PMID- 34033596
OWN - NLM
STAT- MEDLINE
DCOM- 20220125
LR  - 20230831
IS  - 1528-1159 (Electronic)
IS  - 0362-2436 (Linking)
VI  - 47
IP  - 4
DP  - 2022 Feb 15
TI  - External Validation of the Minimum Clinically Important Difference in the 
      Timed-up-and-go Test After Surgery for Lumbar Degenerative Disc Disease.
PG  - 337-342
LID - 10.1097/BRS.0000000000004128 [doi]
AB  - STUDY DESIGN: Prospective observational cohort study. OBJECTIVE: The aim of this 
      study was to provide external validation of the minimum clinically important 
      difference (MCID) of the Timed-up-and-go (TUG) test. SUMMARY OF BACKGROUND DATA: 
      The TUG test is one of the best explored and most frequently applied objective 
      task-based functional outcome measure in patients with lumbar degenerative disc 
      disease (DDD). The increased use of the TUG test is based on its solid 
      psychometric properties; however, an external validation of the originally 
      determined MCID is lacking. METHODS: Forty-nine patients with lumbar DDD, 
      scheduled for elective spine surgery, were assessed pre- and 6-weeks (W6) 
      postoperative. MCID values were calculate for raw TUG test times (seconds) and 
      standardized TUG z scores using three different computation methods and the 
      following established patient-reported outcome measures (PROMs) as anchors: 
      Visual Analog Scales (VAS), Core Outcome Measures Index Back, Zurich Claudication 
      Questionnaire (ZCQ). RESULTS: The three computation methods generated a range of 
      MCID values, depending on the PROM used as anchor, from 0.9 s (z score of 0.3) 
      based on the VAS leg pain to 3.0 seconds (z score of 2.7) based on the ZCQ 
      physical function scale. The average MCID of the TUG test across all anchors and 
      computation methods was 2.1 s (z score of 1.5). According to the average MCID of 
      raw TUG test values or TUG z scores, 41% and 43% of patients classified as W6 
      responders to surgery, respectively. CONCLUSION: This study confirms the 
      ordinally reported TUG MCID values in patients undergoing surgery for lumbar. A 
      TUG test time change of 2.1 seconds (or TUG z score change of 1.5) indicates an 
      objective and clinically meaningful change in functional status. This report 
      facilitates the interpretation of TUG test results in clinical routine as well as 
      in research.Level of Evidence: 3.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Maldaner, Nicolai
AU  - Maldaner N
AD  - Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience 
      Center, University of Zurich, Zurich, Switzerland.
FAU - Sosnova, Marketa
AU  - Sosnova M
AD  - Department of Neurosurgery, Cantonal Hospital St.Gallen, St.Gallen, Switzerland.
FAU - Ziga, Michal
AU  - Ziga M
AD  - Department of Neurosurgery, Cantonal Hospital St.Gallen, St.Gallen, Switzerland.
FAU - Zeitlberger, Anna M
AU  - Zeitlberger AM
FAU - Bozinov, Oliver
AU  - Bozinov O
AD  - Department of Neurosurgery, Cantonal Hospital St.Gallen, St.Gallen, Switzerland.
FAU - Gautschi, Oliver P
AU  - Gautschi OP
AD  - Neuro- and Spine Center, Hirslanden Clinic St. Anna, Lucerne, Switzerland.
FAU - Weyerbrock, Astrid
AU  - Weyerbrock A
AD  - Department of Neurosurgery, Cantonal Hospital St.Gallen, St.Gallen, Switzerland.
FAU - Regli, Luca
AU  - Regli L
AD  - Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience 
      Center, University of Zurich, Zurich, Switzerland.
FAU - Stienen, Martin N
AU  - Stienen MN
AD  - Department of Neurosurgery, Cantonal Hospital St.Gallen, St.Gallen, Switzerland.
LA  - eng
SI  - ClinicalTrials.gov/NCT03977961
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
SB  - IM
MH  - Disability Evaluation
MH  - Humans
MH  - *Intervertebral Disc Degeneration/diagnosis/surgery
MH  - Lumbar Vertebrae/surgery
MH  - Postural Balance
MH  - Prospective Studies
MH  - Time and Motion Studies
MH  - Treatment Outcome
EDAT- 2021/05/26 06:00
MHDA- 2022/01/27 06:00
CRDT- 2021/05/25 17:15
PHST- 2021/05/26 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/05/25 17:15 [entrez]
AID - 00007632-202202150-00009 [pii]
AID - 10.1097/BRS.0000000000004128 [doi]
PST - ppublish
SO  - Spine (Phila Pa 1976). 2022 Feb 15;47(4):337-342. doi: 
      10.1097/BRS.0000000000004128.