PMID- 34034059
OWN - NLM
STAT- MEDLINE
DCOM- 20210924
LR  - 20240226
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 266
DP  - 2021 Oct
TI  - Mesenteric Lymph Drainage Improves Cardiac Papillary Contractility and Calcium 
      Sensitivity in Rats with Hemorrhagic Shock.
PG  - 245-253
LID - S0022-4804(21)00238-9 [pii]
LID - 10.1016/j.jss.2021.04.008 [doi]
AB  - BACKGROUND: Myocardial dysfunction is an important adverse factor of hemorrhagic 
      shock that induces refractory hypotension, and post-hemorrhagic shock mesenteric 
      lymph (PHSML) return is involved in this adverse effect. This study investigated 
      whether mesenteric lymph drainage (MLD) improves PHSML return-induced cardiac 
      contractile dysfunction via the restoration of cardiomyocyte calcium sensitivity. 
      MATERIALS AND METHODS: A hemorrhage shock model was established by using a 
      controlled hemorrhage through the femoral artery that maintained a mean arterial 
      pressure of 40 +/- 2 mmHg for 3 h. MLD and mesenteric lymph duct ligation (MLDL) 
      were performed from 1 to 3 h during hypotension. The papillary muscles of the 
      heart were collected for measurement of calmodulin expression and for determining 
      contractile responses to either isoprenaline or calcium. RESULTS: The results 
      showed that either MLD or MLDL reversed the hemorrhagic shock-induced 
      downregulation of calmodulin expression, a marker protein of cardiomyocyte 
      calcium sensitization, in papillary muscles. MLD also improved the decreased 
      contractile response and +/-df/dt of the papillary muscle strip to 
      gradient isoprenaline or calcium caused by hemorrhagic shock. CONCLUSION: These 
      findings indicate that increased cardiac contractibility may be associated with 
      the restoration of calcium sensitivity produced by PHSML drainage.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Wang, Xiao-Rong
AU  - Wang XR
AD  - Institute of Microcirculation, Hebei North University, Zhangjiakou, China; Hebei 
      Key Laboratory of Critical Disease Mechanism and Intervention, Hebei Medical 
      University & Hebei North University, Shijiazhuang & Zhangjiakou, China.
FAU - Du, Hui-Bo
AU  - Du HB
AD  - Institute of Microcirculation, Hebei North University, Zhangjiakou, China; Hebei 
      Key Laboratory of Critical Disease Mechanism and Intervention, Hebei Medical 
      University & Hebei North University, Shijiazhuang & Zhangjiakou, China.
FAU - Wang, Huai-Huai
AU  - Wang HH
AD  - Institute of Microcirculation, Hebei North University, Zhangjiakou, China; The 
      Second Affiliated Hospital, Hebei North University, Zhangjiakou, China.
FAU - Zhang, Li-Min
AU  - Zhang LM
AD  - Institute of Microcirculation, Hebei North University, Zhangjiakou, China; Hebei 
      Key Laboratory of Critical Disease Mechanism and Intervention, Hebei Medical 
      University & Hebei North University, Shijiazhuang & Zhangjiakou, China.
FAU - Si, Yong-Hua
AU  - Si YH
AD  - Department of Pediatrics, Cangzhou City People's Hospital, Cangzhou, China.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Institute of Microcirculation, Hebei North University, Zhangjiakou, China.
FAU - Zhao, Zi-Gang
AU  - Zhao ZG
AD  - Institute of Microcirculation, Hebei North University, Zhangjiakou, China; Hebei 
      Key Laboratory of Critical Disease Mechanism and Intervention, Hebei Medical 
      University & Hebei North University, Shijiazhuang & Zhangjiakou, China. 
      Electronic address: zzghyl@126.com.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210523
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Calmodulin)
SB  - IM
MH  - Animals
MH  - Calmodulin/*metabolism
MH  - Cardiomyopathies/etiology/*prevention & control
MH  - Lymphatic Vessels/*surgery
MH  - Male
MH  - Papillary Muscles/*physiology
MH  - Rats, Wistar
MH  - Shock, Hemorrhagic/*complications/metabolism
MH  - Rats
OTO - NOTNLM
OT  - Calcium sensitivity
OT  - Contraction
OT  - Hemorrhagic shock
OT  - Mesenteric lymph
OT  - Papillary muscle
EDAT- 2021/05/26 06:00
MHDA- 2021/09/25 06:00
CRDT- 2021/05/25 20:19
PHST- 2020/12/15 00:00 [received]
PHST- 2021/03/29 00:00 [revised]
PHST- 2021/04/01 00:00 [accepted]
PHST- 2021/05/26 06:00 [pubmed]
PHST- 2021/09/25 06:00 [medline]
PHST- 2021/05/25 20:19 [entrez]
AID - S0022-4804(21)00238-9 [pii]
AID - 10.1016/j.jss.2021.04.008 [doi]
PST - ppublish
SO  - J Surg Res. 2021 Oct;266:245-253. doi: 10.1016/j.jss.2021.04.008. Epub 2021 May 
      23.