PMID- 34040473
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 1179-2736 (Print)
IS  - 1179-2736 (Electronic)
IS  - 1179-2736 (Linking)
VI  - 12
DP  - 2021
TI  - Heterogeneity in Hematological Parameters of High and Low Altitude Tibetan 
      Populations.
PG  - 287-298
LID - 10.2147/JBM.S294564 [doi]
AB  - INTRODUCTION: High altitude hypoxia is believed to be experienced at elevations 
      of more than 2500 meters above sea level. Several studies have shed light on the 
      biochemical aspects of high altitude acclimatization, where participants were 
      sojourners to the high altitude from low altitude areas. However, information 
      regarding the difference between the high altitude adapted Tibetans living at 
      high altitude and their counterparts who reside at low altitude are lacking. To 
      understand this, we have measured various hematological parameters in the Tibetan 
      populations, who are residing in both high and low altitudes in India. METHODS: A 
      total of 168 individuals (79 from high altitude (>/=4500 meters) and 89 from low 
      altitude (~850 meters) were recruited for this study. Hematological parameters 
      such as red blood cells (RBC) count, hematocrit (HCT), hemoglobin concentration 
      (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean 
      corpuscular hemoglobin concentration (MCHC) were measured from the individuals 
      from high and low altitudes. Serum erythropoietin (EPO) was measured by ELISA. 
      Statistical analyses were performed to compare data from both of the altitudes. 
      Gender-wise comparison of data was reported. Correlation analysis was performed 
      within relevant parameters. RESULTS: Highly significant differences (p <0.0001) 
      between high and low altitude Tibetans were detected in RBC count, HCT, Hb, MCHC 
      in both males and females and in MCV in females. In the case of MCHC, however, 
      age and BMI were potential confounders. Nominally significant differences (p 
      <0.05) were detected in MCV and MCH within males. No significant difference in 
      serum EPO level was found between altitude groups, in any gender. No significant 
      correlation was found between serum EPO with Hb as well as serum EPO with HCT. 
      DISCUSSION: Our study explores significantly lower RBC count, HCT, Hb, MCH, MCHC 
      and higher MCV in long-term Tibetan residents living at low altitude compared to 
      their high altitude counterparts, which is likely due to the outcome of 
      hematological adaptation to a relatively hyperoxic environment in low altitude 
      areas.
CI  - (c) 2021 Basak et al.
FAU - Basak, Nipa
AU  - Basak N
AUID- ORCID: 0000-0001-8728-5202
AD  - CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
AD  - Academy of Scientific and Innovative Research, Ghaziabad, India.
FAU - Norboo, Tsering
AU  - Norboo T
AD  - Ladakh Institute of Prevention, Leh, India.
FAU - Mustak, Mohammed S
AU  - Mustak MS
AUID- ORCID: 0000-0001-7572-7229
AD  - Mangalore University, Mangalore, India.
FAU - Thangaraj, Kumarasamy
AU  - Thangaraj K
AUID- ORCID: 0000-0002-0075-0106
AD  - CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
AD  - Academy of Scientific and Innovative Research, Ghaziabad, India.
AD  - DBT-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
LA  - eng
PT  - Journal Article
DEP - 20210517
PL  - New Zealand
TA  - J Blood Med
JT  - Journal of blood medicine
JID - 101550884
PMC - PMC8139737
OTO - NOTNLM
OT  - Tibetans
OT  - erythropoietin
OT  - hematological parameters
OT  - high altitude
OT  - low altitude
COIS- The authors declared no conflicts of interest for this work.
EDAT- 2021/05/28 06:00
MHDA- 2021/05/28 06:01
PMCR- 2021/05/17
CRDT- 2021/05/27 06:38
PHST- 2020/12/02 00:00 [received]
PHST- 2021/03/16 00:00 [accepted]
PHST- 2021/05/27 06:38 [entrez]
PHST- 2021/05/28 06:00 [pubmed]
PHST- 2021/05/28 06:01 [medline]
PHST- 2021/05/17 00:00 [pmc-release]
AID - 294564 [pii]
AID - 10.2147/JBM.S294564 [doi]
PST - epublish
SO  - J Blood Med. 2021 May 17;12:287-298. doi: 10.2147/JBM.S294564. eCollection 2021.