PMID- 34041284
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210528
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in 
      Community-Dwelling Elderly Chinese: The North Shanghai Study.
PG  - 662741
LID - 10.3389/fcvm.2021.662741 [doi]
LID - 662741
AB  - Introduction: Serum homocysteine (Hcy) level is associated with 
      cardiocerebrovascular disease. However, the relationship between Hcy and 
      hypertension-mediated organ damage (HMOD) in non-hospitalized residents has not 
      been elucidated. We aimed to investigate the association of HMOD with Hcy in 
      elderly Chinese. Methods: One thousand seven hundred and forty-four 
      community-dwelling elderly Chinese (age >/=65 years) participated in the Northern 
      Shanghai Study from Jun. 2014 to Aug. 2015. Hyperhomocysteinemia (HHcy) was 
      defined as serum Hcy >/=15 mmol/L, and HMOD was estimated as arterial stiffness 
      [carotid-femoral pulse wave velocity (CF-PWV) and ankle-brachial index (ABI)], 
      cardiac impairment [left ventricular (LV) hypertrophy and LV diastolic 
      dysfunction], and renal dysfunction [estimated glomerular filtration rate (eGFR) 
      and urinary albumin/creatinine ratio]. Linear and logistic regression models were 
      built to explore the associations of HMOD with Hcy. Results: Among 1,744 
      participants, 632 (36.2%) were diagnosed as HHcy. HHcy group had more men (61.2 
      vs. 35.3%), with higher age (73.7 +/- 6.7 vs. 70.4 +/- 5.3 years) and BMI (24.2 +/- 3.4 
      vs. 23.7 +/- 3.5 kg/m(2)). Linear regression analysis showed that serum Hcy level 
      was positively associated CF-PWV and negatively associated with ABI and eGFR. By 
      logistic regression, HHcy was significantly associated with abnormal CF-PWV [odds 
      ratio (OR) = 1.53, 95% confidence interval (CI) 1.08-2.16] and ABI (OR = 1.55, 
      95% CI 1.17-2.04), and decreased eGFR (OR = 7.09, 95% CI 4.03-12.47) after 
      adjustment for covariates. Moreover, similar associations of serum Hcy level with 
      CF-PWV and eGFR were observed in subgroups by gender and hypertensive state. 
      Conclusion: HMOD, particularly renal dysfunction and arterial stiffening, was 
      significantly and independently associated with increased serum Hcy level in the 
      elderly Chinese. Clinical Trial Registration: [ClinicalTrial.gov], identifier 
      [NCT02368938].
CI  - Copyright (c) 2021 Ren, Zhang, Yu, Zhao, Tang, Zheng, Meng, Xu, Zhang and Xu.
FAU - Ren, Zhongyuan
AU  - Ren Z
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
AD  - Soochow University Medical College, Suzhou Industrial Park (SIP), Suzhou, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Yu, Shikai
AU  - Yu S
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Zhao, Song
AU  - Zhao S
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Tang, Jiamin
AU  - Tang J
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Zheng, Yixing
AU  - Zheng Y
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Meng, Weilun
AU  - Meng W
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Xu, Chong
AU  - Xu C
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Xu, Yawei
AU  - Xu Y
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT02368938
PT  - Case Reports
DEP - 20210510
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8141577
OTO - NOTNLM
OT  - Chinese
OT  - elderly
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - hypertension-mediated organ damage
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/05/28 06:00
MHDA- 2021/05/28 06:01
PMCR- 2021/01/01
CRDT- 2021/05/27 06:50
PHST- 2021/02/04 00:00 [received]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/05/27 06:50 [entrez]
PHST- 2021/05/28 06:00 [pubmed]
PHST- 2021/05/28 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.662741 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 May 10;8:662741. doi: 10.3389/fcvm.2021.662741. 
      eCollection 2021.