PMID- 34032704
OWN - NLM
STAT- MEDLINE
DCOM- 20210602
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 21
DP  - 2021 May 28
TI  - Comparison of ultrasound speed-of-sound of the lower extremity and lumbar muscle 
      assessed with computed tomography for muscle loss assessment.
PG  - e25947
LID - 10.1097/MD.0000000000025947 [doi]
LID - e25947
AB  - To compare the speed of propagation of ultrasound (US) waves (SoS) of the lower 
      leg with the clinical reference standard computed tomography (CT) at the level of 
      lumbar vertebra 3 (L3) for muscle loss assessment. Both calf muscles of 50 
      patients scheduled for an abdominal CT were prospectively examined with 
      ultrasound. A plexiglas-reflector located on the opposite side of the probe with 
      the calf in between was used as a timing reference for SoS (m/s). CT measurements 
      were performed at the level of L3 and included area (cm2) and attenuation (HU) of 
      the psoas muscle, abdominal muscles, subcutaneous fat, visceral fat and abdominal 
      area. Correlations between SoS, body mass index (BMI) and CT were determined 
      using Pearson's correlation coefficient. Based on reported CT sarcopenia 
      threshold values, receiver operating characteristic (ROC) analysis was performed 
      for SoS. Inter-examiner agreement was assessed with the median difference, 
      inter-quartile range (IQR) and intraclass correlation coefficients. SoS of the 
      calf correlated moderately with abdominal muscle attenuation (r = 0.48; 
      P < .001), psoas muscle attenuation (r = 0.40; P < .01), abdominal area 
      (r = -0.44; P < .01) and weakly with subcutaneous fat area (r = -0.37; P < .01). 
      BMI correlated weakly with psoas attenuation (r = -0.28; P < .05) and 
      non-significantly with abdominal muscle attenuation. Normalization with abdominal 
      area resulted in moderate correlations with abdominal muscle area for SoS 
      (r = 0.43; P < .01) and BMI (r = -0.46; P < .001). Based on sarcopenia threshold 
      values for skeletal muscle attenuation (SMRA), area under curve (AUC) for SoS was 
      0.724. Median difference between both examiners was -3.4 m/s with IQR = 15.1 m/s 
      and intraclass correlation coefficient = 0.794. SoS measurements of the calf are 
      moderately accurate based on CT sarcopenia threshold values, thus showing 
      potential for muscle loss quantification.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Ruby, Lisa
AU  - Ruby L
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Sanabria, Sergio J
AU  - Sanabria SJ
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland.
AD  - Deusto Institute of Technology, University of Deusto/IKERBASQUE, Basque 
      Foundation for Science, Bilbao, Spain.
FAU - Saltybaeva, Natalia
AU  - Saltybaeva N
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Frauenfelder, Thomas
AU  - Frauenfelder T
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Alkadhi, Hatem
AU  - Alkadhi H
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Rominger, Marga B
AU  - Rominger MB
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland.
LA  - eng
GR  - XXX/USZ Foundation/
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Female
MH  - Humans
MH  - Intra-Abdominal Fat/diagnostic imaging/physiopathology
MH  - Leg/*diagnostic imaging/physiopathology
MH  - Lumbar Vertebrae
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*diagnostic imaging/physiopathology
MH  - Prospective Studies
MH  - ROC Curve
MH  - Reference Values
MH  - Sarcopenia/*diagnosis/physiopathology
MH  - Subcutaneous Fat/diagnostic imaging/physiopathology
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Ultrasonography
PMC - PMC8154376
COIS- The authors have no conflicts of interests to disclose.
EDAT- 2021/05/26 06:00
MHDA- 2021/06/03 06:00
PMCR- 2021/05/28
CRDT- 2021/05/25 13:55
PHST- 2020/10/21 00:00 [received]
PHST- 2021/04/23 00:00 [accepted]
PHST- 2021/05/25 13:55 [entrez]
PHST- 2021/05/26 06:00 [pubmed]
PHST- 2021/06/03 06:00 [medline]
PHST- 2021/05/28 00:00 [pmc-release]
AID - 00005792-202105280-00014 [pii]
AID - MD-D-20-09730 [pii]
AID - 10.1097/MD.0000000000025947 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 May 28;100(21):e25947. doi: 
      10.1097/MD.0000000000025947.