PMID- 34036796
OWN - NLM
STAT- MEDLINE
DCOM- 20211231
LR  - 20211231
IS  - 1557-900X (Electronic)
IS  - 0892-7790 (Linking)
VI  - 35
IP  - 12
DP  - 2021 Dec
TI  - Minipercutaneous Nephrolithotomy Under Mixture of Local Anesthesia: A Randomized 
      Controlled Study.
PG  - 1750-1756
LID - 10.1089/end.2021.0234 [doi]
AB  - Objective: To evaluate the safety, efficacy, and feasibility of minipercutaneous 
      nephrolithotomy (MPCNL) under mixture of local anesthetics (MLA) vs spinal 
      anesthesia (SA) for management of large renal stones. Patients and Methods: This 
      study was a prospective randomized controlled study and approved by IRB 
      (REC-FOMBU). A total of 120 consecutive patients who met the inclusion criteria 
      of the study and agreed to sign the informed consent form were randomized to 
      undergo MPCNL under MLA (60 patients) or SA (60 patients). Intra- and 
      postoperative findings including visual pain analogue scale (VAS), operative 
      time, hospital stay, adverse events (AEs), stone-free rate, and related data were 
      recorded. Results: Baseline characteristics and demography included age and 
      gender; stone's site, size, and density were comparable for both groups 
      (p > 0.05). The average VAS scores in the MLA group at 0, 2, 6, 12, and 24 hours 
      were 2.5, 0, 1, 1, and 0, respectively. The corresponding values in the SA group 
      were 2, 1, 2, 2, and 1, respectively, (p < 0.05). The average operation time was 
       approximately 1 hour for both groups and the length of hospital stay was 1.5 days for both 
      groups (p > 0.05). Whereas the mean hemoglobin deficit was 1.04% +/- 0.54% vs 
      1.27 +/- 0.46 (p = 0.013) and the primary postoperative stone clearance was 93.4% 
      vs 88.3% (p > 0.05), for MLA and SA groups, respectively. Postoperative analgesic 
      consumption and complications were similar in the MLA and SA groups. Conclusion: 
      Single tract MPCNL is feasible under either MLA or SA with comparable stone 
      clearance and AEs. Perioperative VAS was similar and acceptable for both 
      modalities.
FAU - El-Shaer, Waleed
AU  - El-Shaer W
AD  - Department of Urology, Banha University Hospital, Banha, Egypt.
FAU - Shaboob, Eslam
AU  - Shaboob E
AD  - Department of Anesthesiology, and Banha University Hospital, Banha, Egypt.
FAU - Abdel-Lateef, Sally
AU  - Abdel-Lateef S
AD  - Department of Radiology, Banha University Hospital, Banha, Egypt.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20211026
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
SB  - IM
MH  - Anesthesia, Local
MH  - Humans
MH  - *Kidney Calculi/surgery
MH  - *Nephrolithotomy, Percutaneous/adverse effects
MH  - Prospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - MPCNL
OT  - SFR
OT  - VAS
OT  - local anesthesia
OT  - spinal anesthesia
EDAT- 2021/05/27 06:00
MHDA- 2022/01/01 06:00
CRDT- 2021/05/26 08:42
PHST- 2021/05/27 06:00 [pubmed]
PHST- 2022/01/01 06:00 [medline]
PHST- 2021/05/26 08:42 [entrez]
AID - 10.1089/end.2021.0234 [doi]
PST - ppublish
SO  - J Endourol. 2021 Dec;35(12):1750-1756. doi: 10.1089/end.2021.0234. Epub 2021 Oct 
      26.