PMID- 34031362 OWN - NLM STAT- MEDLINE DCOM- 20210714 LR - 20210714 IS - 2158-3188 (Electronic) IS - 2158-3188 (Linking) VI - 11 IP - 1 DP - 2021 May 24 TI - Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis. PG - 312 LID - 10.1038/s41398-021-01409-4 [doi] LID - 312 AB - Negative symptoms occur frequently in individuals at clinical high risk (CHR) for psychosis and contribute to functional impairments. The aim of this study was to predict negative symptom severity in CHR after 9 months. Predictive models either included baseline negative symptoms measured with the Structured Interview for Psychosis-Risk Syndromes (SIPS-N), whole-brain gyrification, or both to forecast negative symptoms of at least moderate severity in 94 CHR. We also conducted sequential risk stratification to stratify CHR into different risk groups based on the SIPS-N and gyrification model. Additionally, we assessed the models' ability to predict functional outcomes in CHR and their transdiagnostic generalizability to predict negative symptoms in 96 patients with recent-onset psychosis (ROP) and 97 patients with recent-onset depression (ROD). Baseline SIPS-N and gyrification predicted moderate/severe negative symptoms with significant balanced accuracies of 68 and 62%, while the combined model achieved 73% accuracy. Sequential risk stratification stratified CHR into a high (83%), medium (40-64%), and low (19%) risk group regarding their risk of having moderate/severe negative symptoms at 9 months follow-up. The baseline SIPS-N model was also able to predict social (61%), but not role functioning (59%) at above-chance accuracies, whereas the gyrification model achieved significant accuracies in predicting both social (76%) and role (74%) functioning in CHR. Finally, only the baseline SIPS-N model showed transdiagnostic generalization to ROP (63%). This study delivers a multimodal prognostic model to identify those CHR with a clinically relevant negative symptom severity and functional impairments, potentially requiring further therapeutic consideration. FAU - Hauke, Daniel J AU - Hauke DJ AUID- ORCID: 0000-0003-1772-9239 AD - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. daniel.hauke@unibas.ch. AD - Department of Mathematics and Computer Science, University of Basel, Basel, Switzerland. daniel.hauke@unibas.ch. FAU - Schmidt, Andre AU - Schmidt A AUID- ORCID: 0000-0001-6055-8397 AD - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. FAU - Studerus, Erich AU - Studerus E AD - Department of Psychology, University of Basel, Basel, Switzerland. FAU - Andreou, Christina AU - Andreou C AD - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. AD - Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, Germany. FAU - Riecher-Rossler, Anita AU - Riecher-Rossler A AUID- ORCID: 0000-0001-6361-8789 AD - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. FAU - Radua, Joaquim AU - Radua J AD - Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain. AD - Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. AD - Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. FAU - Kambeitz, Joseph AU - Kambeitz J AUID- ORCID: 0000-0002-8988-3959 AD - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. FAU - Ruef, Anne AU - Ruef A AD - Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany. FAU - Dwyer, Dominic B AU - Dwyer DB AD - Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany. FAU - Kambeitz-Ilankovic, Lana AU - Kambeitz-Ilankovic L AD - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. AD - Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany. FAU - Lichtenstein, Theresa AU - Lichtenstein T AD - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. FAU - Sanfelici, Rachele AU - Sanfelici R AD - Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany. AD - Max Planck School of Cognition, Leipzig, Germany. FAU - Penzel, Nora AU - Penzel N AD - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. AD - Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany. FAU - Haas, Shalaila S AU - Haas SS AUID- ORCID: 0000-0003-1385-1050 AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Antonucci, Linda A AU - Antonucci LA AD - Department of Education, Psychology, Communication, University