PMID- 34039832
OWN - NLM
STAT- MEDLINE
DCOM- 20220603
LR  - 20221207
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Print)
IS  - 1340-3478 (Linking)
VI  - 29
IP  - 6
DP  - 2022 Jun 1
TI  - Ambulatory Status Over Time after Revascularization in Patients with Chronic 
      Limb-Threatening Ischemia.
PG  - 866-880
LID - 10.5551/jat.62892 [doi]
AB  - AIM: Maintaining functional status through revascularization is a major goal in 
      patients with chronic limb-threatening ischemia (CLTI). Nevertheless, there is a 
      lack of clarity on the impact of revascularization on mobility over time. This 
      study examined ambulatory status over time after revascularization and predictors 
      of ambulation loss in CLTI patients. METHODS: We used a clinical database 
      established by the Surgical reconstruction versus Peripheral INtervention in 
      pAtients with critical limb isCHemia study, a prospective, multicentre, 
      observational study including patients with CLTI. The primary endpoint was 
      mobility over time. RESULTS: Of the 381 patients, the ambulatory proportion at 
      baseline was 71%. The proportion gradually decreased, finally reaching 40% at 36 
      months. In non-ambulatory patients at revasacularisation, approximately 20-40% of 
      patients achieved ambulation. Multivariate analysis confirmed that age, impaired 
      mobility before CLTI onset and at revascularization, renal failure on dialysis, 
      and WIfI clinical stage 4 were positively associated with ambulation loss at 
      either specific or all time points, whereas male sex and surgical reconstruction 
      were inversely associated with the outcomes at specific time points. CONCLUSION: 
      Mobility in the overall population gradually decreased, whereas the number of 
      deceased patients increased. Advanced age, impaired mobility before CLTI onset 
      and at revascularization, renal failure on dialysis, and WIfI stage 4 were 
      associated with ambulation loss at almost all points after revascularization.
FAU - Kodama, Akio
AU  - Kodama A
AD  - Division of Vascular Surgery, Department of Surgery, Nagoya University School of 
      Medicine.
FAU - Takahara, Mitsuyoshi
AU  - Takahara M
AD  - Department of Diabetes Care Medicine, and Department of Metabolic Medicine, Osaka 
      University Graduate School of Medicine.
FAU - Iida, Osamu
AU  - Iida O
AD  - Cardiovascular Center, Kansai Rosai Hospital.
FAU - Soga, Yoshimitsu
AU  - Soga Y
AD  - Department of Cardiology, Kokura Memorial Hospital.
FAU - Terashi, Hiroto
AU  - Terashi H
AD  - Department of Plastic Surgery, Kobe University Graduate School of Medicine.
FAU - Kawasaki, Daizo
AU  - Kawasaki D
AD  - Cardiovascular Center, Morinomiya Hospital.
FAU - Izumi, Yuichi
AU  - Izumi Y
AD  - Nayoro City General Hospital.
FAU - Mii, Shinsuke
AU  - Mii S
AD  - Department of Vascular Surgery, Saiseikai Yahata General Hospital.
FAU - Komori, Kimihiro
AU  - Komori K
AD  - Division of Vascular Surgery, Department of Surgery, Nagoya University School of 
      Medicine.
FAU - Azuma, Nobuyoshi
AU  - Azuma N
AD  - Department of Vascular Surgery, Asahikawa Medical University.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210527
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
SB  - IM
MH  - Amputation, Surgical
MH  - Chronic Limb-Threatening Ischemia
MH  - *Endovascular Procedures
MH  - Humans
MH  - Ischemia/surgery
MH  - Limb Salvage
MH  - Male
MH  - *Peripheral Arterial Disease/complications/surgery
MH  - Prospective Studies
MH  - *Renal Insufficiency/surgery
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC9174083
OTO - NOTNLM
OT  - Ambulatory
OT  - Ambulatory status
OT  - Chronic limb-threatening ischemia
OT  - Functional status
OT  - Revascularization
EDAT- 2021/05/28 06:00
MHDA- 2022/06/07 06:00
PMCR- 2022/06/01
CRDT- 2021/05/27 05:53
PHST- 2021/05/28 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2021/05/27 05:53 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - DN/JST.JSTAGE/jat/62892 [pii]
AID - 10.5551/jat.62892 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2022 Jun 1;29(6):866-880. doi: 10.5551/jat.62892. Epub 2021 
      May 27.