PMID- 34030288
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 780
DP  - 2021 Aug 1
TI  - Serum lipids mediate the relationship of multiple polyaromatic hydrocarbons on 
      non-alcoholic fatty liver disease: A population-based study.
PG  - 146563
LID - S0048-9697(21)01631-4 [pii]
LID - 10.1016/j.scitotenv.2021.146563 [doi]
AB  - Polyaromatic hydrocarbons (PAHs) are recognized as organic pollutants with liver 
      toxicity. However, the relationship between PAHs and nonalcoholic fatty liver 
      disease (NAFLD) is unclear in humans. The aim of this study was to investigate 
      the levels of PAHs in the US population and their association with the risk of 
      NAFLD. We investigated urinary levels of nine PAHs in 2436 participants from the 
      National Health and Nutrition Examination Survey (NHANES) between 2005 and 2012, 
      including 1-Hydroxynapthalene (1-OHN), 2-Hydroxynapthalene (2-OHN), 
      3-Hydroxyfluorene (3-OHF), 2-Hydroxyfluorene (2-OHF), 3-Hydroxyphenanthrene 
      (3-OHPhe), 1-Hydroxyphenanthrene (1-OHPhe), 2-Hydroxyphenanthrene (2-OHPhe), 
      1-Hydroxypyrene (1-OHPyr), 9-Hydroxyfluorene (9-OHF). Logistic regression models 
      were used to estimate the relationship between single PAH and NAFLD. Assessment 
      of the overall effect of multiple PAH mixtures on NAFLD using Bayesian kernel 
      machine regression (BKMR) model. There were 698 participants diagnosed with NAFLD 
      in the study group. After adjusting for related covariates such as sex, age, 
      race, education, marital status, poverty income ratio (PIR), body mass index 
      (BMI), total energy intake, smoking, hypertension, and diabetes, logistic 
      regression analysis showed that compared to the low tertile (T1), the odds ratio 
      of the high tertile (T3) was 1.70 (95%CI: 1.26-2.29, p = 0.001) for total PAHs, 
      1.50 (95%CI: 1.11-2.03, p = 0.008) for 2-OHN, 1.75 (95%CI: 1.31-2.34, p < 0.001) 
      for 2-OHPhe, 1.59 (95%CI: 1.18-2.14, p = 0.002) for 9-OHF and 0.63 (95%CI: 
      0.46-0.87, p = 0.004) for 3-OHF. In the BKMR model, we found that the overall 
      effect of the nine PAH mixtures was positively associated with the risk of NAFLD. 
      Mediation analysis showed that HDL and TG mediated the association between PAHs 
      and NAFLD. Our study suggests that multiple PAHs mixtures exposure may induce 
      NAFLD by mediating serum lipids in human metabolism.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Hu, Zhengyu
AU  - Hu Z
AD  - Department of General Surgery, Shanghai Tenth People's Hospital, Affiliated to 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Gastroenterology, Shanghai Tenth People's Hospital, Affiliated to 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Yang, Yuexin
AU  - Yang Y
AD  - Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and 
      Peking Union Medical College, China.
FAU - Yu, Weidi
AU  - Yu W
AD  - Department of General Surgery, Shanghai Tenth People's Hospital, Affiliated to 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Xie, Wangcheng
AU  - Xie W
AD  - Department of General Surgery, Shanghai Tenth People's Hospital, Affiliated to 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Song, Guodong
AU  - Song G
AD  - Department of General Surgery, Shanghai Tenth People's Hospital, Affiliated to 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Qian, Yaqin
AU  - Qian Y
AD  - Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province 230032, China.
FAU - Song, Zhenshun
AU  - Song Z
AD  - Department of General Surgery, Shanghai Tenth People's Hospital, Affiliated to 
      Tongji University School of Medicine, Shanghai 200072, China. Electronic address: 
      zs_song@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210322
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Biomarkers)
RN  - 0 (Lipids)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
SB  - IM
MH  - Bayes Theorem
MH  - Biomarkers
MH  - Environmental Exposure/analysis
MH  - Humans
MH  - Lipids
MH  - *Non-alcoholic Fatty Liver Disease/chemically induced/epidemiology
MH  - Nutrition Surveys
MH  - *Polycyclic Aromatic Hydrocarbons
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - NHANES
OT  - Non-alcoholic fatty liver disease
OT  - Polyaromatic hydrocarbons
OT  - Serum lipids
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/05/26 06:00
MHDA- 2021/05/29 06:00
CRDT- 2021/05/25 01:03
PHST- 2020/12/14 00:00 [received]
PHST- 2021/03/12 00:00 [revised]
PHST- 2021/03/14 00:00 [accepted]
PHST- 2021/05/25 01:03 [entrez]
PHST- 2021/05/26 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
AID - S0048-9697(21)01631-4 [pii]
AID - 10.1016/j.scitotenv.2021.146563 [doi]
PST - ppublish
SO  - Sci Total Environ. 2021 Aug 1;780:146563. doi: 10.1016/j.scitotenv.2021.146563. 
      Epub 2021 Mar 22.