PMID- 34039466
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 78
IP  - 4
DP  - 2021 Oct
TI  - Saphenous vein size as a surrogate marker for mortality of patients with chronic 
      limb-threatening ischemia undergoing endovascular therapy.
PG  - 341-346
LID - S0914-5087(21)00109-X [pii]
LID - 10.1016/j.jjcc.2021.04.012 [doi]
AB  - BACKGROUND: The size of the autologous vein graft is an important determinant of 
      prognosis in patients with chronic limb-threatening ischemia (CLTI) undergoing 
      bypass surgery. However, it is unclear whether reconstruction using a small vein 
      graft would directly affect prognosis, or a subgroup having small veins would be 
      subject to a poor prognosis. If the latter is true, having small veins would work 
      as a marker for a poor prognosis even in patients with CLTI undergoing 
      endovascular therapy (EVT). Therefore, we investigated the association between 
      the size of saphenous veins and prognosis in patients with CLTI undergoing EVT. 
      METHODS: This study included 209 consecutive patients with CLTI who primarily 
      underwent EVT between January 2017 and December 2018. The diameter of the 
      saphenous vein was measured at three locations (saphenous-femoral junction, knee, 
      and ankle joint) per limb before EVT by ultrasonography. A small saphenous vein 
      was defined as the mean diameter <3.0 mm. RESULTS: All-cause mortality rate was 
      significantly higher in patients with a small saphenous vein than in those with 
      non-small one (46.3% versus 10.7% at 2 years, p<0.001). The multivariate Cox 
      regression analysis revealed that a small saphenous vein was independently 
      associated with an increased risk of all-cause mortality. CONCLUSIONS: Having a 
      small saphenous vein was an independent marker for all-cause mortality in 
      patients with CLTI undergoing EVT.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Hata, Yosuke
AU  - Hata Y
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan. Electronic address: hata.yosuke@gmail.com.
FAU - Iida, Osamu
AU  - Iida O
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
FAU - Takahara, Mitsuyoshi
AU  - Takahara M
AD  - Department of Diabetes Care Medicine, Osaka University Graduate School of 
      Medicine, Osaka, Japan.
FAU - Asai, Mitsutoshi
AU  - Asai M
AD  - Department of Diabetes Care Medicine, Osaka University Graduate School of 
      Medicine, Osaka, Japan.
FAU - Masuda, Masaharu
AU  - Masuda M
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
FAU - Okamoto, Shin
AU  - Okamoto S
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
FAU - Ishihara, Takayuki
AU  - Ishihara T
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
FAU - Nanto, Kiyonori
AU  - Nanto K
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
FAU - Kanda, Takashi
AU  - Kanda T
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
FAU - Tsujumura, Takuya
AU  - Tsujumura T
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
FAU - Matsuda, Yasuhiro
AU  - Matsuda Y
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
FAU - Yanaka, Koji
AU  - Yanaka K
AD  - Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, 
      Nishinomiya, Japan.
FAU - Mano, Toshiaki
AU  - Mano T
AD  - Kansai Rosai Hospital Cardiovascular Center, Inabaso, 3-1-69 Inabaso, Amagasaki, 
      Hyogo 660-8511, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210524
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - *Endovascular Procedures
MH  - Humans
MH  - Ischemia/diagnostic imaging
MH  - Limb Salvage
MH  - *Peripheral Arterial Disease/surgery
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Saphenous Vein/diagnostic imaging
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vascular Patency
OTO - NOTNLM
OT  - All-cause mortality
OT  - Chronic limb-threatening ischemia
OT  - Endovascular therapy
OT  - Saphenous vein
OT  - Surrogate marker
EDAT- 2021/05/28 06:00
MHDA- 2021/11/25 06:00
CRDT- 2021/05/27 05:43
PHST- 2021/02/26 00:00 [received]
PHST- 2021/04/16 00:00 [revised]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2021/05/28 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/05/27 05:43 [entrez]
AID - S0914-5087(21)00109-X [pii]
AID - 10.1016/j.jjcc.2021.04.012 [doi]
PST - ppublish
SO  - J Cardiol. 2021 Oct;78(4):341-346. doi: 10.1016/j.jjcc.2021.04.012. Epub 2021 May 
      24.