of Bari Aldo Moro, Bari, Italy. FAU - Lalousis, Paris Alexandros AU - Lalousis PA AUID- ORCID: 0000-0001-9642-3080 AD - Institute for Mental Health and Centre for Human Brain Health, University of Birmingham, Birmingham, UK. FAU - Chisholm, Katharine AU - Chisholm K AD - Institute for Mental Health, University of Birmingham, Birmingham, UK. FAU - Schultze-Lutter, Frauke AU - Schultze-Lutter F AUID- ORCID: 0000-0003-1956-9574 AD - Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Dusseldorf, Germany. AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. AD - Department of Psychology and Mental Health, Faculty of Psychology, Airlangga University, Surabaya, Indonesia. FAU - Ruhrmann, Stephan AU - Ruhrmann S AUID- ORCID: 0000-0002-6022-2364 AD - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. FAU - Hietala, Jarmo AU - Hietala J AUID- ORCID: 0000-0002-3179-6780 AD - Department of Psychiatry, University of Turku, Turku, Finland. FAU - Brambilla, Paolo AU - Brambilla P AUID- ORCID: 0000-0002-4021-8456 AD - Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. AD - Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. FAU - Koutsouleris, Nikolaos AU - Koutsouleris N AUID- ORCID: 0000-0001-6825-6262 AD - Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany. FAU - Meisenzahl, Eva AU - Meisenzahl E AD - Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Dusseldorf, Germany. FAU - Pantelis, Christos AU - Pantelis C AUID- ORCID: 0000-0002-9565-0238 AD - Melbourne Neuropsychiatry Centre, University of Melbourne & Melbourne Health, Carlton South, VIC, Australia. FAU - Rosen, Marlene AU - Rosen M AD - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. FAU - Salokangas, Raimo K R AU - Salokangas RKR AD - Department of Psychiatry, University of Turku, Turku, Finland. FAU - Upthegrove, Rachel AU - Upthegrove R AUID- ORCID: 0000-0001-8204-5103 AD - Institute for Mental Health and School of Psychology, University of Birmingham, Birmingham, UK. FAU - Wood, Stephen J AU - Wood SJ AD - Institute for Mental Health, University of Birmingham, Birmingham, UK. AD - Orygen, Melbourne, VIC, Australia. AD - Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia. FAU - Borgwardt, Stefan AU - Borgwardt S AUID- ORCID: 0000-0002-5792-3987 AD - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. AD - Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, Germany. CN - PRONIA Group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210524 PL - United States TA - Transl Psychiatry JT - Translational psychiatry JID - 101562664 SB - IM MH - Brain MH - Humans MH - *Prodromal Symptoms MH - Prognosis MH - *Psychotic Disorders/diagnosis MH - Risk Factors PMC - PMC8144430 COIS- This work was funded by the European Union under the 7th Framework Programme (grant number 602152). D.J.H.'s work was supported by the Swiss National Science Foundation (Ambizione grant; grant number 167952). J.R.'s work was supported by Miguel Servet Research Contract (CPII19/00009) and Research Projects PI19/00394 from the Plan Nacional de I + D + i, the Instituto de Salud Carlos III-Subdireccion General de Evaluacion y Fomento de la Investigacion and the European Regional Development Fund (FEDER, 'Investing in your future'). R.S. received honoraria for one lecture from Lundbeck outside the submitted work and funding from BMBF and the Max Planck Society. C.P. has received honoraria for talks at educational meetings and has served on an advisory board for Lundbeck, Australia Pty Ltd, and was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1105825), an NHMRC L3 Investigator Grant (1196508), and NHMRC-EU Grant (ID: 1075379). The remaining authors declare no competing interests. EDAT- 2021/05/26 06:00 MHDA- 2021/07/15 06:00 PMCR- 2021/05/24 CRDT- 2021/05/25 06:09 PHST- 2020/10/13 00:00 [received] PHST- 2021/04/30 00:00 [accepted] PHST- 2021/04/12 00:00 [revised] PHST- 2021/05/25 06:09 [entrez] PHST- 2021/05/26 06:00 [pubmed] PHST- 2021/07/15 06:00 [medline] PHST- 2021/05/24 00:00 [pmc-release] AID - 10.1038/s41398-021-01409-4 [pii] AID - 1409 [pii] AID - 10.1038/s41398-021-01409-4 [doi] PST - epublish SO - Transl Psychiatry. 2021 May 24;11(1):312. doi: 10.1038/s41398-021-01409-4.