi S
AD  - Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto, Kyoto, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Katoh, Hiroyuki
AU  - Katoh H
AD  - Department of Orthopedic Surgery, Surgical Science, Tokai University School of 
      Medicine, isehara, Kanagawa, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Kanno, Haruo
AU  - Kanno H
AD  - Department of Orthopedic Surgery, Tohoku University School of Medicine, Sendai, 
      Miyagi, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Imagama, Shiro
AU  - Imagama S
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Aichi, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Koda, Masao
AU  - Koda M
AD  - Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, 
      Tsukuba, Ibaraki, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Kawaguchi, Yoshiharu
AU  - Kawaguchi Y
AD  - Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama, 
      Toyama, Toyama, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Takeshita, Katsushi
AU  - Takeshita K
AD  - Department of Orthopedics, Jichi Medical University, Shimotsuke, Tochigi, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Matsumoto, Morio
AU  - Matsumoto M
AD  - Department of Orthopedic Surgery, School of Medicine, Keio University, 
      Shinjuku-ku, Tokyo japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Ohtori, Seiji
AU  - Ohtori S
AD  - Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 
      Chiba, Chiba, Japan.
FAU - Yamazaki, Masashi
AU  - Yamazaki M
AD  - Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, 
      Tsukuba, Ibaraki, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
FAU - Okawa, Atsushi
AU  - Okawa A
AD  - Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, 
      Tokyo, Japan.
AD  - Japanese Multicenter Research Organization for Ossification of the Spinal 
      Ligament, Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
SB  - IM
MH  - Cervical Vertebrae/diagnostic imaging
MH  - Humans
MH  - *Longitudinal Ligaments/pathology/surgery
MH  - Machine Learning
MH  - *Osteogenesis
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2021/05/25 06:00
MHDA- 2021/11/27 06:00
CRDT- 2021/05/24 10:01
PHST- 2021/05/25 06:00 [pubmed]
PHST- 2021/11/27 06:00 [medline]
PHST- 2021/05/24 10:01 [entrez]
AID - 00007632-202112150-00007 [pii]
AID - 10.1097/BRS.0000000000004125 [doi]
PST - ppublish
SO  - Spine (Phila Pa 1976). 2021 Dec 15;46(24):1683-1689. doi: 
      10.1097/BRS.0000000000004125.