PMID- 34032016 OWN - NLM STAT- MEDLINE DCOM- 20220228 LR - 20220228 IS - 2053-1095 (Electronic) IS - 2053-1095 (Linking) VI - 7 IP - 5 DP - 2021 Sep TI - Co-infection analysis of bacterial and viral respiratory pathogens from clinically healthy swine in Eastern China. PG - 1815-1819 LID - 10.1002/vms3.533 [doi] AB - Porcine respiratory disease complex (PRDC) is one of the most challenging health concerns for pig production worldwide. The aim of the present study was to determine the prevalence of pathogens associated with PRDC, including porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) and bacterial agents, such as Streptococcus suis, Haemophilus parasuis and Actinobacillus pleuropneumoniae, in clinically healthy pigs in Eastern China. Molecular detection revealed positive single-pathogen detection rates of 59.9%, 27.2%, 52.3%, 33.2% and 0.4% for PCV2, PRRSV, S. suis, H. parasuis and A. pleuropneumoniae, respectively. Co-infection with more than one pathogen was frequently detected in these samples, with PCV2/S. suis, H. parasuis and PCV2/H. parasuis mixed infection rates of 35.4%, 33.2% and 21.6%, respectively, and PCV2/S. suis/H. parasuis and PRRSV/PCV2/S. suis co-infection rates of 21.6% and 6.2%, respectively. These results suggest that mixed infections are prevalent among PRDC cases in swine, which may pose a greater threat to the health of herds compared with single-pathogen infections. CI - (c) 2021 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd. FAU - Zhu, Haodan AU - Zhu H AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. AD - Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China. FAU - Chang, Xinjian AU - Chang X AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. FAU - Zhou, Jinzhu AU - Zhou J AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. FAU - Wang, Dandan AU - Wang D AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. FAU - Zhou, Junming AU - Zhou J AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. FAU - Fan, Baochao AU - Fan B AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. AD - College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, China. FAU - Ni, Yanxiu AU - Ni Y AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. FAU - Yin, Jie AU - Yin J AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. AD - School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China. FAU - Lv, Lixin AU - Lv L AUID- ORCID: 0000-0003-4450-1299 AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. FAU - Zhao, Yongxiang AU - Zhao Y AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. FAU - He, Kongwang AU - He K AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. FAU - Li, Bin AU - Li B AUID- ORCID: 0000-0003-1318-7081 AD - Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China. AD - Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, PR China. AD - Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China. AD - College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, China. LA - eng PT - Case Reports PT - Research Support, Non-U.S. Gov't DEP - 20210525 PL - England TA - Vet Med Sci JT - Veterinary medicine and science JID - 101678837 SB - IM MH - Animals MH - *Circoviridae Infections/epidemiology/veterinary MH - *Circovirus MH - *Coinfection/epidemiology/veterinary MH - *Porcine Reproductive and Respiratory Syndrome/epidemiology MH - Swine MH - *Swine Diseases/microbiology PMC - PMC8464262 OTO - NOTNLM OT - co-infection OT - molecular detection OT - pigs OT - porcine respiratory disease complex OT - respiratory pathogens COIS- No potential con fl ict of interest was reported by the authors. EDAT- 2021/05/26 06:00 MHDA- 2022/03/01 06:00 PMCR- 2021/05/25 CRDT- 2021/05/25 07:01 PHST- 2021/02/24 00:00 [received] PHST- 2021/05/03 00:00 [accepted] PHST- 2021/05/26 06:00 [pubmed] PHST- 2022/03/01 06:00 [medline] PHST- 2021/05/25 07:01 [entrez] PHST- 2021/05/25 00:00 [pmc-release] AID - VMS3533 [pii] AID - 10.1002/vms3.533 [doi] PST - ppublish SO - Vet Med Sci. 2021 Sep;7(5):1815-1819. doi: 10.1002/vms3.533. Epub 2021 May 25.